Fabrication of thromboresistant multilayer thin film on plasma treated poly (vinyl chloride) surface

Tan, Qinggang; Ji, Jian; Zhao, Feng; Fan, Di; Sun, Fu-Yu; Shen, Jiacong

doi:10.1007/s10856-005-2541-5

Cited by 27 publications

(20 citation statements)

References 21 publications

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“…In fact, LbL deposition generates films with alternating surface properties (e.g. contact angle [74,75] and ζ potential [76]). So the intrinsic properties of terminating polyelectrolytes such as their charged states as well as their hydrophilicity are viable tools to control the final surface properties of the multilayer film.…”

Section: Methods Of Controlling Lbl Assemblymentioning

confidence: 99%

“…However, the synthetic polycation PEI possesses high cytotoxicity [147]. Therefore, hemocompatible albumin/HEP films have been introduced by Tan et al as biomaterial coatings and were found to be anti-coagulant and to reduce platelet adhesion drastically [74]. These albumin/HEP system was also tested for its ability to potentiate thrombin inhibition by anti-thrombin [148].…”

Section: Surface Negative Charge Introductionmentioning

confidence: 99%

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Controlling cell adhesion using layer-by-layer approaches for biomedical applications

Guo

Zhu

Loh

2017

Materials Science and Engineering: C

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Section: Methods Of Controlling Lbl Assemblymentioning

confidence: 99%

Section: Surface Negative Charge Introductionmentioning

confidence: 99%

Controlling cell adhesion using layer-by-layer approaches for biomedical applications

Guo

Zhu

Loh

2017

Materials Science and Engineering: C

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“…[201] The coated PEM greatly prolonged the plasma recalcification time. The films were also tested for their ability to potentiate thrombin inhibition by anti-thrombin and its dependence on the layer arrangement.…”

Section: Anti-coagulationmentioning

confidence: 99%

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

Boudou¹,

Crouzier²,

Ren³

et al. 2010

Advanced Materials

686

702

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The design of advanced functional materials with nanometer- and micrometer-scale control over their properties is of considerable interest for both fundamental and applied studies because of the many potential applications for these materials in the fields of biomedical materials, tissue engineering, and regenerative medicine. The layer-by-layer deposition technique introduced in the early 1990s by Decher, Moehwald, and Lvov is a versatile technique, which has attracted an increasing number of researchers in recent years due to its wide range of advantages for biomedical applications: ease of preparation under "mild" conditions compatible with physiological media, capability of incorporating bioactive molecules, extra-cellular matrix components and biopolymers in the films, tunable mechanical properties, and spatio-temporal control over film organization. The last few years have seen a significant increase in reports exploring the possibilities offered by diffusing molecules into films to control their internal structures or design "reservoirs," as well as control their mechanical properties. Such properties, associated with the chemical properties of films, are particularly important for designing biomedical devices that contain bioactive molecules. In this review, we highlight recent work on designing and controlling film properties at the nanometer and micrometer scales with a view to developing new biomaterial coatings, tissue engineered constructs that could mimic in vivo cellular microenvironments, and stem cell "niches."

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“…This has been achieved through a variety of techniques including covalent linking via a spacer [5][6][7][8], layer-by-layer deposition [9][10][11], photochemical coupling [12], physical adsorption [13], or in the form of block copolymers [14,15]. Conversely, it has been reported that heparin can be released from polymers through both ion-exchange mechanisms and via diffusion [16].…”

Section: Introductionmentioning

confidence: 99%

Polyurethane Organosilicate Nanocomposites as Blood Compatible Coatings

et al. 2012

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Polymer clay nanocomposites (NCs) show remarkable potential in the field of drug delivery due to their enhanced barrier properties. It is hypothesised that well dispersed clay particles within the polymer matrix create a tortuous pathway for diffusing therapeutic molecules, thereby resulting in more sustained release of the drug. As coatings for medical devices, these materials can simultaneously modulate drug release and improve the mechanical performance of an existing polymer system without introducing additional materials with new chemistries that can lead to regulatory concerns. In this study, polyurethane organosilicate nanocomposites (PUNCs) coated onto stainless steel wires were evaluated for their feasibility as blood compatible coatings and as drug delivery systems. Heparin was selected as the model drug to examine the impact of silicate loading and modifier chain length in modulating release. Findings revealed that better dispersion was achieved from samples with lower clay loadings and longer alkyl chains. The blood compatibility of PUNCs as assessed by thrombin generation assays showed that the addition of silicate particles did not significantly decrease the thrombin generation lag time (TGT, p = 0.659) or the peak thrombin (p = 0.999) of polyurethane (PU). PUNC coatings fabricated in this research were not cytotoxic as examined by the cell growth inhibition OPEN ACCESSCoatings 2012, 2 46 assay and were uniformly intact, but had slightly higher growth inhibition compared to PU possibly due to the presence of organic modifiers (OM). The addition of heparin into PUNCs prolonged the TGT, indicating that heparin was still active after the coating process. Cumulative heparin release profiles showed that the majority of heparin released was from loosely attached residues on the surface of coils. The addition of heparin further prolonged the TGT as compared to coatings without added heparin, but a slight decrease in heparin activity was observed in the NCs. This was thought to be from competitive interactions between clay-heparin that influenced the formation of the ternary complex between heparin, ATIII thrombin. In summary, the feasibility of using PUNC as drug delivery coatings was shown by the good uniformity in the coating, absence of by-products from the coating process, and the release of active molecules without significantly interfering with their activity.

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Fabrication of thromboresistant multilayer thin film on plasma treated poly (vinyl chloride) surface

Cited by 27 publications

References 21 publications

Controlling cell adhesion using layer-by-layer approaches for biomedical applications

Controlling cell adhesion using layer-by-layer approaches for biomedical applications

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

Polyurethane Organosilicate Nanocomposites as Blood Compatible Coatings

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