Fabrication of three dimensional printed tablets in flexible doses: A comprehensive study from design to evaluation

Gültekin, Hazal Ezgi; Tort, Serdar; Acartürk, Füsun

doi:10.1016/j.jddst.2022.103538

Cited by 4 publications

(4 citation statements)

References 50 publications

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“…There are also reports on the increase in drug dissolution rates by the incorporation of polyethylene oxide as the additive [ 38 , 43 , 51 , 52 ]. For example, Gultekin et al [ 38 ] used mixtures of Eudragit® EPO and polyethylene oxide (PEO) N80 at 70:30, 60:40 and 50:50 w/w ratios for a low-dose drug (0.25 to 1 mg) and observed complete drug release in a pH 1.2 medium (0.1M HCl) in 20 min.…”

Section: Current Strategies For the Development Of Rapid-release Fdm ...mentioning

confidence: 99%

Challenges, current status and emerging strategies in the development of rapidly dissolving FDM 3D-printed tablets: An overview and commentary

Serajuddin

2023

ADMET DMPK

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Since the approval of a 3D-printed tablet by the FDA in 2015 for marketing, there has been a great interest in 3D printing in the pharmaceutical field for the development of personalized and on-demand medications. Among various 3D printing methods explored for the development of oral solid dosage form like tablet, the fused deposition modeling (FDM) 3D-printing, where the drug-polymer mixtures are first converted into filaments by hot melt extrusion (HME) and then the filaments are printed into tablets using 3D printers by applying computer-aided design principles, has emerged as the most attractive option. However, no FDM 3D-printed tablets have yet been marketed as the technology faces many challenges, such as limited availability of pharmaceutical-grade polymers that can be printed into tablets, low drug-polymer miscibility, the need for high temperature for HME and 3D-printing, and slow drug release rates from tablets. These challenges are discussed in this article with a special focus on drug release rates since FDM 3D-printing usually leads to the preparation of slow-release tablets while the rapid release from dosage forms is often desired for optimal therapeutic outcomes of new drug candidates. Pros and cons of various strategies for the development of rapidly dissolving FDM 3D-printed tablets reported in the literature are reviewed. Finally, two case studies on emerging strategies for the development of rapidly dissolving FDM 3D-printed tablets are presented, where one outlines a systematic approach for formulating rapidly dissolving tablets, and the other describes a novel strategy to increase dissolution rates of drugs from FDM 3D-printed tablets, which at the same time can also increase drug-polymer miscibility and printability of tablets and lower processing temperatures. Thus, this overview and commentary discusses various issues involving the formulation of rapidly dissolving FDM 3D-printed tablets and provides guidance for the development of commercially viable products.

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Section: Current Strategies For the Development Of Rapid-release Fdm ...mentioning

confidence: 99%

Challenges, current status and emerging strategies in the development of rapidly dissolving FDM 3D-printed tablets: An overview and commentary

Serajuddin

2023

ADMET DMPK

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“…Reproduced with permission from John Wiley and Sons, Copyright © 2020, John Wiley and Sons. (D) 3D printing-based personalized drug customization strategies [ 82 ] . Reproduced with permission from Elsevier, Copyright ©2022, Elsevier.…”

Section: Applications Of 3d Printing In Medical Conditions Associated...mentioning

confidence: 99%

“…However, only a limited selection of standard doses is available in the market. Gultekin et al [ 82 ] used fused deposition modeling (FDM) 3D printing to create dosage forms for pramipexole with varied release characteristics. The results showed that 3D-printed tablets could be successfully manufactured into personalized doses and that the desired drug release profile is achievable by adjusting the formulation ( Figure 2D ).…”

Section: Applications Of 3d Printing In Medical Conditions Associated...mentioning

confidence: 99%

Applications of 3D printing in aging

Ma¹,

J²,

Wang³

et al. 2023

ijb

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Aging is inevitable, and how to age healthily is a key concern. Additive manufacturing offers many solutions to this problem. In this paper, we first briefly introduce various 3D printing technologies commonly used in the biomedical field, particularly in aging research and aging care. Next, we closely examine aging-related health conditions of nervous system, musculoskeletal system, cardiovascular system, and digestive system with a focus on the application of 3D printing in these fields, including the creation of in vitro models and implants, production of drugs and drug delivery systems, and fabrication of rehabilitation and assistive medical devices. Finally, the opportunities, challenges, and prospects of 3D printing in the field of aging are discussed.

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“…As a result, the formed solid dosage form, which showed a polymer common structure, becomes hard and rigid. However, immediate release can be extended to dosage forms made by FDM62 3D printing, including the preparation of 3D dosage forms using instant polymers, the construction of special designs such as tablets containing 64 gaps, and the addition of other excipients such as decomposers to Medicinal formulations, especially for commercially uses [20,21].…”

Section: Immediate-releasementioning

confidence: 99%

3D printing of bioactive materials for drug delivery applications

Nasiri

Ahmadi

Shahbazi

et al. 2022

Expert Opinion on Drug Delivery

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Introduction: Three-dimensional (3D) printing, also known as additive manufacturing (AM), is a modern technique/technology, which makes it possible to construct 3D objects from computer-aided design (CAD) digital models. This technology can be used in the progress of drug delivery systems, where porosity has played important role in attaining an acceptable level of biocompatibility and biodegradability with improved therapeutic effects. 3D printing may also provide the user possibility to control the dosage of each ingredient in order to a specific purpose, and makes it probable to improve the formulation of drug delivery systems. Areas covered: This article covers the 3D printing technologies, bioactive materials including natural and synthetic polymers as well as some ceramics and minerals and their roles in drug delivery systems. Expert opinion: This technology is feasible to fabricate drug products by incorporating multiple drugs in different parts in such a mode that these drugs can release from the section at a predetermined rate. Furthermore, this 3D printing technology has the potential to transform personalized therapy to various age-groups by design flexibility and precise dosing. In recent years, the potential use of this technology can be realized in a clinical situation where patients will acquire individualized medicine as per their requirement.

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Fabrication of three dimensional printed tablets in flexible doses: A comprehensive study from design to evaluation

Cited by 4 publications

References 50 publications

Challenges, current status and emerging strategies in the development of rapidly dissolving FDM 3D-printed tablets: An overview and commentary

Challenges, current status and emerging strategies in the development of rapidly dissolving FDM 3D-printed tablets: An overview and commentary

Applications of 3D printing in aging

3D printing of bioactive materials for drug delivery applications

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