Fabrication of sustained-release zein nanoparticles via modified coaxial electrospraying

Liu, Zhepeng; Zhang, Yao‐Yao; Yu, Deng‐Guang; Wu, Di; Li, Haolin

doi:10.1016/j.cej.2017.10.098

Cited by 93 publications

(49 citation statements)

References 67 publications

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“…For instance, Liu et al. () elaborated nanoparticles by coaxial electrospray using 12% zein and 3% (w/v) tamoxifen citrate and concluded that this technique produces particles with better quality in terms of particle size, distribution of size, and morphology. Other studies have developed zein nanoparticles by the electrospraying technique (Baspinar, Üstündas, Bayraktar, & Sezgin, ; Bhushani, Kurrey, & Anandharamakrishnan, ; Gómez‐Estaca, Balaguer, Gavara, & Hernandez‐Munoz, ; Tapia‐Hernández et al., ), and coincide that at 5% zein, nanoparticles are obtained with a spherical, monodispersed, compact structure, with size ranging between 157 and 500 nm, and encapsulation efficiency ranging from 80% up to 97.44% for curcumin and catechins.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Rodríguez-Félix

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

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Quercetin is a hydrophobic flavonoid with high antioxidant activity. However, for biological applications, the bioavailability of quercetin is low due to physiological barriers. For this reason, an alternative is the protection of quercetin in matrices of biopolymers as zein. The objective of this work was to prepare and characterize quercetin‐loaded zein nanoparticles by electrospraying and its study of in vitro bioavailability. The physicochemical parameters such as viscosity, density, and electrical conductivity of zein solutions showed a dependence of the ethanol concentration. In addition, rheological parameters demonstrated that solutions of zein in aqueous ethanol present Newtonian behavior, rebounding in the formation of nanoparticles by electrospraying, providing spherical, homogeneous, and compact morphologies, mainly at a concentration of 80% (v/v) of ethanol and of 5% (w/v) of zein. The size and shape of quercetin‐loaded zein nanoparticles were studied by transmission electron microscopy (TEM), observing that it was entrapped, distributed throughout the nanoparticle of zein. Analysis by Fourier transform‐infrared (FT‐IR) of zein nanoparticles loaded with quercetin revealed interactions via hydrogen bonds. The efficacy of zein nanoparticles to entrap quercetin was particularly high for all quercetin concentration evaluated in this work (87.9 ± 1.5% to 93.0 ± 2.6%). The in vitro gastrointestinal release of trapped quercetin after 240 min was 79.1%, while that for free quercetin was 99.2%. The in vitro bioavailability was higher for trapped quercetin (5.9%) compared to free quercetin (1.9%), than of gastrointestinal digestion. It is concluded, that the electrospraying technique made possible the obtention of quercitin‐loaded zein nanoparticles increasing their bioavailability. Practical Application This type of nanosystems can be used in the food and pharmaceutical industry. Quercetin‐loaded zein nanoparticles for its improvement compared to free quercetin can be used to decrease the prevalence of chronic degenerative diseases by increasing of the bioavailability of quercetin in the bloodstream. Other application can be as an antioxidant system in functional foods or oils to increase shelf life.

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Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Rodríguez-Félix

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

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“…Among them, electrospraying, as a counterpart of electrospinning, is currently considered the gold standard process to prepare microspheres for drug delivery applications . Although different devices for controlled drug delivery have been successfully fabricated via coaxial configuration, the implementation of new setups based on the application of electrical forces to single‐fluid blending still represents a big challenge to minimize the electrofluidodynamic process complexity . Currently, new possibilities for the fabrication of advanced functional materials are emerging by the combination of electrofluidodynamics with other consolidated technologies (i.e., emulsion, self‐assembly) …”

Section: Introductionmentioning

confidence: 99%

Core/shell cellulose‐based microspheres for oral administration of Ketoprofen Lysinate

Guarino

Caputo

Calcagnile³

et al. 2018

J Biomed Mater Res

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Herein, we propose the fabrication of a new carrier with core/shell structure-inner core of cellulose acetate (CA) coated by a micrometric layer of chitosan (CS)-fabricated through an integrated process, which combines Electro Dynamic Atomization (EDA) and layer-by-layer (LbL) technique. We demonstrate that CA based microspheres possess a unique capability to relevantly retain the drugs-that is, Ketoprofen Lysinate (KL)-along the gastric tract, while providing a massive release along the intestine. CS shell slightly influences the morphology and water retention under different pH conditions, improving drug encapsulation without compromising drug release kinetics. In vitro studies in simulated gastric and intestine fluids (SGF, SIF) with physiological enzymes, show a moderate release of LSK during the first 2 h (ca. 20% at pH 2), followed by a sustained release during the next 6 h (ca. 80% at pH 7). The obtained results demonstrate that CA-based microspheres hold strong potential to be used as carriers for a delayed oral administration of anti-inflammatory drugs. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2636-2644, 2018.

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“…These variations include the applied solvents, the additive surfactants, salt little chemical molecules, lipid and also other polymers besides the filament-forming polymer matrices. The second is about the analogical innovation of similar technology, for example, the single-fluid electrospraying can be developed to two-fluid coaxial electrospraying, and to tri-fluid coaxial electrospraying [25][26][27][28][29]. The third is about innovation of analytical methods.…”

Section: The Increase Of Working Fluids In Electrospinning Is Excmentioning

confidence: 99%

Teaching Materials for Engineering Education in High School from the Increase of Working Fluids in Electrospinning

Li¹,

Zhu²,

Wang³

et al. 2018

Proceedings of the 2018 2nd International Conference on Management, Education and Social Science (ICMESS 2018)

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Abstract-Scientific innovation is often reflected in the engineering processes. On the contrary, the engineering processes hidden in advanced technologies can provide many vivid teaching materials for effective innovation and engineering educations to the college students in high school. In this paper, we conclude the advancement of electrospinning processes, which is fast developed from one-fluid blending process two decades before to two-fluid coaxial electrospinning, and now develops three-fluid tri-axial electrospinning. The increase of working fluids in electrospinning is useful for college students to provoke their interests in advanced nanotechnologies. Meanwhile, the increase of working fluids in electrospinning is also excellent teaching materials for the students to build linkages between their previous knowledge and new technologies, so deepening their comprehensions on them. What is more, the increase of working fluids in electrospinning is excellent teaching materials for the students to learn how to implement innovations all by themselves， such as engineering design innovation, analogical innovation, and innovation of analytical methods.

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Fabrication of sustained-release zein nanoparticles via modified coaxial electrospraying

Cited by 93 publications

References 67 publications

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Core/shell cellulose‐based microspheres for oral administration of Ketoprofen Lysinate

Teaching Materials for Engineering Education in High School from the Increase of Working Fluids in Electrospinning

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