Fabrication of sustainable hydrogels-based chitosan Schiff base and their potential applications

Abdalla, Taghreed; Nasr, Abir S.; Bassioni, Ghada; Harding, D. R.; Kandile, Nadia G.

doi:10.1016/j.arabjc.2021.103511

Cited by 28 publications

(12 citation statements)

References 66 publications

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“…These findings support the argument over the influence of different therapies, as well as the optimization of hydrogel preparation conditions [43]. Abdalla et al [45] created a Schiff base hydrogel by reacting chitosan with pyridinebased aldehyde and cross-linking it with epichlorohydrin. TEM characterizations were performed on the produced hydrogels.…”

Section: Characterization Techniques Of Chitosan Hydrogels 41 Structu...supporting

confidence: 67%

“…SEM analysis can indicate chitosan hydrogel miscibility and polymer mix compatibility with hydrogel matrix constituents. By Abdalla et al [45] created a Schiff base hydrogel by reacting chitosan with pyridinebased aldehyde and cross-linking it with epichlorohydrin. TEM characterizations were performed on the produced hydrogels.…”

Section: Characterization Techniques Of Chitosan Hydrogels 41 Structu...mentioning

confidence: 99%

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Update on Chitosan-Based Hydrogels: Preparation, Characterization, and Its Antimicrobial and Antibiofilm Applications

Thirupathi¹,

Raorane

Vanaraj

et al. 2022

Gels

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Chitosan is a prominent biopolymer in research for of its physicochemical properties and uses. Each year, the number of publications based on chitosan and its derivatives increases. Because of its comprehensive biological properties, including antibacterial, antioxidant, and tissue regeneration activities, chitosan and its derivatives can be used to prevent and treat soft tissue diseases. Furthermore, chitosan can be employed as a nanocarrier for therapeutic drug delivery. In this review, we will first discuss chitosan and chitosan-based hydrogel polymers. The structure, functionality, and physicochemical characteristics of chitosan-based hydrogels are addressed. Second, a variety of characterization approaches were used to analyze and validate the physicochemical characteristics of chitosan-based hydrogel materials. Finally, we discuss the antibacterial, antibiofilm, and antifungal uses of supramolecular chitosan-based hydrogels. This review study can be used as a base for future research into the production of various types of chitosan-based hydrogels in the antibacterial and antifungal fields.

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Section: Characterization Techniques Of Chitosan Hydrogels 41 Structu...supporting

confidence: 67%

Section: Characterization Techniques Of Chitosan Hydrogels 41 Structu...mentioning

confidence: 99%

Update on Chitosan-Based Hydrogels: Preparation, Characterization, and Its Antimicrobial and Antibiofilm Applications

Thirupathi¹,

Raorane

Vanaraj

et al. 2022

Gels

View full text Add to dashboard Cite

show abstract

“…XRD patterns of the pure materials and hydrogels were measured on an X-ray diffractometer (TD-3500 X-ray diffractometer, Shenzhen, China) using CuKα characteristic radiation at a voltage of 30 kV and a current of 20 mA [ 65 ]. Scanning was performed at a rate of 2°/min, and the scanning range of 2θ was 10° to 60° at room temperature.…”

Section: Methodsmentioning

confidence: 99%

Study of Hydroxypropyl β-Cyclodextrin and Puerarin Inclusion Complexes Encapsulated in Sodium Alginate-Grafted 2-Acrylamido-2-Methyl-1-Propane Sulfonic Acid Hydrogels for Oral Controlled Drug Delivery

Naeem

Zhu

et al. 2023

Gels

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Puerarin has been reported to have anti-inflammatory, antioxidant, immunity enhancement, neuroprotective, cardioprotective, antitumor, and antimicrobial effects. However, due to its poor pharmacokinetic profile (low oral bioavailability, rapid systemic clearance, and short half-life) and physicochemical properties (e.g., low aqueous solubility and poor stability) its therapeutic efficacy is limited. The hydrophobic nature of puerarin makes it difficult to load into hydrogels. Hence, hydroxypropyl-β-cyclodextrin (HP-βCD)-puerarin inclusion complexes (PIC) were first prepared to enhance solubility and stability; then, they were incorporated into sodium alginate-grafted 2-acrylamido-2-methyl-1-propane sulfonic acid (SA-g-AMPS) hydrogels for controlled drug release in order to increase bioavailability. The puerarin inclusion complexes and hydrogels were evaluated via FTIR, TGA, SEM, XRD, and DSC. Swelling ratio and drug release were both highest at pH 1.2 (36.38% swelling ratio and 86.17% drug release) versus pH 7.4 (27.50% swelling ratio and 73.25% drug release) after 48 h. The hydrogels exhibited high porosity (85%) and biodegradability (10% in 1 week in phosphate buffer saline). In addition, the in vitro antioxidative activity (DPPH (71%), ABTS (75%), and antibacterial activity (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa) indicated the puerarin inclusion complex-loaded hydrogels had antioxidative and antibacterial capabilities. This study provides a basis for the successful encapsulation of hydrophobic drugs inside hydrogels for controlled drug release and other purposes.

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“…A unique class of such hydrogels includes supramolecular hydrogels (described in detail in section ) which exhibit excellent dynamic behavior due to high association and dissociation rates of physical forces . Chemically formed hydrogels via click chemistry reactions such as Schiff base mechanisms can either be reversible or nonreversible. − In reversible reactions, the encapsulated bioactive elements are held together within the hydrogel network via dynamic covalent bonding. In contrast, the bioactive elements can be encapsulated via strictly nonreversible covalent bulk polymerization and free radical polymerization.…”

Section: Encapsulation and Release Of Bioactive Elementsmentioning

confidence: 99%

Multifunctional Composite Hydrogels for Bacterial Capture, Growth/Elimination, and Sensing Applications

Dsouza

Constantinidou

Arvanitis

et al. 2022

ACS Appl. Mater. Interfaces

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Hydrogels are cross-linked networks of hydrophilic polymer chains with a three-dimensional structure. Owing to their unique features, the application of hydrogels for bacterial/antibacterial studies and bacterial infection management has grown in importance in recent years. This trend is likely to continue due to the rise in bacterial infections and antimicrobial resistance. By exploiting their physicochemical characteristics and inherent nature, hydrogels have been developed to achieve bacterial capture and detection, bacterial growth or elimination, antibiotic delivery, or bacterial sensing. Traditionally, the development of hydrogels for bacterial/antibacterial studies has focused on achieving a single function such as antibiotic delivery, antibacterial activity, bacterial growth, or bacterial detection. However, recent studies demonstrate the fabrication of multifunctional hydrogels, where a single hydrogel is capable of performing more than one bacterial/antibacterial function, or composite hydrogels consisting of a number of single functionalized hydrogels, which exhibit bacterial/antibacterial function synergistically. In this review, we first highlight the hydrogel features critical for bacterial studies and infection management. Then, we specifically address unique hydrogel properties, their surface/network functionalization, and their mode of action for bacterial capture, adhesion/growth, antibacterial activity, and bacterial sensing, respectively. Finally, we provide insights into different strategies for developing multifunctional hydrogels and how such systems can help tackle, manage, and understand bacterial infections and antimicrobial resistance. We also note that the strategies highlighted in this review can be adapted to other cell types and are therefore likely to find applications beyond the field of microbiology.

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Fabrication of sustainable hydrogels-based chitosan Schiff base and their potential applications

Cited by 28 publications

References 66 publications

Update on Chitosan-Based Hydrogels: Preparation, Characterization, and Its Antimicrobial and Antibiofilm Applications

Update on Chitosan-Based Hydrogels: Preparation, Characterization, and Its Antimicrobial and Antibiofilm Applications

Study of Hydroxypropyl β-Cyclodextrin and Puerarin Inclusion Complexes Encapsulated in Sodium Alginate-Grafted 2-Acrylamido-2-Methyl-1-Propane Sulfonic Acid Hydrogels for Oral Controlled Drug Delivery

Multifunctional Composite Hydrogels for Bacterial Capture, Growth/Elimination, and Sensing Applications

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