Fabrication of stimulus-responsive diatom biosilica microcapsules for antibiotic drug delivery

Vasani, Roshan; Lošić, Dušan; Cavallaro, Alex; Voelcker, Nicolas H.

doi:10.1039/c5tb00648a

Cited by 87 publications

(66 citation statements)

References 32 publications

(42 reference statements)

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“…Having established that pSi‐POct‐PAAC exhibits a well‐defined switching behavior (swelling/collapse) in response to pH, this section will address if the composite can be used to deliver a model drug (LVX antibiotic) on‐demand in response to a pH stimulus. LVX is a fluoroquinolone showing fluorescence emissions at 454 nm when excited at 292 nm . The amount of LVX loaded into the pSi by the spin‐coating method prior to plasma polymer deposition was 182±19 ng mm −2 (30.8±3 μg mm −3 ).…”

Section: Resultsmentioning

confidence: 99%

“…Drug release measurements were performed using a fluorescence spectrometer (Agilent Technologies Cary Eclipse) fitted with a Peltier temperature control system. Fluorescence measurements of LVX were obtained using an excitation wavelength of 292 nm and an emission wavelength of 454 nm according to an established protocol . In a typical experiment, a quartz cuvette was first filled with 3 mL of buffer and placed into the spectrometer.…”

Section: Methodsmentioning

confidence: 99%

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On‐demand Antimicrobial Treatment with Antibiotic‐Loaded Porous Silicon Capped with a pH‐Responsive Dual Plasma Polymer Barrier

Vasani

Szili

Rajeev

et al. 2017

Chemistry An Asian Journal

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Chronic wounds are am ajor socio-economic problem. Bacterial infections in such wounds are am ajor contributor to lack of wound healing. An early indicator of wound infection is an increasei np Ho ft he wound fluid. Herein, we describe the development of ap H-responsive drug delivery device that can potentially be used for wound decontamination in situ and on-demand in response to an increaseint he pH of the wound environment. The devicei sb ased on ap orouss ilicon film that provides ar eservoir for encapsulation of an antibiotic within the pores. Loaded porous silicon is capped withd ual plasma polymer layers of poly(1,7-octadiene) and poly(acrylic acid), which provide ap H-responsive barrierf or on-demand releaseo ft he antibiotic. We demonstrate that release of the antibiotic is inhibited in aqueous buffer at pH 5, whereas the drug is released in as ustainable mannera tpH8.Importantly,the released drugwas bacteriostatic against the Pseudomonas aeruginosa woundp athogen. In the future,i ncorporation of the delivery device into wound dressings could potentially be utilized for non-invasive decontamination of wounds.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

On‐demand Antimicrobial Treatment with Antibiotic‐Loaded Porous Silicon Capped with a pH‐Responsive Dual Plasma Polymer Barrier

Vasani

Szili

Rajeev

et al. 2017

Chemistry An Asian Journal

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“…The three-dimensional nanoporous structure of diatom frustules consists mainly of silica nanoparticles, and the architecturewith layers and different sized pores -gives rise to several interesting material applications, e.g. nano-to micrometer scaled sieves [5] or drug carriers [6] , [7] as well as vectors for drug delivery [8] , protein adsorbents [9] and as photocatalysts [10] . Diatom frustules also show particular optical properties [11] , [12] , [13] , [14] , [15] , [16] , [17] making them interesting for several optical applications [18] .…”

Section: Introductionmentioning

confidence: 99%

Diatom frustules as a biomaterial: effects of chemical treatment on organic material removal and mechanical properties in cleaned frustules from two Coscinodiscus species

et al. 2016

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The three-dimensional structure of silica diatom frustules offers a great potential as nanoporous material for several nanotechnological applications, but the starting point for these applications is the ability to obtain clean frustules with sufficient mechanical strength and intact structure. Here, frustules from the diatoms Coscinodiscus centralis Ehrenberg and C. wailesii Gran et Angst are characterized with respect to their structural integrity, content of residual organic biomaterial and their mechanical properties after two cleaning methods using either hydrogen peroxide as oxidizing agent or a combination of a surfactant (sodium dodecyl sulphate) and a complexing agent. Fluorescence microscopy and energy dispersive spectroscopy (SEM/EDS) analysis revealed clear differences regarding the amount of organic residual within the frustules depending on the cleaning process, with little organic material left after the oxidizing method. This method, however, induced a partial cracking of the frustules suggesting an embrittlement due to the cleaning. Nanoindentation confirmed this and showed that the oxidizing method resulted in more brittle frustules compared to the surfactant/complexing method. More efficient cleaning of organic biomaterial may result in more fragile frustules, and the choice of cleaning method must be based on the planned application.

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“…The thermo‐responsive properties OEGAs and OEGMAs can be tuned by the side chain hydrophobicity (deriving from the number of EO repeat units), random copolymerization of polymers with different EO units, and the backbone hydrophobicity (acrylate vs. methacrylate) . In recent years, some thermo‐responsive materials derived from OEGAs and OEGMAs have been developed for drug delivery application . In a work reported by Ding et al, a series of thermo‐responsive side chains consisting of 2‐(2‐methoxyethoxy)ethyl methacrylate (MEO 2 MA) or 2‐(2‐(2‐methoxyethoxy)ethoxy)ethyl methacrylate (MEO 3 MA) was linked onto a poly( l ‐glutamate) (PLG) backbone through “click” reaction [Fig.…”

Section: Thermo‐responsive Nddssmentioning

confidence: 99%

Polymer-based drug delivery systems for cancer treatment

Guo

Wang

Xiao

et al. 2016

J. Polym. Sci. Part A: Polym. Chem.

113

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This review is focused on the chemical design and synthesis of polymer‐based drug delivery systems, in particular with stimuli‐responsive nanoplatforms for cancer treatment. We provide a brief description of the properties, synthesis and advantages of amphiphilic block copolymers, including polyether‐polyester and polyether‐polyanhydride. As for stimuli‐responsive polymers, we detail the recent innovative techniques for constructing smarter, more precise and optimally tuned nanocarriers that release drug in the disease site. This review is presented in the context of polymer science research, with special attention focused on the tailor‐made polymers containing specific chemical functionalities. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 3525–3550

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Fabrication of stimulus-responsive diatom biosilica microcapsules for antibiotic drug delivery

Abstract: Thermo-responsive drug release from diatom biosilica microcapsules is demonstrated for the first time using microcapsules modified with copolymers of oligoethylene glycol methacrylates.

Cited by 87 publications

References 32 publications

On‐demand Antimicrobial Treatment with Antibiotic‐Loaded Porous Silicon Capped with a pH‐Responsive Dual Plasma Polymer Barrier

On‐demand Antimicrobial Treatment with Antibiotic‐Loaded Porous Silicon Capped with a pH‐Responsive Dual Plasma Polymer Barrier

Diatom frustules as a biomaterial: effects of chemical treatment on organic material removal and mechanical properties in cleaned frustules from two Coscinodiscus species

Polymer-based drug delivery systems for cancer treatment

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