Fabrication of solid lipid nanoparticles-based patches of paroxetine and their <i>ex-vivo</i> permeation behaviour

Pervaiz, Fahad; Saba, Ayesha; Yasin, Haya; Buabeid, Manal; Noreen, Sobia; Khan, Abida Kalsoom; Murtaza, Ghulam

doi:10.1080/21691401.2023.2179631

Cited by 7 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The absorption peaks of GMS at 3316 cm −1 , 2914 cm −1 , 2851 cm −1 , and 1731 cm −1 were derived from the stretching vibration of -OH, -CH, -CH2-, and C=O [31][32][33]. The characteristic peak of AP does not appear in the spectrum of AP-NLC but is highly consistent with the peak position of GMS and the spectrum of blank NLC.…”

Section: Ft-ir Analysissupporting

confidence: 54%

“…The strong bands generated by the valence vibration of the hydroxyl group (-OH) at 3292 cm −1 , the stretching vibrations of the carbonyl group (C=O) at 1653 cm −1 and 1608 cm −1 , and the stretching vibration of the pyran ring (C-O-C) at 1355 cm −1 were classified as the characteristic absorption peaks of AP [ 30 ]. The absorption peaks of GMS at 3316 cm −1 , 2914 cm −1 , 2851 cm −1 , and 1731 cm −1 were derived from the stretching vibration of -OH, -CH, -CH2-, and C=O [ 31 , 32 , 33 ]. The characteristic peak of AP does not appear in the spectrum of AP-NLC but is highly consistent with the peak position of GMS and the spectrum of blank NLC.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Development of A Nanostructured Lipid Carrier-Based Drug Delivery Strategy for Apigenin: Experimental Design Based on CCD-RSM and Evaluation against NSCLC In Vitro

Wang,

Liu,

et al. 2023

Molecules

View full text Add to dashboard Cite

Non-small-cell lung cancer (NSCLC) is the main cause of cancer-related deaths worldwide, with a low five-year survival rate, posing a serious threat to human health. In recent years, the delivery of antitumor drugs using a nanostructured lipid carrier (NLC) has become a subject of research. This study aimed to develop an apigenin (AP)-loaded nanostructured lipid carrier (AP-NLC) by melt sonication using glyceryl monostearate (GMS), glyceryl triacetate, and poloxamer 188. The optimal prescription of AP-NLC was screened by central composite design response surface methodology (CCD-RSM) based on a single-factor experiment using encapsulation efficiency (EE%) and drug loading (DL%) as response values and then evaluated for its antitumor effects on NCI-H1299 cells. A series of characterization analyses of AP-NLC prepared according to the optimal prescription were carried out using transmission electron microscopy (TEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). Subsequent screening of the lyophilization protectants revealed that mannitol could better maintain the lyophilization effect. The in vitro hemolysis assay of this formulation indicated that it may be safe for intravenous injection. Moreover, AP-NLC presented a greater ability to inhibit the proliferation, migration, and invasion of NCI-H1299 cells compared to AP. Our results suggest that AP-NLC is a safe and effective nano-delivery vehicle that may have beneficial potential in the treatment of NSCLC.

show abstract

Section: Ft-ir Analysissupporting

confidence: 54%

Section: Resultsmentioning

confidence: 99%

Development of A Nanostructured Lipid Carrier-Based Drug Delivery Strategy for Apigenin: Experimental Design Based on CCD-RSM and Evaluation against NSCLC In Vitro

Wang,

Liu,

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

“…The receptor medium was kept warmed (32°C±0.5°C) with continuous magnetic stirring at 200 rpm. 47 The tested formulation was the REP-SLN-TDDS (2 mg REP) compared to an equipotent dose of the control formulation of unprocessed REP suspension. The designated formulations were introduced into the donor chamber.…”

Section: Methodsmentioning

confidence: 99%

Repaglinide–Solid Lipid Nanoparticles in Chitosan Patches for Transdermal Application: Box–Behnken Design, Characterization, and In Vivo Evaluation

Ali,

Namazi,

Elbadawy

et al. 2024

IJN

View full text Add to dashboard Cite

Background Repaglinide (REP) is an antidiabetic drug with limited oral bioavailability attributable to its low solubility and considerable first-pass hepatic breakdown. This study aimed to develop a biodegradable chitosan-based system loaded with REP–solid lipid nanoparticles (REP-SLNs) for controlled release and bioavailability enhancement via transdermal delivery. Methods REP-SLNs were fabricated by ultrasonic hot-melt emulsification. A Box–Behnken design (BBD) was employed to explore and optimize the impacts of processing variables (lipid content, surfactant concentration, and sonication amplitude) on particle size (PS), and entrapment efficiency (EE). The optimized REP-SLN formulation was then incorporated within a chitosan solution to develop a transdermal delivery system (REP-SLN-TDDS) and evaluated for physicochemical properties, drug release, and ex vivo permeation profiles. Pharmacokinetic and pharmacodynamic characteristics were assessed using experimental rats. Results The optimized REP-SLNs had a PS of 249±9.8 nm and EE of 78%±2.3%. The developed REP-SLN-TDDS demonstrated acceptable characteristics without significant aggregation of REP-SLNs throughout the casting and drying processes. The REP-SLN-TDDS exhibited a biphasic release pattern, where around 36% of the drug load was released during the first 2 h, then the drug release was sustained at around 80% at 24 h. The computed flux across rat skin for the REP-SLN-TDDS was 2.481±0.22 μg/cm 2 /h in comparison to 0.696±0.07 μg/cm 2 /h for the unprocessed REP, with an enhancement ratio of 3.56. The REP-SLN-TDDS was capable of sustaining greater REP plasma levels over a 24 h period ( p <0.05). The REP-SLN-TDDS also reduced blood glucose levels compared to unprocessed REP and commercial tablets ( p <0.05) in experimental rats. Conclusion Our REP-SLN-TDDS can be considered an efficient therapeutic option for REP administration.

show abstract

Multifaceted Applications of Solid Lipid: A Comprehensive Review

Patra,

Sahu,

Singha

et al. 2024

Biomedical Materials & Devices

View full text Add to dashboard Cite

Fabrication of solid lipid nanoparticles-based patches of paroxetine and their ex-vivo permeation behaviour

Cited by 7 publications

References 37 publications

Development of A Nanostructured Lipid Carrier-Based Drug Delivery Strategy for Apigenin: Experimental Design Based on CCD-RSM and Evaluation against NSCLC In Vitro

Development of A Nanostructured Lipid Carrier-Based Drug Delivery Strategy for Apigenin: Experimental Design Based on CCD-RSM and Evaluation against NSCLC In Vitro

Repaglinide–Solid Lipid Nanoparticles in Chitosan Patches for Transdermal Application: Box–Behnken Design, Characterization, and In Vivo Evaluation

Multifaceted Applications of Solid Lipid: A Comprehensive Review

Contact Info

Product

Resources

About