Fabrication of Silica Nanoparticles with Both Efficient Fluorescence and Strong Magnetization and Exploration of Their Biological Applications

Mahtab, Faisal; Yu, Yong; Lam, Jacky W. Y.; Liu, Jianzhao; Zhang, Bei; Lü, Ping; Zhang, Xixiang; Tang, Ben Zhong

doi:10.1002/adfm.201002572

Cited by 124 publications

(87 citation statements)

References 65 publications

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“…Magnetic nanoparticles can be incorporated into luminescent silica nanoparticles to obtain multifunctional materials with strong fluorescence and high magnetization, which show great potential applications such as selective cell imaging and magnetic resonance imaging . Other functional components such as DNA aptamer, and therapeutic drug molecules may be modified onto AIEgens‐functionalized inorganic materials to afford multifunctionalized nanomaterials, simultaneously coupled with imaging and therapeutic functions, thus may have profound impact on the development of AIEgens based materials in biomedical applications …”

Section: Applicationsmentioning

confidence: 99%

AIEgens‐Functionalized Inorganic‐Organic Hybrid Materials: Fabrications and Applications

2016

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Inorganic materials functionalized with organic fluorescent molecules combine advantages of them both, showing potential applications in biomedicine, chemosensors, light-emitting, and so on. However, when more traditional organic dyes are doped into the inorganic materials, the emission of resulting hybrid materials may be quenched, which is not conducive to the efficiency and sensitivity of detection. In contrast to the aggregation-caused quenching (ACQ) system, the aggregation-induced emission luminogens (AIEgens) with high solid quantum efficiency, offer new potential for developing highly efficient inorganic-organic hybrid luminescent materials. So far, many AIEgens have been incorporated into inorganic materials through either physical doping caused by aggregation induced emission (AIE) or chemical bonding (e.g., covalent bonding, ionic bonding, and coordination bonding) caused by bonding induced emission (BIE) strategy. The hybrid materials exhibit excellent photoactive properties due to the intramolecular motion of AIEgens is restricted by inorganic matrix. Recent advances in the fabrication of AIEgens-functionalized inorganic-organic hybrid materials and their applications in biomedicine, chemical sensing, and solid-state light emitting are presented.

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Section: Applicationsmentioning

confidence: 99%

AIEgens‐Functionalized Inorganic‐Organic Hybrid Materials: Fabrications and Applications

2016

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“…It is clear that the Fe 3 O 4 nanospheres in Fe 3 O 4 @SiO 2 −NH 2 −RhNPs are covered by a layer of silica shell, which provides the location for binding amino groups and Rh nanoparticles, as shown in Figure a. What's more, it can effectively prevent the agglomeration of the particles . When another layer of silica shell is encapsulated on the nanospheres, the interface of the layered structure can be easily distinguished (Figure c), where the Rh nanoparticles with an average diameter of about 3 nm are evenly dispersed.…”

Section: Resultsmentioning

confidence: 99%

Rh Catalyzed Selective Hydrogenation of Nitroarenes under Mild Conditions: Understanding the Functional Groups Attached to the Nanoparticles

Tian

Zhou

et al. 2019

ChemCatChem

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Modifying the surface of metal catalyst is a crucial subject for improving the heterogeneous metal catalysts. It is still a great challenge to understand the structure‐activity relationship (SAR) between the surface supporting groups and the metal particles. Herein, Rh NPs supported on the magnetic silica sphere with various functional groups (−NH2, −SH, −SO3H, −N=CH2, −Cl, −NHCOCH3 and −NHCH2Ph) have been prepared for catalytic hydrogenation of nitroarenes under atmospheric pressure at room temperature. We discover that the chemical state of Rh NPs depends on the supporting groups significantly. The electron‐donating functionalities can effectively elevate the Rh0/Rh3+ ratio, which increase the catalytic performance both in conversion and selectivity. The amino group decorated catalyst has such a good selectivity that no dechlorination reaction is observable in the hydrogenation of 2‐chloro‐3‐nitropyridine. What's more, by introducing magnetic Fe3O4 nuclei and mesoporous silica encapsulating layer, the catalyst can be recovered conveniently by an external magnet, and can be reused 10 cycles without any loss of activity.

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“…To improve their stability, it is common to include stabilizing agents in the reaction. They are usually polymers such as polyvinylpyrrolidone (PVP), dendrimers, polyaniline, and dextrans [87-93] which lower the surface energy and increase electrostatic repulsion, resulting in improved colloidal stability. Most IONPs used clinically, including Feridex, Combidex, Resovist, and Ferumoxytol, are made by the co-precipitation method using dextran and its derivatives as the coating materials [94, 95].…”

Section: Engineering Of Nanoparticles For Tumor Detectionmentioning

confidence: 99%

Nanoparticles for improving cancer diagnosis

Chen

Zhen

Todd

et al. 2013

Materials Science and Engineering: R: Reports

104

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Despite the progress in developing new therapeutic modalities, cancer remains one of the leading diseases causing human mortality. This is mainly attributed to the inability to diagnose tumors in their early stage. By the time the tumor is confirmed, the cancer may have already metastasized, thereby making therapies challenging or even impossible. It is therefore crucial to develop new or to improve existing diagnostic tools to enable diagnosis of cancer in its early or even pre-syndrome stage. The emergence of nanotechnology has provided such a possibility. Unique physical and physiochemical properties allow nanoparticles to be utilized as tags with excellent sensitivity. When coupled with the appropriate targeting molecules, nanoparticle-based probes can interact with a biological system and sense biological changes on the molecular level with unprecedented accuracy. In the past several years, much progress has been made in applying nanotechnology to clinical imaging and diagnostics, and interdisciplinary efforts have made an impact on clinical cancer management. This article aims to review the progress in this exciting area with emphases on the preparation and engineering techniques that have been developed to assemble “smart” nanoprobes.

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Fabrication of Silica Nanoparticles with Both Efficient Fluorescence and Strong Magnetization and Exploration of Their Biological Applications

Cited by 124 publications

References 65 publications

AIEgens‐Functionalized Inorganic‐Organic Hybrid Materials: Fabrications and Applications

AIEgens‐Functionalized Inorganic‐Organic Hybrid Materials: Fabrications and Applications

Rh Catalyzed Selective Hydrogenation of Nitroarenes under Mild Conditions: Understanding the Functional Groups Attached to the Nanoparticles

Nanoparticles for improving cancer diagnosis

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