Fabrication of photo-electrochemical biosensors for ultrasensitive screening of mono-bioactive molecules: the effect of geometrical structures and crystal surfaces

Akhtar, Naeem; Emran, Mohammed Y.; Shenashen, Mohamed A.; Khalifa, Hesham; Osaka, Tetsuya; Faheem, Ahmed; Homma, Takayuki; Kawarada, Hiroshi; El‐Safty, Sherif A.

doi:10.1039/c7tb01803g

Cited by 89 publications

(44 citation statements)

References 68 publications

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“…Accordingly, these materials are widely applied in many important fields. Among them, nickel oxide (NiO) is an important semiconductor functional material [2], which is widely used in lithium ion batteries [3], electrocatalysis [4], thermal catalysis [5], gas sensor [6], electrochemistry [7,8], optical sensor [9] and biosensors [10][11][12][13][14] fields. Therefore, the preparation of various mesoporous NiO nanomaterials has become a research hotspot.…”

Section: Introductionmentioning

confidence: 99%

HMT-Controlled Synthesis of Mesoporous NiO Hierarchical Nanostructures and Their Catalytic Role towards the Thermal Decomposition of Ammonium Perchlorate

Guan

2019

Applied Sciences

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In this work, mesoporous nickel oxide (NiO) hierarchical nanostructures were synthesized by a facile approach by hydrothermal reaction and subsequent calcination. The phase structure, microstructure, element composition, surface area, and pore size distribution of the as-prepared products were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and the Brunauer-Emmett-Teller (BET) technique. The precursor of Ni 3 (NO 3 ) 2 (OH) 4 nanosheet, Ni 3 (NO 3 ) 2 (OH) 4 microsphere, and Ni(HCO 3 ) 2 sub-microsphere was obtained by hydrothermal reaction at 160 • C for 4 h when the ratio of Ni 2+ /HMT (hexamethylenetetramine) was 2:1, 1:2, and 1:3, respectively. After calcination at 400 • C for 2 h, the precursors were completely transformed to mesoporous NiO hierarchical nanosheet, microsphere, and sub-microsphere. When evaluated as additives of the thermal decomposition of ammonium perchlorate (AP), these NiO nanostructures significantly reduce the decomposition temperature of AP, showing obvious catalytic activity. In particular, NiO sub-microsphere have the best catalytic role, which can reduce the high temperature decomposition (HTD) and low temperature decomposition (LTD) temperature by 75.2 and 19.1 • C, respectively. The synthetic approach can easily control the morphology and pore structure of the NiO nanostructures by adjusting the ratio of Ni 2+ /HMT in the reactants and subsequent calcination, which avoids using expensive templates or surfactant and could be intended to prepare other transition metal oxide. Supplementary Materials:The following are available online at www.mdpi.com/xxx/s1, Figure S1:EDS spectrum of (a) NiO nanosheet; (b) NiO sub-microsphere, Figure S2: (a) Low-magnification TEM image, (b) highmagnification TEM image; and (c) HRTEM image of the precursor of Ni3(NO3)2(OH)4 microsphere.

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Section: Introductionmentioning

confidence: 99%

HMT-Controlled Synthesis of Mesoporous NiO Hierarchical Nanostructures and Their Catalytic Role towards the Thermal Decomposition of Ammonium Perchlorate

Guan

2019

Applied Sciences

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“…Thus, the development of simple and inexpensive analytical methods for selective and sensitive detection of DA is of particular interest. The electrochemical method is a great approach for DA sensing because of its short time delay production, high sensitivity and selectivity, easy handling, and applicability in vitro/in vivo, and an inexpensive analytical technique . Selective detection of DA in biological and physiological fluids is an important issue because of the low concentration of DA compared with other coexisting molecules such as ascorbic acid (AA) and uric acid (UA) .…”

Section: Introductionmentioning

confidence: 99%

3D‐Ridge Stocked Layers of Nitrogen‐Doped Mesoporous Carbon Nanosheets for Ultrasensitive Monitoring of Dopamine Released from PC12 Cells under K⁺ Stimulation

Emran

Shenashen

Morita

et al. 2018

Adv Healthcare Materials

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3D-ridge nanosheets of N-doped mesoporous carbon (NMCS)-based electrodes are fabricated as ultrasensitive biosensors for in vitro monitoring of dopamine (DA) released from living cells. The large-scale ranges of dense-layered sheets are arranged linearly with a thickness of <10 nm, soft tangled edges, stocked layer arrangements, and tunable mesoporous frameworks with 3D orientations. The intrinsic features of the active interfacial surface of the electrode based on NMCS along with polarized surfaces, dense surface-charged matrices, fast electron transfer, and easy molecular diffusion, are present in the highly active electrode for biosensing applications. The designed electrode based on the NMCS shows high sensitivity and selectivity for DA sensing even in the presence of physiological interference molecules, such as ascorbic acid and/or uric acid, at a low applied potential of 0.25 V versus Ag/AgCl. The large-scale NMCS-based electrode shows low detection limits as low as 10 nmol L , wide linear range up to 0.5 mmol L , long-term stability for more than 15 d (relative standard deviation (RSD)= 5.8%), and a low cytotoxicity with high biocompatibility. The findings demonstrated that the NMCS-based electrode is a reliable modified electrode for ultratrace sensitivity of DA, which is secreted normally from dopaminergic cells (PC12) or under a stimulating agent (K ).

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“…In comparison with the parent KIT-6, the slight decrements in N 2 adsorption capacity and pore size indicated that some pores of KIT-6 were still occupied by Co oxide NPs. 45 – 47 X-ray photoelectron spectroscopy (XPS) was used to determine the valence state of Co (Fig. S3 † ).…”

Section: Resultsmentioning

confidence: 99%

Encapsulation of ultrafine metal-oxide nanoparticles within mesopores for biomass-derived catalytic applications

et al. 2018

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Fabrication of photo-electrochemical biosensors for ultrasensitive screening of mono-bioactive molecules: the effect of geometrical structures and crystal surfaces

Abstract: The controlled design of hierarchical CN-ST flowers is a key feature for creating biosensor surface electrodes for photo-electrochemical, ultrasensitive screening of mono-bioactive molecules.

Cited by 89 publications

References 68 publications

HMT-Controlled Synthesis of Mesoporous NiO Hierarchical Nanostructures and Their Catalytic Role towards the Thermal Decomposition of Ammonium Perchlorate

HMT-Controlled Synthesis of Mesoporous NiO Hierarchical Nanostructures and Their Catalytic Role towards the Thermal Decomposition of Ammonium Perchlorate

3D‐Ridge Stocked Layers of Nitrogen‐Doped Mesoporous Carbon Nanosheets for Ultrasensitive Monitoring of Dopamine Released from PC12 Cells under K⁺ Stimulation

Encapsulation of ultrafine metal-oxide nanoparticles within mesopores for biomass-derived catalytic applications

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Fabrication of photo-electrochemical biosensors for ultrasensitive screening of mono-bioactive molecules: the effect of geometrical structures and crystal surfaces

Abstract: The controlled design of hierarchical CN-ST flowers is a key feature for creating biosensor surface electrodes for photo-electrochemical, ultrasensitive screening of mono-bioactive molecules.

Cited by 89 publications

References 68 publications

HMT-Controlled Synthesis of Mesoporous NiO Hierarchical Nanostructures and Their Catalytic Role towards the Thermal Decomposition of Ammonium Perchlorate

HMT-Controlled Synthesis of Mesoporous NiO Hierarchical Nanostructures and Their Catalytic Role towards the Thermal Decomposition of Ammonium Perchlorate

3D‐Ridge Stocked Layers of Nitrogen‐Doped Mesoporous Carbon Nanosheets for Ultrasensitive Monitoring of Dopamine Released from PC12 Cells under K+ Stimulation

Encapsulation of ultrafine metal-oxide nanoparticles within mesopores for biomass-derived catalytic applications

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3D‐Ridge Stocked Layers of Nitrogen‐Doped Mesoporous Carbon Nanosheets for Ultrasensitive Monitoring of Dopamine Released from PC12 Cells under K⁺ Stimulation