Fabrication of novel Si-doped hydroxyapatite/gelatine scaffolds by rapid prototyping for drug delivery and bone regeneration

Martínez‐Vázquez, Francisco J.; Cabañas, M.V.; Paris, Juan L.; Lozano, Daniel; Vallet‐Regí, María

doi:10.1016/j.actbio.2014.12.021

Cited by 176 publications

(108 citation statements)

References 63 publications

(55 reference statements)

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“…17 Therefore, biocomposite scaffolds containing HA have been fabricated in previous studies. 18,19 Two biocompatible, poly(L-lactic acid) (PLLA) and PCL, nanofibrous scaffolds containing HA were synthesized and the effects of scaffolds on the proliferation and differentiation of MC3T3-E1 cells were investigated.…”

mentioning

confidence: 99%

Innovative biodegradable poly(L-lactide)/collagen/<br />hydroxyapatite composite fibrous scaffolds promote osteoblastic proliferation and differentiation

Zhou¹,

Liu²,

Ma³

et al. 2017

IJN

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The development of an artificial bone graft which can promote the regeneration of fractures or diseased bones is currently the most challenging aspect in bone tissue engineering. To achieve the purpose of promoting bone proliferation and differentiation, the artificial graft needs have a similar structure and composition of extracellular matrix. One-step electrospinning method of biocomposite nanofibers containing hydroxyapatite (HA) nanoparticles and collagen (Coll) were developed for potential application in bone tissue engineering. Nanocomposite scaffolds of poly(L-lactide) (PLLA), PLLA/HA, PLLA/Coll, and PLLA/Coll/HA were fabricated by electrospinning. The morphology, diameter, elements, hydrophilicity, and biodegradability of the composite scaffolds have been investigated. The biocompatibility of different nanocomposite scaffolds was assessed using mouse osteoblasts MC3T3-E1 in vitro, and the proliferation, differentiation, and mineralization of cells on different nanofibrous scaffolds were investigated. The results showed that PLLA/Coll/HA nanofiber scaffolds enhanced cell adhesion, spreading, proliferation, differentiation, mineralization, and gene expression of osteogenic markers compared to other scaffolds. In addition, the nanofibrous scaffolds maintained a stable composition at the beginning of the degradation period and morphology wastage and weight loss were observed when incubated for up to 80 days in physiological simulated conditions. The PLLA/Coll/HA composite nanofibrous scaffolds could be a potential material for guided bone regeneration.

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mentioning

confidence: 99%

Innovative biodegradable poly(L-lactide)/collagen/<br />hydroxyapatite composite fibrous scaffolds promote osteoblastic proliferation and differentiation

Zhou¹,

Liu²,

Ma³

et al. 2017

IJN

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“…The resulting scaffolds display a high percent of porosity and interconnectivity, easily controllable with enhanced mechanical properties in comparison to conventional scaffold processing ( Figure 4A) [92] . Thus, 3D scaffolds based on composites (ceramic-polymer) such as silicon doped hydroxyapatite (SiHA), and mesoporous bioactive glass such as ceramic and polycaprolactone (PCL) and gelatin as polymers have been carried out [93][94][95][96][97] . One of the advantages of RC is the possibility to integrate nanostructural features into micro-macrostructure matrices to fine-tune cellular responses.…”

Section: Robocasting (Rc)mentioning

confidence: 99%

Preventing bacterial adhesion on scaffolds for bone tissue engineering

Sánchez‐Salcedo¹,

Colilla²,

Izquierdo‐Barba³

et al. 2024

IJB

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Abstract:Bone implant infection constitutes a major sanitary concern which is associated to high morbidity and health costs. This manuscript focused on overviewing the main research efforts committed up to date to develop innovative alternatives to conventional treatments, such as those with antibiotics. These strategies mainly rely on chemical modifications of the surface of biomaterials, such as providing it of zwitterionic nature, and tailoring the nanostructure surface of metal implants. These surface modifications have successfully allowed inhibition of bacterial adhesion, which is the first step to implant infection, and preventing long-term biofilm formation compared to pristine materials. These strategies could be easily applied to provide three-dimensional (3D) scaffolds based on bioceramics and metals, of which its manufacture using rapid prototyping techniques was reviewed. This opens the gates for the design and development of advanced 3D scaffolds for bone tissue engineering to prevent bone implant infections. Keywords: Antibacterial adhesion, biofilm formation, zwitterionic surfaces, nanostructured surfaces, rapid prototyping 3D scaffolds, bone tissue engineering.

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“…Producing a special internal structure of the stent by 3D printing can releasing drugs continuously and constantly which avoid drug side effects caused by the rapid release. Current technologies have been able to 3D-printed bio-ceramics loaded with Rifampin, Vancomycin and calcium phosphate cement scaffolds loaded with bovine serum albumin (BSA)/vascular endothelial growth factor (VEGF) [35][36][37][38].…”

Section: Cell Printing Technologymentioning

confidence: 99%

Untitled

2015

Transl Perioper & Pain Med

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The difficult airways caused by congenital or acquired variations are one of the major challenges in clinical anesthesia. The airway tools, airway stents, patches and others nowadays are produced in fixed specification, with complex process, long cycle and poor tissue compatibility, which may increase the risk of infection and difficultly meet the airway variations and airway surgeries. In addition, young anesthesiologists need long time of training before they can independently deal with the difficulty airway. Three-dimensional (3D) bio-printing technology is a promising method in solving clinical airway problems. This article intends to make a summary and prospect of related areas. Keywords

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Fabrication of novel Si-doped hydroxyapatite/gelatine scaffolds by rapid prototyping for drug delivery and bone regeneration

Cited by 176 publications

References 63 publications

Innovative biodegradable poly(L-lactide)/collagen/<br />hydroxyapatite composite fibrous scaffolds promote osteoblastic proliferation and differentiation

Innovative biodegradable poly(L-lactide)/collagen/<br />hydroxyapatite composite fibrous scaffolds promote osteoblastic proliferation and differentiation

Preventing bacterial adhesion on scaffolds for bone tissue engineering

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