Fabrication of Novel Membranes for Biomedical Applications via Halidation of Poly(Methacrylic Acid‐co‐Methyl Methacrylate) and Crosslinking of Complementary Groups by PEG

Abstract

Fabrication of novel, biocompatible and stimuli‐responsive membranes based on the crosslinking of poly(methacrylic acid‐co‐methyl methacrylate) using polyethylene glycol as a crosslinking agent is accomplished in a two‐stage procedure. Membranes are fabricated by casting and curing of the reactive precursors in different reaction compositions and durations according to a three‐level factorial design‐of‐experiments. The resulting membranes were thoroughly characterized using SEM, FTIR spectroscopy, thermal analysis and swelling experiments. The thermal properties were improved and swelling behavior of the hydrogels assures its stimuli‐responsive nature. MTT‐assay and cytotoxicity evaluations of the fabricated membranes elucidate acceptable biocompatibility profiles.