Enhancing the mechanical properties and physical stability of biomimetic polymer hydrogels for micro-patterning and tissue engineering applications

Fathi, Ali; Sherry, Lance; Breen, A; Shirazi, Ali Negahi; Valtchev, Peter; Dehghani, Fariba

doi:10.1016/j.eurpolymj.2014.07.011

Cited by 21 publications

(18 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several authors have reported the synthesis and characterization of hybrid hydrogels based on synthetic polymers and GelMA [6, 7, 94-96]. For example, Hutson et al .…”

Section: Hybrid Hydrogels Based On Gelmamentioning

confidence: 99%

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

et al. 2015

View full text Add to dashboard Cite

Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical applications due to their suitable biological properties and tunable physical characteristics. Three dimensional (3D) GelMA hydrogels closely resemble some essential properties of native extracellular matrix (ECM) due to the presence of cell-attaching and matrix metalloproteinase responsive peptide motifs, which allow cells to proliferate and spread in GelMA-based scaffolds. GelMA is also versatile from a processing perspective. It crosslinks when exposed to light irradiation to form hydrogels with tunable mechanical properties which mimic the native ECM. It can also be microfabricated using different methodologies including micromolding, photomasking, bioprinting, self-assembly, and microfluidic techniques to generate constructs with controlled architectures. Hybrid hydrogel systems can also be formed by mixing GelMA with nanoparticles such as carbon nanotubes and graphene oxide, and other polymers to form networks with desired combined properties and characteristics for specific biological applications. Recent research has demonstrated the proficiency of GelMA-based hydrogels in a wide range of applications including engineering of bone, cartilage, cardiac, and vascular tissues, among others. Other applications of GelMA hydrogels, besides tissue engineering, include fundamental single-single cell research, cell signaling, drug and gene delivery, and bio-sensing.

show abstract

“…Several authors have reported the synthesis and characterization of hybrid hydrogels based on synthetic polymers and GelMA [6, 7, 94-96]. For example, Hutson et al .…”

Section: Hybrid Hydrogels Based On Gelmamentioning

confidence: 99%

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Conducting the synthesis in CO 2 gas expanded solution remarkably increased the fumarate crosslinking active site in the backbone of poly(lactide-ethylene oxide fumarate) (PLEOF) copolymer, hence, enhancing the mechanical properties and osteoblast cell adhesion and proliferation [ 135 , 136 ]. Interpenetrated polymer networks of PLEOF reinforced with gelatin and methacrylated gelatin were also synthesized with enhanced primary human osteoblast cell adhesion and proliferation [ 137 , 138 ]. As shown in Figure 2 , these interpenetrating polymer network structures were composed of micro (~20 μm), and macropores (540 μm) pores that promote the nutrient mass transfer and cell growth, respectively.…”

Section: Modification Of Polyestersmentioning

confidence: 99%

Biomedical Applications of Biodegradable Polyesters

et al. 2016

Self Cite

View full text Add to dashboard Cite

Abstract:The focus in the field of biomedical engineering has shifted in recent years to biodegradable polymers and, in particular, polyesters. Dozens of polyester-based medical devices are commercially available, and every year more are introduced to the market. The mechanical performance and wide range of biodegradation properties of this class of polymers allow for high degrees of selectivity for targeted clinical applications. Recent research endeavors to expand the application of polymers have been driven by a need to target the general hydrophobic nature of polyesters and their limited cell motif sites. This review provides a comprehensive investigation into advanced strategies to modify polyesters and their clinical potential for future biomedical applications.

show abstract

“…A dissolution test was carried out to evaluate the dissolution behaviors of silicon and protein components of the prepared gelatin hybrids during the in vitro degradation process . In brief, a defined amount of pre‐dried sample was immersed in 20 mL of PBS solution.…”

Section: Characterizationmentioning

confidence: 99%

Porous organosilicone modified gelatin hybrids with controllable and homogeneous in vitro degradation behaviors for potential application as skin regeneration scaffold

Zhang

Gao

et al. 2019

Polymer International

View full text Add to dashboard Cite

This work aims at investigating intensively the effects of organosilicone species and their dosage on the physicochemical and particularly the in vitro degradation properties of gelatin hybrids. We prepared various porous organosilicone modified gelatin hybrids with epoxy-polydimethylsiloxane (PDMS) and/or glycidoxypropyltrimethoxysilane (GPTMS) and further systematically investigated their degradation behaviors in simulated physiological environments. It was found that the chemical composition, thermal stability, crosslinking degree, mechanical properties and porous structure of the gelatin hybrids could be tuned by adjusting the amount of PDMS and GPTMS. More importantly, degradation rates of the gelatin hybrids were reduced with increasing content of GPTMS, implying that the degradation behaviors could be controlled by tailoring the chemical interaction between the gelatin and organosilicone moieties. In addition, gelatin hybrids modified with both PDMS and GPTMS (PGs-GE) were demonstrated as a homogeneous hybridization, and their maximum weight losses met the typical healing period of a normal skin wound. Noticeably, the P1G1-GE hybrid with PDMS to GPTMS molar ratio 1:1 exhibited appropriate weight loss, integrity of pore structure and synchronous dissolution of silicon and protein during the degradation process, indicating a homogeneous degradation behavior. Furthermore, both the original and degraded P1G1-GE hybrid exhibited favorable cytocompatibility in vitro. The findings will be helpful for further insight into the in vivo degradation of gelatin hybrids, suggesting their potential application as skin regeneration scaffolds.

show abstract

Enhancing the mechanical properties and physical stability of biomimetic polymer hydrogels for micro-patterning and tissue engineering applications

Cited by 21 publications

References 34 publications

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

Biomedical Applications of Biodegradable Polyesters

Porous organosilicone modified gelatin hybrids with controllable and homogeneous in vitro degradation behaviors for potential application as skin regeneration scaffold

Contact Info

Product

Resources

About