Fabrication of novel electrochemical immunosensor by mussel-inspired chemistry and surface-initiated PET-ATRP for the simultaneous detection of CEA and AFP

Photoinduced Organocatalyzed Atom Transfer Radical Polymerization (O-ATRP): Precision Polymer Synthesis Using Organic Photoredox Catalysis

“…For instance, Kong and co-workers used surface initiated O-ATRP to grow ferrocenylmethyl methacrylate polymers from surface-bound DNA on Au electrodes . Instead, Chen, Bain, and co-workers used surface initiated O-ATRP catalyzed by eosin Y to polymerize glycidyl methacrylate at the surface of carbon nanotubes, which were then used as nanoprobes to improve the detection of carcinoembryonic antigen and α-ferroprotein through an electrochemical method . Finally, in an example from the Sun group, immunoglobulin G imprinted polymers were prepared at the surface of a modified Au electrode using O-ATRP catalyzed by fluorescein .…”

“…178 Instead, Chen, Bain, and co-workers used surface initiated O-ATRP catalyzed by eosin Y to polymerize glycidyl methacrylate at the surface of carbon nanotubes, which were then used as nanoprobes to improve the detection of carcinoembryonic antigen and α-ferroprotein through an electrochemical method. 219 Finally, in an example from the Sun group, immunoglobulin G imprinted polymers were prepared at the surface of a modified Au electrode using O-ATRP catalyzed by fluorescein. 220 In each of these examples, the wide range of functionalities tolerated both within monomers and other components of the sensors highlights the incredible versatility of O-ATRP.…”

A highly sensitive silicon nanowire array sensor for joint detection of tumor markers CEA and AFP

“…In recent years, general clinical detection methods for AFP and CEA include enzyme-linked immunosorbent assay (ELISA), electrochemical immunoassay (ECIA) and chemiluminescence immunoassay (CLIA). [16][17][18][19]35 However, these methods have some shortcomings, such as low sensitivity, being timeconsuming, involving labels, and requiring expensive equipment. Therefore, it is significant to develop highly sensitive, real-time, label-free, and low-cost tumor marker detection technology.…”

An ultrasensitive electrochemical sensor for phospholipase C via signal amplification based on breathing ATRP and its application

“…14,15 As a "living"/controlled radical polymerization method, atom transfer radical polymerization (ATRP) is usually used to afford signal amplification by dynamic chain growth containing hundreds of repeating units. 16,17 For example, Wang et al 18 used metal-free photoinduced electron transfer-ATRP of glycidyl methacrylate as a signal amplification method to detect the carcinoembryonic antigen and α-fetoprotein. Hu et al 19 developed a dual signal amplification strategy based on ATRP of 2-hydroxyethyl methacrylate and gold nanoparticles for the sensitive determination of tumor markers.…”