A highly sensitive silicon nanowire array sensor for joint detection of tumor markers CEA and AFP

Lu, Ke; Liu, Chaoran; Wang, Gaofeng; Yang, Weihuang; Fan, Kai; Lazarouk, S. K.; Лабунов, В. А.; Dong, Lijun; Li, Dujuan; Yang, Xiupei

doi:10.1039/d2bm00555g

Cited by 10 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As previously shown, a wafer-level and highly controllable top-down preparation technique to fabricate individual SiNWs [30,31]. Low-cost and highly controllable SiNW arrays have also been successfully fabricated with the help of conventional microfabrication techniques.…”

Section: Introductionmentioning

confidence: 89%

High-precision silicon nanowire array sensor for quantitating ambient humidity and pH value

Yang,

Zheng,

Liu

et al. 2024

Phys. Scr.

Self Cite

View full text Add to dashboard Cite

This paper presents a high sensitivity silicon nanowire (SiNW) array sensor for precisely quantitating humidity and pH value. Well-aligned nanowires with ordered separation have been fabricated via low-cost and highly controllable traditional top-down fabrication techniques, which are fully compatible with complementary metal oxide semiconductor (CMOS) technology. Compared to bottom-up fabrication techniques, better reproducibility and stability in these procedure are indicated by fabrication results. The packaged SiNW array devices exhibit excellent linearity and repeatability when tested for humidity. Alternatively, the SiNW arrays give a quick and accurate reflection to hydrogen ion concentration after functionalized with APTES solution. Notably, the accuracy of the sensor can reach ±0.1 pH. To characterize the immunity and long-term stability of the sensor, the performance of the SiNW array sensor at different temperatures and times was investigated in detail. The test results show that the SiNW array sensor has excellent test performance in gas and liquid environments, and the design makes it more competitive than those of commercialized sensors.

show abstract

Section: Introductionmentioning

confidence: 89%

High-precision silicon nanowire array sensor for quantitating ambient humidity and pH value

Yang,

Zheng,

Liu

et al. 2024

Phys. Scr.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Silicon-based nanomaterials (fluorescent silicon NPs [ 157 , 158 ], silicon nanowires [ 159 ], and fluorescent silicon nanorods [ 160 ]) have been extensively applied in the diagnosis and treatment of tumors, relying on excellent biological safety and unique optical, electrical, and mechanical properties. Guo et al used fluorescent silicon NPs to simultaneously load chemotherapy drug DOX and small interfering RNA (siRNA) to construct a bi-functional silicon nanotherapy system, combining biological image-guided chemotherapy with gene therapy for cancer treatment [ 161 ].…”

Section: Biomaterials Used In Tumor Immunotherapymentioning

confidence: 99%

Emerging biomaterials for tumor immunotherapy

et al. 2023

View full text Add to dashboard Cite

Background The immune system interacts with cancer cells in various intricate ways that can protect the individual from overproliferation of cancer cells; however, these interactions can also lead to malignancy. There has been a dramatic increase in the application of cancer immunotherapy in the last decade. However, low immunogenicity, poor specificity, weak presentation efficiency, and off-target side effects still limit its widespread application. Fortunately, advanced biomaterials effectively contribute immunotherapy and play an important role in cancer treatment, making it a research hotspot in the biomedical field. Main body This review discusses immunotherapies and the development of related biomaterials for application in the field. The review first summarizes the various types of tumor immunotherapy applicable in clinical practice as well as their underlying mechanisms. Further, it focuses on the types of biomaterials applied in immunotherapy and related research on metal nanomaterials, silicon nanoparticles, carbon nanotubes, polymer nanoparticles, and cell membrane nanocarriers. Moreover, we introduce the preparation and processing technologies of these biomaterials (liposomes, microspheres, microneedles, and hydrogels) and summarize their mechanisms when applied to tumor immunotherapy. Finally, we discuss future advancements and shortcomings related to the application of biomaterials in tumor immunotherapy. Conclusion Research on biomaterial-based tumor immunotherapy is booming; however, several challenges remain to be overcome to transition from experimental research to clinical application. Biomaterials have been optimized continuously and nanotechnology has achieved continuous progression, ensuring the development of more efficient biomaterials, thereby providing a platform and opportunity for breakthroughs in tumor immunotherapy. Graphical Abstract

show abstract

“…Though the carcinoembryonic antigen (CEA) is mostly expressed in colorectal cancers (CRCs), including gastrointestinal, breast, and lung cancers, the elevation in the level of CEA is also a significant analytical indicator for liver metastasis, which is the leading cause of death from colorectal cancer [ 40 ]. The normal level of CEA in healthy adults is less than 5 ng/mL, but in a patient with metastatic liver cancer, there is a significant rise in the concentration of CEA [ 41 ]. Shao et al constructed a highly sensitive aptasensor for detecting CEA by utilizing the FRET mechanism between near-infrared carbon dots (NIR-CDs) and gold nanorods (AuNRs) [ 38 ] ( Figure 2 G).…”

Section: Förster Resonance Energy Transfer-based Biosensors For Liver...mentioning

confidence: 99%

Aptameric Fluorescent Biosensors for Liver Cancer Diagnosis

Park

Cho

Chueng³

et al. 2023

Biosensors

View full text Add to dashboard Cite

Liver cancer is a prevalent global health concern with a poor 5-year survival rate upon diagnosis. Current diagnostic techniques using the combination of ultrasound, CT scans, MRI, and biopsy have the limitation of detecting detectable liver cancer when the tumor has already progressed to a certain size, often leading to late-stage diagnoses and grim clinical treatment outcomes. To this end, there has been tremendous interest in developing highly sensitive and selective biosensors to analyze related cancer biomarkers in the early stage diagnosis and prescribe appropriate treatment options. Among the various approaches, aptamers are an ideal recognition element as they can specifically bind to target molecules with high affinity. Furthermore, using aptamers, in conjunction with fluorescent moieties, enables the development of highly sensitive biosensors by taking full advantage of structural and functional flexibility. This review will provide a summary and detailed discussion on recent aptamer-based fluorescence biosensors for liver cancer diagnosis. Specifically, the review focuses on two promising detection strategies: (i) Förster resonance energy transfer (FRET) and (ii) metal-enhanced fluorescence for detecting and characterizing protein and miRNA cancer biomarkers.

show abstract

A highly sensitive silicon nanowire array sensor for joint detection of tumor markers CEA and AFP

Abstract: Liver cancer is one of the malignant tumors with the highest fatality rate and the increasing incidence, which has no effective treatment plan. Early diagnosis and early treatment of liver...

Cited by 10 publications

References 34 publications

High-precision silicon nanowire array sensor for quantitating ambient humidity and pH value

High-precision silicon nanowire array sensor for quantitating ambient humidity and pH value

Emerging biomaterials for tumor immunotherapy

Aptameric Fluorescent Biosensors for Liver Cancer Diagnosis

Contact Info

Product

Resources

About