“…In contrast, as depicted in the inset (b) of Fig. 7 , the plot of peak currents versus the scan rate is not favorably linear which indicates the absence of adsorptive behavior 30 , 31 , 44 . Figure 7 CV responses of CuO/ZnO-DSDSHNM in 0.5 M NaOH at various scan rates ranging from 10 to 250 mVs −1 (10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 125, 150, 175, 200, 225 and 250 mVs −1 ) in 10 mM glucose.…”
Section: Resultsmentioning
confidence: 84%
“…6 c, bare GCE and ZnO-MS have no electrochemical activity for glucose detection. CuO-MS modified GCE has a weaker electrochemical activity and a lower sensitivity versus glucose concentration 44 in comparison to the CuO/ZnO-DSDSHNM. Comparing the responses of CuO and ZnO with our proposed hybrid material CuO/ZnO in Fig.…”
Section: Resultsmentioning
confidence: 95%
“…According to the SEM micrograph of the CuO microstructures, the formation of bean-like particles with an average diameter of 1.50 µm from small nanoparticulate blocks could be observed (Fig. 3 a) 44 . In the case of ZnO microstructures (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…3 C. The XRD pattern of CuO corresponds to the JCPDS # 00–045-0937. The diffraction peaks at 2θ values of 32.60, 35.60, 38.80, 48.92, 53.68, 58.40, 61.68, 66.48, 68.20, 72.72 and 75.28 could be indexed as (− 110), (002), (111), (− 202), (020), (202), (− 113), (− 311), (− 220), (311) and (− 222) planes, respectively 44 . According to diffractogram b, the ZnO XRD planes at 2θ values of 31.80, 34.40, 36.25, 47.50, 56.60, 62.95, 66.50 and 68.05 could be indexed as (100), (002), (101), (102), (110), (103), (200) and (201) planes in correspondence with JCPDS # 00–036-1451.…”
A high-performance non-enzymatic glucose sensor based on hybrid metal-oxides is proposed. Dumbbell-shaped double-shelled hollow nanoporous CuO/ZnO microstructures (CuO/ZnO-DSDSHNM) were prepared via the hydrothermal method using pluronic F-127 as a surfactant. This structure is studied by various physicochemical characterizations such as scanning electron microscopy, X-ray diffraction spectroscopy, inductively coupled plasma atomic emission spectroscopy, elemental mapping techniques, X-ray photoelectron spectroscopy, and transmission electron microscopy. This unique CuO/ZnO-DSDSHNM provides both a large surface area and an easy penetrable structure facilitating improved electrochemical reactivity toward glucose oxidation. The prepared CuO/ZnO-DSDSHNM was used over the glassy carbon electrode (GCE) as the active material for glucose detection and then coated by Nafion to provide the proposed Nafion/CuO/ZnO-DSDSHNM/GCE. The fabricated glucose sensor exhibits an extremely wide dynamic range from 500 nM to 100 mM, a sensitivity of 1536.80 µA mM−1 cm−2, a low limit of detection of 357.5 nM, and a short response time of 1.60 s. The proposed sensor also showed long-term stability, good reproducibility, favorable repeatability, excellent selectivity, and satisfactory applicability for glucose detection in human serum samples. The achieved high-performance glucose sensing based on Nafion/CuO/ZnO-DSDSHNM/GCE shows that both the material synthesis and the sensor fabrication methods have been promising and they can be used in future researches.
“…In contrast, as depicted in the inset (b) of Fig. 7 , the plot of peak currents versus the scan rate is not favorably linear which indicates the absence of adsorptive behavior 30 , 31 , 44 . Figure 7 CV responses of CuO/ZnO-DSDSHNM in 0.5 M NaOH at various scan rates ranging from 10 to 250 mVs −1 (10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 125, 150, 175, 200, 225 and 250 mVs −1 ) in 10 mM glucose.…”
Section: Resultsmentioning
confidence: 84%
“…6 c, bare GCE and ZnO-MS have no electrochemical activity for glucose detection. CuO-MS modified GCE has a weaker electrochemical activity and a lower sensitivity versus glucose concentration 44 in comparison to the CuO/ZnO-DSDSHNM. Comparing the responses of CuO and ZnO with our proposed hybrid material CuO/ZnO in Fig.…”
Section: Resultsmentioning
confidence: 95%
“…According to the SEM micrograph of the CuO microstructures, the formation of bean-like particles with an average diameter of 1.50 µm from small nanoparticulate blocks could be observed (Fig. 3 a) 44 . In the case of ZnO microstructures (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…3 C. The XRD pattern of CuO corresponds to the JCPDS # 00–045-0937. The diffraction peaks at 2θ values of 32.60, 35.60, 38.80, 48.92, 53.68, 58.40, 61.68, 66.48, 68.20, 72.72 and 75.28 could be indexed as (− 110), (002), (111), (− 202), (020), (202), (− 113), (− 311), (− 220), (311) and (− 222) planes, respectively 44 . According to diffractogram b, the ZnO XRD planes at 2θ values of 31.80, 34.40, 36.25, 47.50, 56.60, 62.95, 66.50 and 68.05 could be indexed as (100), (002), (101), (102), (110), (103), (200) and (201) planes in correspondence with JCPDS # 00–036-1451.…”
A high-performance non-enzymatic glucose sensor based on hybrid metal-oxides is proposed. Dumbbell-shaped double-shelled hollow nanoporous CuO/ZnO microstructures (CuO/ZnO-DSDSHNM) were prepared via the hydrothermal method using pluronic F-127 as a surfactant. This structure is studied by various physicochemical characterizations such as scanning electron microscopy, X-ray diffraction spectroscopy, inductively coupled plasma atomic emission spectroscopy, elemental mapping techniques, X-ray photoelectron spectroscopy, and transmission electron microscopy. This unique CuO/ZnO-DSDSHNM provides both a large surface area and an easy penetrable structure facilitating improved electrochemical reactivity toward glucose oxidation. The prepared CuO/ZnO-DSDSHNM was used over the glassy carbon electrode (GCE) as the active material for glucose detection and then coated by Nafion to provide the proposed Nafion/CuO/ZnO-DSDSHNM/GCE. The fabricated glucose sensor exhibits an extremely wide dynamic range from 500 nM to 100 mM, a sensitivity of 1536.80 µA mM−1 cm−2, a low limit of detection of 357.5 nM, and a short response time of 1.60 s. The proposed sensor also showed long-term stability, good reproducibility, favorable repeatability, excellent selectivity, and satisfactory applicability for glucose detection in human serum samples. The achieved high-performance glucose sensing based on Nafion/CuO/ZnO-DSDSHNM/GCE shows that both the material synthesis and the sensor fabrication methods have been promising and they can be used in future researches.
“…Furthermore, it has promising performance for point-of-care (POC) in label-free operation and simple miniaturization. Numerous studies have reported an increase in biosensing platform sensitivity and selectivity, which indicates that lowering the sensor detection limit toward specific target molecules is possible [ 23 , 24 , 25 , 26 ].…”
Electrochemical sensors are considered an auspicious tool to detect biomolecules (e.g., DNA, proteins, and lipids), which are valuable sources for the early diagnosis of diseases and disorders. Advances in electrochemical sensing platforms have enabled the development of a new type of biosensor, enabling label-free, non-destructive detection of viability, function, and the genetic signature of whole cells. Numerous studies have attempted to enhance both the sensitivity and selectivity of electrochemical sensors, which are the most critical parameters for assessing sensor performance. Various nanomaterials, including metal nanoparticles, carbon nanotubes, graphene and its derivatives, and metal oxide nanoparticles, have been used to improve the electrical conductivity and electrocatalytic properties of working electrodes, increasing sensor sensitivity. Further modifications have been implemented to advance sensor platform selectivity and biocompatibility using biomaterials such as antibodies, aptamers, extracellular matrix (ECM) proteins, and peptide composites. This paper summarizes recent electrochemical sensors designed to detect target biomolecules and animal cells (cancer cells and stem cells). We hope that this review will inspire researchers to increase their efforts to accelerate biosensor progress—enabling a prosperous future in regenerative medicine and the biomedical industry.
The COVID‐19 pandemic has continued to spread rapidly, and patients with diabetes are at risk of experiencing rapid progression and poor prognosis for appropriate treatment. Continuous glucose monitoring (CGM), which includes accurately tracking fluctuations in glucose levels without raising the risk of coronavirus exposure, becomes an important strategy for the self‐management of diabetes during this pandemic, efficiently contributing to the diabetes care and the fight against COVID‐19. Despite being less accurate than direct blood glucose monitoring, wearable noninvasive systems can encourage patient adherence by guaranteeing reliable results through high correlation between blood glucose levels and glucose concentrations in various other biofluids. This review highlights the trending technologies of glucose sensors during the ongoing COVID‐19 pandemic (2019–2020) that have been developed to make a significant contribution to effective management of diabetes and prevention of coronavirus spread, from off‐body systems to wearable on‐body CGM devices, including nanostructure and sensor performance in various biofluids. The advantages and disadvantages of various human biofluids for use in glucose sensors are also discussed. Furthermore, the challenges faced by wearable CGM sensors with respect to personalized healthcare during and after the pandemic are deliberated to emphasize the potential future directions of CGM devices for diabetes management.
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