Fabrication of nanoparticles using <i>Annona squamosa</i> leaf and assessment of its effect on liver (Hep G2) cancer cell line

Vanitha, V.; Hemalatha, S.; Pushpabharathi, N.; Amudha, P.; Jayalakshmi, M.

doi:10.1088/1757-899x/191/1/012010

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…Several studies on the anticancer activities of A. squamosa L. plants have been conducted [13][14][15][16][17][18][19][20][21][22][23][24][25][26]. However, these studies have not reported any cervical anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

Cervical anticancer activities of Annona squamosa Linn. leaf isolate

Swantara

Rita

Dira³

et al. 2022

Vet World

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Background and Aim: Cancer is one of the leading causes of death, the need for new anticancer herbal drugs is becoming more urgent considering the side effects of synthetic drugs. This study aimed to determine the anticancer activity of isolates derived from the methanol extract of Annona squamosa Linn. leaves and to identify the compounds that have an active effect against HeLa cells. Materials and Methods: The leaf metabolites of A. squamosa L. were extracted using methanol at room temperature (28°C) and were partitioned into n-hexane, chloroform, and n-butanol. The toxicity test of these extracts was conducted using a brine shrimp lethality assay. Furthermore, the most toxic extracts were separated and purified using silica gel column chromatography to yield four isolate fractions: FA, FB, FC, and FD. The most toxic isolates were tested for anticancer against HeLa cells, and their compounds were identified using liquid chromatography-mass spectrometry. Results: The results showed that the most toxic isolate with an LC50 value of 100.00 ppm had a potency similar to that of an anticancer agent with an IC50 value of 70.9021 ppm. Furthermore, the five compounds identified in this isolate include (6S, 7aR)-6-hydroxy-4,4,7a-trimethyl-6,7-dihydro-5H-1-benzofuran-2-one or loliolide, cocamidopropyl betaine, N-[3- (dimethylamino)propyl]dodecanamide or lauramidopropyl dimethylamine, linolenic acid, and 1-dodecyl-2-azepanone or laurocapram. Conclusion: It can be concluded that the leaf isolates of A. squamosa Linn. had shown anticancer activities against cervical cancer.

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Section: Introductionmentioning

confidence: 99%

Cervical anticancer activities of Annona squamosa Linn. leaf isolate

Swantara

Rita

Dira³

et al. 2022

Vet World

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“…Among all type of cancer, lung cancer is considered to be the most frequently occurring disease and the prevalence is high in men than women (Adebayor, 2010). The lung cancer is predominantly caused by smoking, nearly 90% of lung cancers are being reported due to smoking and studies show that smoking causes a high mortality rate (Vanitha et al, 2017). A further aspect is radon gas, certain chemicals inhaled and asbestos, have a high risk for lung cancer (Prakash et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Influence of Artocarpus heterophyllus in benzopyrene induced lung cancer

M¹

2022

JUSST

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Lung cancer a deadliest cancer worldwide and the most common cancer in the whole of Asia. The present study focused on the protective efficacy of Artocarpus heterophyllus in benzopyrene induced lung toxicity in C57BL/6 Mice. Mice were orally induced with benzopyrene and treated with hydroethanolic extract of spermoderm of Artocarpus heterophyllus (HESA) at a dose of (50mg/kg.b.wt and 100mg/kg.b.wt). The oral administration of HESA effectively suppressed lung cancer as revealed by the decrease in the extent of haematological parameters with concomitant decrease in the activities of serum markers. Significantly protein expressions of p53 and Bcl2 in the lung tissue were further confirmed that coadministration of the extract treatment however downregulated their expressions by decreasing the marker of positively stained cells and restored the histopathological alteration of lung tissue. Our results suggest that HESA can be used as a protective agent against benzopyrene induced lung cancer.

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“…A number of studies on the anticancer activity of A. squamosa have already been published (Pardhasaradhi et al 2004;Pandey and Barve 2011;Biba et al 2014;Wang et al 2014;Veerakumar et al 2016;Oo and Khine 2017;Sandeep and Mittal 2017;Vanitha et al 2017;Zahid et al 2018;Al-Ghazzawi 2019). However, no report has been made on its cervical anticancer activity with respect to the inhibition of the growth of HeLa cells.…”

Section: Introductionmentioning

confidence: 99%

Effect of the Methanol Extract of Annona squamosa Linn Leaf on Cervical Cancer

2022

Int J Vet Sci

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Anona squamosa Linn leaves methanol extract was tested for anticancer activity, and the active components were identified in this study. The brine shrimp lethality test (BSLT) was used to measure the chemicals toxicity of the A. squamosa leaves extracted at room temperature using methanol. An anticancer test on HeLa cells was also carried out using this hazardous extract. The identification of the active compounds was carried out by Gas chromatography-mass spectrometry. At an LC50 value of 26.30ppm the extract was toxic, while at 35.65, it showed anticancer activity. Furthermore, 15 compounds which were responsible for this anticancer activity were identified. They include: ethyl-diethylene glycol, 3,7-Dimethyl-6-octenal, 6-Octen-1-ol, 3,7-dimethyl-, 2,6-Octadien-1-ol, 3,7-dimethyl, 1-Methoxy-4- (1-propenyl) benzene, 2,6-Octadien-1-ol, 3,7-dimethyl-, acetate or Geranyl acetate, methyl-dodecanoic acid, methyl-tetradecanoic acid, methyl-hexadecanoic acid, n-Hexadecanoic acid, 7-Acethyl-6-ethyl-1,1,4,4-tetramethyltetralyn, methyl-9-Octadecenoic acid, 9,12-Octamethyl-decadienoic acid, 9,12-Octadecadienoic acid, and bis (2-ethylhexyl)-1,2-Benzenedicarboxylic acid. According to this study, A. squamosa leaves can be employed as a natural anticancer agent for cervical cancer.

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Fabrication of nanoparticles using Annona squamosa leaf and assessment of its effect on liver (Hep G2) cancer cell line

Cited by 5 publications

References 2 publications

Cervical anticancer activities of Annona squamosa Linn. leaf isolate

Cervical anticancer activities of Annona squamosa Linn. leaf isolate

Influence of Artocarpus heterophyllus in benzopyrene induced lung cancer

Effect of the Methanol Extract of Annona squamosa Linn Leaf on Cervical Cancer

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