Fabrication of nanoparticles for bone regeneration: new insight into applications of nanoemulsion technology

Kupikowska-Stobba, Barbara; Kasprzak, Mirosław Marek

doi:10.1039/d1tb00559f

Cited by 26 publications

(18 citation statements)

References 243 publications

(397 reference statements)

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“…These limitations have driven research toward the development of protective micro- and nanocarriers that shield the immobilized biomolecules from unfavorable external conditions. Due to the simplicity of the fabrication, the most popular biomolecule delivery vehicles are spherical polymeric carriers such as microspheres, microcapsules, and nanospheres. − Among spherical carriers, micro- and nanospheres made of biodegradable polymers such as poly(lactic acid) (PLA), PLGA, and alginate have found the broadest use in bone reconstruction. − The kinetics of protein release from these carriers can be adjusted to a specific application by tailoring the particle size, porosity, and degradation rate, which can be attained by proper selection of the carrier material and fabrication method . An important disadvantage of biodegradable nano- and microspheres is the limited control over the biomolecule delivery rate and initial burst release .…”

Section: Methods To Deliver Bioactive Moleculesmentioning

confidence: 99%

Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems

Szwed-Georgiou

Płociński

Kupikowska-Stobba

et al. 2023

ACS Biomater. Sci. Eng.

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Novel tissue regeneration strategies are constantly being developed worldwide. Research on bone regeneration is noteworthy, as many promising new approaches have been documented with novel strategies currently under investigation. Innovative biomaterials that allow the coordinated and wellcontrolled repair of bone fractures and bone loss are being designed to reduce the need for autologous or allogeneic bone grafts eventually. The current engineering technologies permit the construction of synthetic, complex, biomimetic biomaterials with properties nearly as good as those of natural bone with good biocompatibility. To ensure that all these requirements meet, bioactive molecules are coupled to structural scaffolding constituents to form a final product with the desired physical, chemical, and biological properties. Bioactive molecules that have been used to promote bone regeneration include protein growth factors, peptides, amino acids, hormones, lipids, and flavonoids. Various strategies have been adapted to investigate the coupling of bioactive molecules with scaffolding materials to sustain activity and allow controlled release. The current manuscript is a thorough survey of the strategies that have been exploited for the delivery of biomolecules for bone regeneration purposes, from choosing the bioactive molecule to selecting the optimal strategy to synthesize the scaffold and assessing the advantages and disadvantages of various delivery strategies.

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Section: Methods To Deliver Bioactive Moleculesmentioning

confidence: 99%

Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems

Szwed-Georgiou

Płociński

Kupikowska-Stobba

et al. 2023

ACS Biomater. Sci. Eng.

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“…The combination of nano-hydroxyapatite with an elastic biodegradable polymer, which mimics the organic materials of bone extracellular matrix, has been demonstrated to enhance viability, adhesion, and proliferation significantly. Osteogenic differentiation of cells seeded onto implants such as human mesenchymal stem cells (hMSCs), which is attributed to osteoinductive properties of hydroxyapatite nanomaterials [ 90 ]. Additionally, the NPs synthesized from hydroxyapatite and metal materials have significant bactericidal properties [ 91 ].…”

Section: Application Of Nps In Bone Regenerationmentioning

confidence: 99%

Osteoimmunomodulatory Nanoparticles for Bone Regeneration

et al. 2023

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Treatment of large bone fractures remains a challenge for orthopedists. Bone regeneration is a complex process that includes skeletal cells such as osteoblasts, osteoclasts, and immune cells to regulate bone formation and resorption. Osteoimmunology, studying this complicated process, has recently been used to develop biomaterials for advanced bone regeneration. Ideally, a biomaterial shall enable a timely switch from early stage inflammatory (to recruit osteogenic progenitor cells) to later-stage anti-inflammatory (to promote differentiation and terminal osteogenic mineralization and model the microstructure of bone tissue) in immune cells, especially the M1-to-M2 phenotype switch in macrophage populations, for bone regeneration. Nanoparticle (NP)-based advanced drug delivery systems can enable the controlled release of therapeutic reagents and the delivery of therapeutics into specific cell types, thereby benefiting bone regeneration through osteoimmunomodulation. In this review, we briefly describe the significance of osteoimmunology in bone regeneration, the advancement of NP-based approaches for bone regeneration, and the application of NPs in macrophage-targeting drug delivery for advanced osteoimmunomodulation.

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“…In contrast, the PIC method (also called emulsion inversion point method) [ 12 – 13 ] proceeds at constant temperature ( Figure 1b ). Here, the change in the curvature of the surfactant layer from negative to positive or vice versa is driven by the addition of water (which increases POE hydration) to a mixture of oil + surfactant to produce an O/W nanoemulsion [ 14 ].…”

Section: Reviewmentioning

confidence: 99%

Polymer nanoparticles from low-energy nanoemulsions for biomedical applications

Grijalvo¹,

Rodríguez‐Abreu²

2023

Beilstein J. Nanotechnol.

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The formulation of nanoemulsions by low-energy strategies, particularly by the phase inversion composition method, and the use of these nanoemulsions as templates for the preparation of polymer nanoparticles for biomedical applications are reviewed. The methods of preparation, nature of the components in the formulation, and their impact on the physicochemical properties, drug loading, and drug release are discussed. We highlight the utilization of ethyl cellulose, poly(lactic-co-glycolic acid), and polyurethane/polyurea in the field of nanomedicine as potential drug delivery systems. Advances are still needed to achieve better control over size distribution, nanoparticle concentration, surface functionalization, and the type of polymers that can be processed.

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Fabrication of nanoparticles for bone regeneration: new insight into applications of nanoemulsion technology

Abstract: This review discusses nanoemulsion technology as a tool for fabrication of nanoparticles for bone regeneration applications including hydroxyapatite nanoparticles, polymer nanoparticles for drug/biomolecule delivery and bone-targeting nanoparticles.

Cited by 26 publications

References 243 publications

Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems

Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems

Osteoimmunomodulatory Nanoparticles for Bone Regeneration

Polymer nanoparticles from low-energy nanoemulsions for biomedical applications

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