Fabrication of Nanohydroxyapatite/ Scrawl Collagen/Chitosan Composite for Bone Graft Candidate

Cahyaningrum, Sari Edi; Herdyastuti, Nuniek; Supangat, D.; Devina, B.; Kurniasari, Marlinda

doi:10.31788/rjc.2018.1121916

Cited by 7 publications

(4 citation statements)

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“…The CaO from calcination scrab shell will react with H 2 O to produce Calcium hydroxide solution. This solution was added with H 3 PO 4 solution with wise drop and single drop methods at 60 o C until solution pH 7 [7]. Synthesis HAp at less than 60 o C produces amorf structure, so that the synthesis HAp must do at 60 o C. The HAp crystal that produce in this research there are HAp single drop (HAp-SD), HAp wish drop (HAp-WD ) were analysis with some instruments compared with CaO Scrab shell (CaO-CK) and HAp Bank Jaringan (HAp-BJ).…”

Section: Resultsmentioning

confidence: 99%

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Synthesis of Hydroxyapatite from Crab Shell (Scylla serrata) Waste With Different Methods Added Phosphate

Cahyaningrum¹,

Herdyastuty²,

Wiana³

et al. 2018

Proceedings of the Seminar Nasional Kimia - National Seminar on Chemistry (SNK 2018)

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Hydroxyapatite (HAp) is the main material of bone structure which has chemical formula Ca10(PO4)6(OH)2. In this research, HAp synthesis use precursor calcium from crab shells and phosphate from H3PO4. Phosphate addition is done in single drop and wise drop. The calcinations of crab shell were done at 1000 °C for 5 hours. The FTIR analysis showed that there were functional groups of OH, CO3 2-, PO4 3and Ca-O. The XRD analysis of HAp showed that synthesis with wish drop method has the main phase of HAp and second phase is apatite carbonate. HAp that synthesized by single drop besides produce those phase also produce tricalcium bis(orthophosphate) phase. The synthesized HAp using the wise drop method has a larger surface area and pore volume but has a smaller pore size than that synthesis by using single drop method. The analyze morphology showed that HAp that synthesis using the wise drop method there is an agglomeration in morphology and the synthesis using single drop method has a smooth morphology with pores spread evenly

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Section: Resultsmentioning

confidence: 99%

“…Both of HAp also contains other phase in the form of carbonate apatite. Carbonate apatite come from Ion carbonate (CO3 2-) which is substituted into HAp [7]. According to research existence of carbonate which is substituted in HAp (apatite carbonate) will improve growth of cell of osteoblast in test of in vitro [8].…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Hydroxyapatite from Crab Shell (Scylla serrata) Waste With Different Methods Added Phosphate

Cahyaningrum¹,

Herdyastuty²,

Wiana³

et al. 2018

Proceedings of the Seminar Nasional Kimia - National Seminar on Chemistry (SNK 2018)

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“…The mature bone’s calcified matrix and its organic components like collagen and ground substance make it biocompatible and osteoconductive. [ 1 ] Autograft osteoconductive potential is primarily due to bone growth factors like Bone morphogenic proteins (BMPs). However, it has been observed that 10% to 39% of patients experience substantial donor site morbidity following autograft harvests.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Characterization of Novel Biomaterial Consisting of Biphasic Calcium Phosphate, Chitosan, Casein and Ethanolic Leaves Extract of Ormocarpum Cochinchinense

Somashekar

Sudhakar

Prakash

et al. 2023

Journal of Pharmacy and Bioallied Sciences

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Background: Bioceramics are widely used as a biomaterial to promote bone regeneration. Bone defect management requires the placement of bone grafts. Though there are many bone grafts available, these have certain limitations like limited supply and second surgical site morbidity. Phytochemicals in plants are known to have bone regeneration capacity and are used in traditional medicine for bone fracture healing. Objective: The purpose of the study was to create a novel biomaterial consisting of a composite of biphasic calcium phosphate (BCP), chitosan (CH), casein (CA), and ethanolic leaves extract of Ormocarpum Cochinchinense (OC) fabricated and characterized for physicochemical properties. Materials and Methods: BCP-CH-CA-OC material was prepared and immersed in Simulated body fluid (SBF) for 21 days. Physical properties were analysed through X-Ray diffraction (XRD), Fourier Transform Spectroscopy (FTIR), and Scanning Electron Microscopy with Energy dispersion spectroscopy (SEM/EDS). Mechanical properties were analysed by compressive strength and diametral tensile strength tests. Using BET (Brunauer-Emmett-Teller) analysis and Nano computed tomography (CT) scan, porosity measurements were made. Results: XRD did not show any significant change after immersion in SBF, indicating that the material was not under change and is stable. FTIR showed an increase in chitosan content, due to the loss of casein. SEM analysis showed the deposition of crystals and porous structure. EDS showed the deposition of minerals. Nano CT and BET analysis showed clinically significant porosity of 30%. Conclusion: The mechanical and physical properties of this novel biomaterial could be used in tissue engineering for the repair of bone defects in non-load-bearing areas. The physicochemical properties are at par with other materials used for the purpose of bone grafting. The novel biomaterial has the potential to be used in bone regenerative medicine in non-load-bearing applications.

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“…One of the techniques for healing of bone is use synthetic bone graft biomaterial. The good synthetic of bone graft have to biocompatible, bioactive, nontoxic, supporting the nature of and osteoconductive of osteoinductive [1][2] , beside that the bone graft to have composition and structure which is equal with bone, that is containing >69% calcium phosphate, especially hidroxsiapatite; 21% collagen; 9% water and 1% other component 3 . Hidroxyapatite as especial component have the power of unfavorable mechanic, brittle and breakable, so that in synthesis of synthetic bone graft, the hydroxyapatite has to be composite with other material.…”

Section: Introductionmentioning

confidence: 99%

Use of Hydroxyapatite from Eggshell as Raw Material for Synthesis Bone Graft

Cahyaningrum¹,

Herdyastuti²,

Devina³

et al. 2019

Orient. J. Chem

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In this research hydroxyapatite was synthezed from eggshell. The hydroxyapaptite was combined with Collagen and Chitosan for produce composite hydroxyapaptite/Coll/Chi by ex-situ methods. The composite HA/Coll/Chi was characterized such as a functional group and phase crystallinity and surface morphology. HA synthesized from the precursor calcium derived from eggshell reacted with H 3 PO 4 , HA sintered at 900 o C. Result from spectra Infra red analysis showed that there are functional group PO 4 3and OH-that characteristic for HA. The bonding of HA with chitosan and collagen was showed from as well as a shift wave number in the group C=O and NH 2 . Results of XRD analysis showed that compositon of chitosan has effect in crystalinity of bone graft.

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Fabrication of Nanohydroxyapatite/ Scrawl Collagen/Chitosan Composite for Bone Graft Candidate

Cited by 7 publications

References 0 publications

Synthesis of Hydroxyapatite from Crab Shell (Scylla serrata) Waste With Different Methods Added Phosphate

Synthesis of Hydroxyapatite from Crab Shell (Scylla serrata) Waste With Different Methods Added Phosphate

Physicochemical Characterization of Novel Biomaterial Consisting of Biphasic Calcium Phosphate, Chitosan, Casein and Ethanolic Leaves Extract of Ormocarpum Cochinchinense

Use of Hydroxyapatite from Eggshell as Raw Material for Synthesis Bone Graft

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