Peripheral ossifying fibroma (POF) is the most common reactive gingival lesion. The cause and pathology are well understood. Peripheral giant cell granuloma, pyogenic granuloma, fibroma, and peripheral fibroma are among the differential diagnoses. The confirmed diagnosis for POF is based on histopathological evidence. A healthy 49-year-old man with fibrous swelling in the lower left anterior region of his jaw is discussed in this case report. Excisional biopsy was performed utilizing a diode laser in pulse mode at 980 nm. The patient was monitored for a year, and there was no recurrence.
The herbal leaves were collected from forests near Hosur, Tamil Nadu, in February 2020. Plant botanist Dr. P Jayaraman of the Plant anatomy research center (PARC), West Tambaram, Chennai, confirmed the herb's species. Accession number Parc/2021/4408 was assigned to the voucher specimen. The herb belonged to species called Ormocarpum cochinchinense (OC), Family Fabaceae.
Background:
Bioceramics are widely used as a biomaterial to promote bone regeneration. Bone defect management requires the placement of bone grafts. Though there are many bone grafts available, these have certain limitations like limited supply and second surgical site morbidity. Phytochemicals in plants are known to have bone regeneration capacity and are used in traditional medicine for bone fracture healing.
Objective:
The purpose of the study was to create a novel biomaterial consisting of a composite of biphasic calcium phosphate (BCP), chitosan (CH), casein (CA), and ethanolic leaves extract of Ormocarpum Cochinchinense (OC) fabricated and characterized for physicochemical properties.
Materials and Methods:
BCP-CH-CA-OC material was prepared and immersed in Simulated body fluid (SBF) for 21 days. Physical properties were analysed through X-Ray diffraction (XRD), Fourier Transform Spectroscopy (FTIR), and Scanning Electron Microscopy with Energy dispersion spectroscopy (SEM/EDS). Mechanical properties were analysed by compressive strength and diametral tensile strength tests. Using BET (Brunauer-Emmett-Teller) analysis and Nano computed tomography (CT) scan, porosity measurements were made.
Results:
XRD did not show any significant change after immersion in SBF, indicating that the material was not under change and is stable. FTIR showed an increase in chitosan content, due to the loss of casein. SEM analysis showed the deposition of crystals and porous structure. EDS showed the deposition of minerals. Nano CT and BET analysis showed clinically significant porosity of 30%.
Conclusion:
The mechanical and physical properties of this novel biomaterial could be used in tissue engineering for the repair of bone defects in non-load-bearing areas. The physicochemical properties are at par with other materials used for the purpose of bone grafting. The novel biomaterial has the potential to be used in bone regenerative medicine in non-load-bearing applications.
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