Fabrication of nanocrystalline hydroxyapatite doped degradable composite hollow fiber for guided and biomimetic bone tissue engineering

The Influence of α‐Tricalcium Phosphate Nanoparticles and Microparticles on the Degradation of Poly(D,L‐lactide‐co‐glycolide)

“…For example, a hollow fiber membrane composed of PLGA producess more homogenous degradation as a result of the easy escape of degradation byproducts through fiber channels. [22] Autocatalysis reactions, on the other hand, can be reduced by buffering the acidic end groups of the oligomers. The incorporation of micrometer-sized alkaline CaPs that dissolve and neutralize the acidic local environment will have this effect.…”

Application of 3D printing technology in bone tissue engineering

“…The high-dimensional threedimensional pore structure and high porosity significantly increase the specific surface area of the stent, which can ensure cell attachment and nutrient transport, and facilitate the smooth discharge of cellular metabolic waste and scaffold degradation products. The study found scaffold can achieve cell attachment, angiogenesis, nutrient transport, and metabolic waste discharge should have porosity more than 90% [25,26].…”

Nano-Doped Matrices for Tissue Regeneration

“…The number and size of Ag nanoparticle on the matrix surface was found to continuously increase with the irradiation time, and that the particles with an average size of 21 nm exhibited a strong antimicrobial activity. Specific applications for bone tissue engineering were described by some works in 2006 and 2007, reporting the results obtained by fabricating doped matrices and testing their biological activity by immersing them in standard culture media and simulated body fluid (SBF), or evaluating their in vitro response with osteoblasts-like cells or with human mesenchymal stem cells (hMSCs) (Li et al, 2006;Gerhardt et al, 2007;Sui et al, 2007;Torres et al, 2007;Zhang et al, 2007). The first example of Li et al is constituted by electrospun silk fibroin scaffolds containing bone morphogenetic protein 2 (BMP-2) and nanoparticles of hydroxyapatite.…”

“…The authors finally proposed that the piezoelectric properties of such composites may provide the stimulatory cues necessary to promote neural cell function. (Zhang et al, 2007) and (Torres et al, 2007). Reproduced with permission from Elsevier…”