Fabrication of multifunctional mucoadhesive buccal patch for drug delivery applications

Abstract

Mucoadhesive buccal patch is a promising dosage form for a successful oral drug delivery, which provides unique advantages for various applications such as treatment of periodontal disease and postdental surgery disorders. The aim of this study is to synthesize a novel multifunctional mucoadhesive buccal patch in a multilayer reservoir design for therapeutic applications. The patches were fabricated through simultaneous electrospinning of chitosan/poly(vinylalcohol) (PVA)/ibuprofen and electrospraying of phenylalanine amino acid nanotubes (PhNTs) containing metronidazole into the electrospun mats through a layer‐by‐layer process. An electrospun poly(caprolactone) (PCL) was used as an impermeable backing layer to protect the mucoadhesive component from tongue movement and drug loss. Buccal patches were characterized using scanning electron microscopy (SEM) and field emission scanning electron microscopy (FESEM) and also evaluated in terms of physicomechanical parameters such as pH, weight, thickness, tensile strength, folding endurance, and mucoadhesive properties. The swelling index of the patches was examined with respect to the PVA/chitosan ratio. The effect of genipin addition to the electrospinning solution was also studied on mucoadhesive and swelling properties. The cell viability of buccal patches was assessed by methylthiazolydiphenyl‐tetrazolium bromide test on L929 fibroblast cell line. The patch with an optimal amount of mucoadhesive polymers (PVA/chitosan 80:20) and crosslinking agent (0.05 g) indicated an ideal hemostatic activity along with antibacterial properties against Streptococcus mutans bacteria. The synthesized multifunctional mucoadhesive patch with a novel composition and design has a great potential for oral therapeutic applications.

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

“…The adhesive layer not only serves as a drug carrier but also as a link between the drug-carrying layer and the nonadhesive layer. The bioadhesive buccal patch is the most suitable drug-delivery system for oral mucosa [ 107 ].…”

Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

“…The combined use of CS and PluronicF127 was successful in improving mucoadhesive power and in situ residence time of a metoprolol-loaded buccal patch, allowing a drug sustained release of up to 8 h [ 96 ]. An innovative multilayer buccal patch, obtained via a layer-by-layer process by electro-spraying of phenylalanine nanoparticles containing metronidazole into a mucoadhesive CS/polyvinyl alcohol/ibuprofen electro-spun patch was realized, which provided a controlled dual-release of the loaded drugs and showed good hemostatic activity and optimal antibacterial action [ 97 ].…”

Recent advances in functionally modified polymers for mucoadhesive drug delivery

“…Even so, non-ionic polymers are also generally used for mucoadhesive applications. Hydrophilic non-ionic polymers like hydroxypropyl methyl cellulose, 59 poloxamer, 60 polyvinyl alcohol, 61 starch, 62 pullulan 63 and polyvinyl pyrrolidone 64 are studied for their mucoadhesive properties. These hydrophilic polymers form highly viscous solutions in water 65 and cause interpenetrating interactions of polymer chains with mucin chains.…”