Fabrication of magnetic core/shell hydrogels via microfluidics for controlled drug delivery

Chen, Zhuo; Song, Shuang; Ma, Jing; Ling, Si Da; Wang, Yun Dong; Kong, Tian Tian; Xu, Jian

doi:10.1016/j.ces.2021.117216

Cited by 44 publications

(30 citation statements)

References 34 publications

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“…Under the effect of a magnetic field, SPIONs are vibrated, which leads to a magnetic hyperthermia, activation of the TRHs, and a change in their swelling state, thereby modulating the drug release rate [ 76 ]. Chen et al synthesized the SPIONs-incorporated poly(N-isopropyl acrylamide) as MRHs for the controlled release of the anti-cancer drug [ 77 ]. According to Fick’s law, they reported that when the magnetic field is cut off, the hydrogel undergoes a volume transition, and the loaded drug is released into the surrounding aqueous solution.…”

Section: Electrically and Magnetically Responsive Hydrogels (E And Mrhs)mentioning

confidence: 99%

Smart Hydrogels for Advanced Drug Delivery Systems

Bordbar‐Khiabani

Gasik

2022

IJMS

138

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Since the last few decades, the development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from their environments, has become a thriving research frontier in the biomedical engineering field. Nowadays, drug delivery systems have received great attention and smart hydrogels can be potentially used in these systems due to their high stability, physicochemical properties, and biocompatibility. Smart hydrogels can change their hydrophilicity, swelling ability, physical properties, and molecules permeability, influenced by external stimuli such as pH, temperature, electrical and magnetic fields, light, and the biomolecules’ concentration, thus resulting in the controlled release of the loaded drugs. Herein, this review encompasses the latest investigations in the field of stimuli-responsive drug-loaded hydrogels and our contribution to this matter.

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Section: Electrically and Magnetically Responsive Hydrogels (E And Mrhs)mentioning

confidence: 99%

Smart Hydrogels for Advanced Drug Delivery Systems

Bordbar‐Khiabani

Gasik

2022

IJMS

138

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“…Microfluidic technology can fabricate various hydrogels with sophisticated structure and uniform size, which could result in multiple drug delivery and stimulus-responsive release on demand. [13,89,117] In this section, single drug-loaded microgels for hydrophilic or hydrophobic small molecules and proteins, as well as multi-drug encapsulation systems and high drug-loading micrometer-sized hydrogels will be introduced (Figure 8).…”

Section: Drug Encapsulationmentioning

confidence: 99%

Microfluidics Fabrication of Micrometer‐Sized Hydrogels with Precisely Controlled Geometries for Biomedical Applications

Wei

Wang

Hirvonen

et al. 2022

Adv Healthcare Materials

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Micrometer‐sized hydrogels are cross‐linked three‐dimensional network matrices with high‐water contents and dimensions ranging from several to hundreds of micrometers. Due to their excellent biocompatibility and capability to mimic physiological microenvironments in vivo, micrometer‐sized hydrogels have attracted much attention in the biomedical engineering field. Their biological properties and applications are primarily influenced by their chemical compositions and geometries. However, inhomogeneous morphologies and uncontrollable geometries limit traditional micrometer‐sized hydrogels obtained by bulk mixing. In contrast, microfluidic technology holds great potential for the fabrication of micrometer‐sized hydrogels since their geometries, sizes, structures, compositions, and physicochemical properties can be precisely manipulated on demand based on the excellent control over fluids. Therefore, micrometer‐sized hydrogels fabricated by microfluidic technology have been applied in the biomedical field, including drug encapsulation, cell encapsulation, and tissue engineering. This review introduces micrometer‐sized hydrogels with various geometries synthesized by different microfluidic devices, highlighting their advantages in various biomedical applications over those from traditional approaches. Overall, emerging microfluidic technologies enrich the geometries and morphologies of hydrogels and accelerate translation for industrial production and clinical applications.

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“…The magnetic materials in this system must only act when the magnetic field is applied, and when the field is eliminated, it becomes inactive. Superparamagnetic nanoparticles having a single domain state smaller than 10 nm are known to have such magnetic characteristics [ 58 , 59 ]. The need to incorporate the benefits of MWCNTs (maximum load ability) and magnetic drug carriers (accurate delivery) to provide more precise medication to give a bigger amount of medication with more precision.…”

Section: Introductionmentioning

confidence: 99%