Fabrication of Ligusticum chuanxiong polylactic acid microspheres: A promising way to enhance the hepatoprotective effect on bioactive ingredients

Ge, Huifang; Lin, Peixuan; Luo, Taiduan; Yan, Zhiming; Xiao, Jianbo; Miao, Song; Chen, Jicheng

doi:10.1016/j.foodchem.2020.126377

Cited by 20 publications

(6 citation statements)

References 39 publications

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“…As an important dual-use resource of medicine and food, CX is more popular in the demand of natural products to promote people's health. 10 In the past, researchers often focused on the rhizomes of CX, ignoring the potential value of its other parts. This practice not only causes a serious waste of resources, but also is not conducive to the comprehensive development and utilization of CX resources.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive investigation on the chemical diversity and efficacy of different parts of Ligusticum chuanxiong

et al. 2022

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Section: Introductionmentioning

confidence: 99%

A comprehensive investigation on the chemical diversity and efficacy of different parts of Ligusticum chuanxiong

et al. 2022

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“…The effects of ligustrazine on pre-clinical studies are far from satisfactory. Recent study indicated that ligustrazinepolylactic acid (PLA) sustained-release microspheres might be a promising agent due to the characteristics of stable and sustained release effects on bioactive ingredients [21] . As PLA is emerging as an ideal drug carrier for its favorable biocompatibility and biodegradable [22] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Ligustrazine Nanoparticles on Th1/Th2 Balance by TLR4/MyD88/NF-κB Pathway in Rats with Postoperative Peritoneal Adhesion

Yang

Lian

Zhang³

et al. 2020

Preprint

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Background Postoperative peritoneal adhesion (PPA) is regarded as fibrous bands connecting both injured abdominal wall and organs or adjacent tissues and associated with T helper (Th)1 and Th2 differentiation. However, the critical role of immunopathogenesis of adhesion formation was precisely unknown. Previously we demonstrated that ligustrazine have positive effects on adhesion formation. And microarray analysis revealed TLR4/MyD88/NF-κB pathway as an important underlying regulatory mechanism in the onset and development of PPA. To further explore the possible mechanism of PPA and enhance the specificity of ligustrazine delivery to injured sites of rodent models, a new agent polylactic acid (PLA) nanoparticles loaded with ligustrazine, that is, ligustrazine nanoparticles (LN) were applied. Methods Twenty-four SD rats were randomly divided into sham, model, LN and sodium hyaluronate (SH) groups. The structure of LN, including entrapment efficiency (EE) and loading capacity (LC), and in vitro drug release were calculated. Adhesions were scored and the masson’s trichrome staining was used to determine the collagen deposition. The expression of TLR4, MyD88 and NF-κB were measured by qPCR, Immunohistochemistry and western blot assay. Moreover, Th1-related cytokines (IFN-γ, IL-12), Th2-related cytokines (IL-4, IL-6) in the cecum tissue and serum were conducted by ELISA. Results LN had good EE, LC and control-release delivery characters with fairly uniform diameter and spherical morphology. It could effectively prevent adhesion formation after surgery. Besides, it could reduce collagen fibers accumulation, downregulate the expression levels of TLR4, MyD88 and NF-κB, and maintain Th1/Th2 balance. Conclusions Ligustrazine nanoparticles had effective effects on Th1/Th2 balance by regualtingTLR4/MyD88/NF-κB pathway in PPA rats. It may be served as a promising therapy on postoperative adhesion formation.

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“…A pyrazine and its several derivants, such as tetramethylpyrazine, have been detected in Maotai, Laobaigan, Yanghe River Daqu, and Fenjiu. Tetramethylpyrazine is the main active ingredient of Rhizoma Ligustici Chuanxiong, a Chinese herbal that has long been used to treat liver disease and protect the liver from fibrosis (115,116). It has antioxidation properties and enhances triglyceride degradation.…”

Section: The Effects and Putative Mechanisms Of The Main Flavor Compo...mentioning

confidence: 99%

Effects of beer, wine, and baijiu consumption on non-alcoholic fatty liver disease: Potential implications of the flavor compounds in the alcoholic beverages

2023

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Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease and its global incidence is estimated to be 24%. Beer, wine, and Chinese baijiu have been consumed worldwide including by the NAFLD population. A better understanding of the effects of these alcoholic beverages on NAFLD would potentially improve management of patients with NAFLD and reduce the risks for progression to fibrosis, cirrhosis, and hepatocellular carcinoma. There is evidence suggesting some positive effects, such as the antioxidative effects of bioactive flavor compounds in beer, wine, and baijiu. These effects could potentially counteract the oxidative stress caused by the metabolism of ethanol contained in the beverages. In the current review, the aim is to evaluate and discuss the current human-based and laboratory-based study evidence of effects on hepatic lipid metabolism and NAFLD from ingested ethanol, the polyphenols in beer and wine, and the bioactive flavor compounds in baijiu, and their potential mechanism. It is concluded that for the potential beneficial effects of wine and beer on NAFLD, inconsistence and contrasting data exist suggesting the need for further studies. There is insufficient baijiu specific human-based study for the effects on NAFLD. Although laboratory-based studies on baijiu showed the antioxidative effects of the bioactive flavor compounds on the liver, it remains elusive whether the antioxidative effect from the relatively low abundance of the bioactivate compounds could outweigh the oxidative stress and toxic effects from the ethanol component of the beverages.

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Fabrication of Ligusticum chuanxiong polylactic acid microspheres: A promising way to enhance the hepatoprotective effect on bioactive ingredients

Abstract: Fabrication of Ligusticum chuanxiong polylactic acid microspheres: A promising way to enhance the hepatoprotective effect on bioactive ingredients, Food Chemistry (2020), doi:

Cited by 20 publications

References 39 publications

A comprehensive investigation on the chemical diversity and efficacy of different parts of Ligusticum chuanxiong

A comprehensive investigation on the chemical diversity and efficacy of different parts of Ligusticum chuanxiong

Effect of Ligustrazine Nanoparticles on Th1/Th2 Balance by TLR4/MyD88/NF-κB Pathway in Rats with Postoperative Peritoneal Adhesion

Effects of beer, wine, and baijiu consumption on non-alcoholic fatty liver disease: Potential implications of the flavor compounds in the alcoholic beverages

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