A comprehensive investigation on the chemical diversity and efficacy of different parts of <i>Ligusticum chuanxiong</i>

Yan, Hong-Ling; Zhou, Yinlin; Tang, Fei; Wang, Chengjiu; Wu, Jing; Hu, C.; Xie, Xing; Peng, Cheng; Tan, Yuzhu

doi:10.1039/d1fo02811a

Cited by 24 publications

(22 citation statements)

References 25 publications

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“…Based on these data, we can correlate the results observed in present study with the chemical constituents identified in the extract. However, compared with previous studies ( Yan et al, 2022 ), CXL and CXR showed higher radical scavenging capacity. These differences can be attributed to differences in geography, harvest time, storage methods, and different extraction procedures and solvents.…”

Section: Discussioncontrasting

confidence: 93%

“…In general, the aerial parts of plants are susceptible to biotic or abiotic stress, such as pests, herbivores, etc. Therefore, it is necessary to produce a higher level antioxidant metabolite for prevention, such as such as polyphenols and flavonoids ( Yan et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, Previous research has largely focused on the chemical composition and pharmacological activity of CX’s rhizomes ( Zhang et al, 2012 ; Li et al, 2014 ), ignoring the potential value of the leaves, which is not conducive to the comprehensive development and utilization of CX resources. Although studies have reported rhizomes of CX have rich phytochemicals with neuroprotective ( Ling, 2018 ) and anti-aging ( Jie et al, 2021 ) potential the leaves of CX possess the best antioxidant activity ( Yan et al, 2022 ), scarce literatures are available regarding the underlying molecular mechanisms of CX extract extending lifespan. Therefore, more detailed studies are needed to support these claims.…”

Section: Introductionmentioning

confidence: 99%

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Ligusticum chuanxiong Hort as a medicinal and edible plant foods: Antioxidant, anti-aging and neuroprotective properties in Caenorhabditis elegans

Qin

Chen²,

Tang³

et al. 2022

Front. Pharmacol.

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Ligusticum chuanxiong Hort. (CX) is a medicinal and edible plant including a variety of active substances, which may be an available resource for the treatment of related diseases. To expand the medicinal uses of CX, this study aims to explore the antioxidant, anti-aging and neuroprotective effects of the Ligusticum chuanxiong leaves (CXL) and rhizome (CXR) extracts. We first characterize CX phytochemical spectrum by LC-MS as well as antioxidant capacity. Acute toxicity, anti-oxidative stress capacity, lifespan and healthspan was evaluated in C elegans N2. Neuroprotective effect was evaluated in vitro and in vivo (C elegans CL4176 and CL2355). In this study, we detected 74 and 78 compounds from CXR and CXL, respectively, including phthalides, alkaloids, organic acids, terpenes, polyphenols and others. Furthermore, we found that CXs not only protect against oxidative stress, but also prolong the lifespan, alleviate lipofuscin, malondialdehyde (MDA) and reactive oxygen species (ROS) accumulation, and improve movement level, antioxidant enzyme activity in C elegans N2. However, only CXR reduced the β-amyloid peptide (Aβ)-induced paralysis phenotype in CL4176s and alleviated chemosensory behavior dysfunction in CL2355s. In addition, CXR treatment reduced the production of Aβ and ROS, enhanced SOD activity in CL4176s. The possible mechanism of anti-aging of CXL and CXR is to promote the expression of related antioxidant pathway genes, increase the activity of antioxidant enzymes, and reduce the accumulation of ROS, which is dependent on DAF-16 and HSF-1 (only in CXR). CXR was able to activate antioxidase-related (sod-3 and sod-5) and heat shock protein genes (hsp-16.1 and hsp-70) expression, consequently ameliorating proteotoxicity related to Aβ aggregation. In summary, these findings demonstrate the antioxidant, anti-aging and neuroprotective (only in CXR) activities of the CX, which provide an important pharmacological basis for developing functional foods and drugs to relieve the symptoms of aging and AD. However, the material basis of neuroprotective activity and antiaging effects need to be elucidated, and the relationship between these activities should also be clarified in future studies.

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Section: Discussioncontrasting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ligusticum chuanxiong Hort as a medicinal and edible plant foods: Antioxidant, anti-aging and neuroprotective properties in Caenorhabditis elegans

Qin

Chen²,

Tang³

et al. 2022

Front. Pharmacol.

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“…Although leaves and petioles of A. sinensis are not traditionally used as medicinal parts, they are rich in coumarins and other compounds, such as falcarindiol (Zschocke et al., 1998). A recent report of the chemical diversity and efficacy of different parts of Ligusticum chuanxiong proposed the sustainable exploitation of the non‐medicinal organs of L. chuanxiong (Yan et al., 2022). As the non‐medicinal parts of A. sinensis possess a number of bioactive ingredients and abundant diversity of coumarins, we recommend a comprehensive investigation of the chemical diversity and efficacy of different parts of A. sinensis aiming for full exploitation of the previously underutilized leaves and petioles, alleviating resource waste and environmental pressure.…”

Section: Discussionmentioning

confidence: 99%

The chromosome‐level genome of female ginseng (Angelica sinensis) provides insights into molecular mechanisms and evolution of coumarin biosynthesis

Han

Sun

et al. 2022

The Plant Journal

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SUMMARY Coumarins are natural products with important medicinal values, and include simple coumarins, furanocoumarins and pyranocoumarins. Female ginseng (Angelica sinensis) is a renowned herb with abundant coumarins, originated in China and known for the treatment of female ailments for thousands of years. The molecular basis of simple coumarin biosynthesis in A. sinensis and the evolutionary history of the genes involved in furanocoumarin biosynthesis are largely unknown. Here, we generated the first chromosome‐scale genome of A. sinensis. It has a genome size of 2.37 Gb, which was generated by combining PacBio and Hi‐C sequencing technologies. The genome was predicted to contain 43 202 protein‐coding genes dispersed mainly on 11 pseudochromosomes. We not only provided evidence for whole‐genome duplication (WGD) specifically occurring in the Apioideae subfamily, but also demonstrated the vital role of tandem duplication for phenylpropanoid biosynthesis in A. sinensis. Combined analyses of transcriptomic and metabolomic data revealed key genes and candidate transcription factors regulating simple coumarin biosynthesis. Furthermore, phylogenomic synteny network analyses suggested prenyltransferase genes involved in furanocoumarin biosynthesis evolved independently in the Moraceae, Fabaceae, Rutaceae and Apiaceae after ζ and ε WGD. Our work sheds light on coumarin biosynthesis, and provides a benchmark for accelerating genetic research and molecular breeding in A. sinensis.

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“…(CX), a medicine food homology plant of Umbelliferae, whose roots, Chuanxiong Rhizoma (CXR), is a traditional southeast Asian herb that is used clinically to treat chest pain, headache, irregular menstruation, etc. [ 1 , 2 ]. Chinese Pharmacopoeia (Ch.P.…”

Section: Introductionmentioning

confidence: 99%

An Underutilized Food “Miwu”: Diet History, Nutritional Evaluations, and Countermeasures for Industrial Development

Zou

Wang

Hou

et al. 2023

Foods

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About 10 major crops basically feed the world. In fact, there are still a large number of plants that have not been fully explored and utilized because they have been ignored by the market and research. The expansion of food sources in various countries plays an important role in maintaining food security and nutrition security in the world. Miwu is the aerial part of the medicinal plant Rhizoma Chuanxiong belonging to a traditional local characteristic food raw material. Its edible value is still little known. Through textual research, component determination, literature survey, field research, and SWOT analysis, this paper has a comprehensive understanding of Miwu’s diet history, chemical components, safety risks, and industrial development status. It is found that Miwu has been eaten for 800 years, is rich in nutrients and active ingredients, and has no acute toxicity. In addition, the current industrial development of Miwu has significant advantages and many challenges. To sum up, Miwu is a potentially underutilized food raw material. This paper also provides countermeasures for the industrialized development of Miwu, which will provide a milestone reference for the future utilization and development of Miwu.

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A comprehensive investigation on the chemical diversity and efficacy of different parts of Ligusticum chuanxiong

Abstract: Ligusticum chuanxiong Hort. (CX) is a medicinal and edible plant with a wide range of constituents of biological interest. Since the biomass of the non-medicinal parts of CX is huge,...

Cited by 24 publications

References 25 publications

Ligusticum chuanxiong Hort as a medicinal and edible plant foods: Antioxidant, anti-aging and neuroprotective properties in Caenorhabditis elegans

Ligusticum chuanxiong Hort as a medicinal and edible plant foods: Antioxidant, anti-aging and neuroprotective properties in Caenorhabditis elegans

The chromosome‐level genome of female ginseng (Angelica sinensis) provides insights into molecular mechanisms and evolution of coumarin biosynthesis

An Underutilized Food “Miwu”: Diet History, Nutritional Evaluations, and Countermeasures for Industrial Development

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