Fabrication of levofloxacin-loaded nanofibrous scaffolds using coaxial electrospinning

Park, Hongkwan; Yoo, Hyunhee; Hwang, Taewon; Park, Tae Joon; Paik, Dong Hyun; Choi, Sung Wook; Kim, Jung Hyun

doi:10.1007/s40005-012-0014-7

Cited by 19 publications

(7 citation statements)

References 23 publications

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“…When the ratio of the starch increases, the volume of beads would become larger, which will cause the average fibers diameter becomes larger and the fibers strength gets higher. Park et al [94] prepared levofloxacin-loaded CS and PCL nanofibers by coaxial electrospinning to control the release of antibiotics. They employed CS containing levofloxacin as a core, and PCL as a shell.…”

Section: Blending By Coaxial Electrospinningmentioning

confidence: 99%

Electrospun Functional Materials toward Food Packaging Applications: A Review

et al. 2020

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Electrospinning is an effective and versatile method to prepare continuous polymer nanofibers and nonwovens that exhibit excellent properties such as high molecular orientation, high porosity and large specific surface area. Benefitting from these outstanding and intriguing features, electrospun nanofibers have been employed as a promising candidate for the fabrication of food packaging materials. Actually, the electrospun nanofibers used in food packaging must possess biocompatibility and low toxicity. In addition, in order to maintain the quality of food and extend its shelf life, food packaging materials also need to have certain functionality. Herein, in this timely review, functional materials produced from electrospinning toward food packaging are highlighted. At first, various strategies for the preparation of polymer electrospun fiber are introduced, then the characteristics of different packaging films and their successful applications in food packaging are summarized, including degradable materials, superhydrophobic materials, edible materials, antibacterial materials and high barrier materials. Finally, the future perspective and key challenges of polymer electrospun nanofibers for food packaging are also discussed. Hopefully, this review would provide a fundamental insight into the development of electrospun functional materials with high performance for food packaging.

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Section: Blending By Coaxial Electrospinningmentioning

confidence: 99%

Electrospun Functional Materials toward Food Packaging Applications: A Review

et al. 2020

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“…The mitigation of burst release of a drug from coreshell structured nanofibres has been widely reported in the literature [17,27,43,44]. For example, Park et al [43] fabricated core-shell nanofibres and found that they considerably reduced the burst release of LVF compared to single-component nanofibres. This observation is presumably due to the confinement of the drug in the core section of the fibres and the outer layer serving as a diffusion barrier.…”

Section: Cumulative Release Of Lvfmentioning

confidence: 99%

Release and antimicrobial activity of levofloxacin from composite mats of poly(ɛ-caprolactone) and mesoporous silica nanoparticles fabricated by core–shell electrospinning

et al. 2015

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Nanofibrous materials have often been reported as carriers for clinical drugs but face the limitation of releasing the drugs in a burst fashion during use. The aim of this study is to produce composite nanofibrous mats with sustained release, using the broad spectrum antibiotic levofloxacin (LVF) as a model. Sustained release was achieved through two approaches, i.e. by firstly loading LVF into mesoporous silica nanoparticles (MSN) and then incorporating the MSN in the core regions of poly(ecaprolactone) (PCL) nanofibres via core-shell electrospinning. Uniform PCL/LVF nanofibrous mats were also produced as controls. Loading of LVF into the MSN nanopores was confirmed by FTIR, BJH and BET measurements (100 mg LVF/g MSN). After electrospinning, electron microscopy revealed that the MSN were indeed confined in the core regions of the nanofibres. Drug release profiles showed that burst release was decreased from 59 % in the uniform PCL/LVF electrospun mats to 39 % in the core-shell PCL/LVF-MSN mats after 1 day in phosphate buffer at 37°C, and gradual release in the latter was observed over the next 13 days. Antimicrobial assays showed that the composite electrospun mats were highly effective in killing Escherichia coli even after the mats had been incubated in a phosphate buffer for 14 days while the uniform PCL/LVF mats lost the ability after only 7 days. The results indicate that adsorption of the drug onto MSN and confining them in the core of nanofibres are effective ways of minimizing burst release and achieving sustained release of the drug.

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Section: Introductionmentioning

confidence: 99%

“…Nanofibers have been extensively investigated for various applications because of their unique structural properties, nanoscale effects, and large surface area . Electrospinning (ES) is the most efficient method to fabricate nanofibers and nanofibrous mats from various polymeric materials . In the ES process, electrically charged jets of a polymer solution are generated by applying a high voltage between the tip of a syringe containing the polymer and a cathode, yielding a nonwoven fabric‐like structure .…”

Section: Introductionmentioning

confidence: 99%

Fabrication and electrochemical instrumentation of redox‐active nanofiber mat for polyaniline incorporated with poly(imide sulfonate)

Shoji

Hatano

Hatashita

2019

Polymers for Advanced Techs

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In this study, we demonstrate the fabrication of an electrochemically active nanofiber mat that is a composite of high-performance poly(imide sulfonate) (PIS) and polyaniline (PANI). First, a nonconductive nanofiber mat comprising nanofibers having diameters of ca. 300 nm was fabricated by the electrospinning of ionomeric PIS in N,N-dimethylformamide (DMF). Then, the nanofibers were modified using PANI, which was synthesized by the oxidative polymerization of aniline, yielding an electrochemically active nanofiber mat having a diameter of ca. 350 nm. It was confirmed that PANI was successfully incorporated onto the PIS nanofiber mats by X-ray photoelectron spectroscopy. Subsequently, we conducted electrochemical measurements of the PANI-modified nanofiber mats using a tailor-made attachment in which the working electrode gently comes in contact with the nanofiber mat surface. This attachment was observed to be widely useful in the cyclic voltammetry measurements related to redox-active nanofibers. These observations are expected to contribute to the advancements in application development of the electrochemically active nanofiber mats.

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Fabrication of levofloxacin-loaded nanofibrous scaffolds using coaxial electrospinning

Cited by 19 publications

References 23 publications

Electrospun Functional Materials toward Food Packaging Applications: A Review

Electrospun Functional Materials toward Food Packaging Applications: A Review

Release and antimicrobial activity of levofloxacin from composite mats of poly(ɛ-caprolactone) and mesoporous silica nanoparticles fabricated by core–shell electrospinning

Fabrication and electrochemical instrumentation of redox‐active nanofiber mat for polyaniline incorporated with poly(imide sulfonate)

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