Fabrication of Hydrophilic Polymer Nanocontainers by Use of Supramolecular Templates

Abstract

Polymer-shelled vesicles are prepared by using cyclodextrin vesicles as supramolecular templates and an adamantane-functionalized poly(acrylic acid) additive anchored via host-guest recognition, followed by cross-linking of carboxylic acid groups on the polymer. The polymer-shelled nanocontainers are highly stable and effective for encapsulating small hydrophilic molecules. We also show that a hollow cross-linked polymer cage can be obtained after dissolution of the template vesicles. The size and shell thickness of the polymer cage can be tuned by variation of template size and polymer length.

Smart Nanocontainers: Preparation, Loading/Release Processes and Applications

“…In addition, the mixed (hybrid) metal-organic nanocontainers [12], nano-MOFs (metal-organic frameworks) [13,14] and gold/polymer core/shell [15][16][17], have also been achieved. The organic nanocontainers include polymeric [18][19][20][21][22][23][24] …”

Crosslinked polymer nanocapsules

“…They also studied the loading of hydrophobic monomer to the hydrophobic wall domains in the bilayer structure of liposome membranes, and their work suggested no considerable occurrence of fusion of liposomes during monomer loading . It should be noted that, based on electrostatic or other interactions, surfaces of liposomes can also be utilized to adsorb reagents to induce crosslinking polymerization for the preparation of CPNCs (Scheme (c)) …”

Reversible Stabilization of Vesicles: Redox‐Responsive Polymer Nanocontainers for Intracellular Delivery

“…[24,25] Along these lines,w eh ave recently shown that by anchoring adamantane functionalized poly(acrylic acid) (Ad-PAA) via host-guest recognition on the CDVs urface followed by crosslinking,h ighly stable polymer shelled vesicles (PSV) can be prepared. [26] Based on these results,w en ow use redox-responsive disulfide crosslinks to construct highly stable polymer shelled vesicles that should be sensitive to reducing conditions (PSV SS ,Scheme 1). In ar educing environment, these disulfide crosslinks should be cleaved resulting in ad iminished stabilization from the polymer shell to induce cargo release.…”