Crosslinked polymer nanocapsules

Sun, Hanwen; Chen, Chih‐Kuang; Cui, Honggang; Cheng, Chong

doi:10.1002/pi.5077

Cited by 29 publications

(20 citation statements)

References 139 publications

(272 reference statements)

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“…[ 11 ] In particular, polymers featuring for their insignificant toxicity, tailorable biodegradability, low immune response, and high chemical versatility have been extensively prepared to a myriad polymeric nano‐architectures such as nanoparticles (NPs), micelles, dendrimers, and nanocapsules (NCs), a unique type of NP with a hollow cavity, for delivering various therapeutic agents for combating cancer. [ 12–22 ] These polymer‐based carrier systems generally exhibited a needed drug loading capacity due to the proper polymer architectures. [ 13,23 ] Moreover, the surface of the carrier systems is capable of readily being loading with reactive functional groups for decorating required targeting moieties.…”

Section: Introductionmentioning

confidence: 99%

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

Yang

Lin

Chen

et al. 2021

Macromolecular Bioscience

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Since the conceptualization of nanomedicine, numerous nanostructure‐mediated drug formulations have progressed into clinical trials for treating cancer. However, recent clinical trial results indicate such kind of drug formulations has a limited improvement on the antitumor efficacy. This is due to the biological barriers associated with those formulations, for example, circulation stability, extravasation efficiency in tumor, tumor penetration ability, and developed multi‐drug resistance. When employing for nanomedicine formulations, pristine organic‐based and inorganic‐based nanostructures have their own limitations. Accordingly, organic/inorganic (O/I) hybrids have been developed to integrate the merits of both, and to minimize their intrinsic drawbacks. In this context, the recent development in O/I hybrids resulting from a self‐assembly strategy will be introduced. Through such a strategy, organic and inorganic building blocks can be self‐assembled via either chemical covalent bonds or physical interactions. Based on the self‐assemble procedure, the hybridization of four organic building blocks including liposomes, micelles, dendrimers, and polymeric nanocapsules with five functional inorganic nanoparticles comprising gold nanostructures, magnetic nanoparticles, carbon‐based materials, quantum dots, and silica nanoparticles will be highlighted. The recent progress of these O/I hybrids in advanced modalities for combating cancer, such as, therapeutic agent delivery, photothermal therapy, photodynamic therapy, and immunotherapy will be systematically reviewed.

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Section: Introductionmentioning

confidence: 99%

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

Yang

Lin

Chen

et al. 2021

Macromolecular Bioscience

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“…CPNCs can be prepared by template synthesis via cavitation of shell-crosslinked nanostructures, vesicle-based crosslinking, or emulsion-based interfacial crosslinking (Figure 1; Sun, Chen, Cui, & Cheng, 2016). Accuracy of template synthesis essentially is determined by template stability under reaction conditions.…”

Section: Synthetic Approaches Of Cpncsmentioning

confidence: 99%

Crosslinked polymer nanocapsules for therapeutic, diagnostic, and theranostic applications

Sun

Erdman

Yuan

et al. 2020

WIREs Nanomed Nanobiotechnol

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Crosslinked polymer nanocapsules (CPNCs) are hollowed nanoparticles with network-like polymeric shells stabilized by primary bonds. CPNCs have drawn broad and significant interests as nanocarriers for biomedical applications in recent years. As compared with conventional polymeric nanoparticles systems without cavity and/or crosslinking architectures, CPNCs possess significant biomedical relevant advantages, including (a) superior structural stability against environmental conditions, (b) high loading capacity and ability for region-specific loading of multiple cargos, (c) tuneable cargo release rate via crosslinking density, and (d) high specific surface area to facilitate surface adsorption, modification, and interactions. With appropriate base polymers and crosslinkages, CPNCs can be biocompatible and biodegradable. While CPNCbased biomedical nanoplatforms can possess relatively stable physicochemical properties owing to their crosslinked architectures, various biomedically relevant stimuli-responsivities can be incorporated with them through specific structural designs. CPNCs have been studied for the delivery of small molecule drugs, genes, proteins, and other therapeutic agents. They have also been investigated as diagnostic platforms for magnetic resonance imaging, ultrasound imaging, and optical imaging. Moreover, CPNCs have been utilized to carry both therapeutics and bioimaging agents for theranostic applications. This article reviews the therapeutic, diagnostic and theranostic applications of CPNCs, as well as the preparation of these CPNCs, reported in the past decade.

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“…On the other hand, they suggest that ultrasound might improve the tumor vessel permeability and drive nanosystems through the tumor vascular endothelial cells gap. 22,[44][45][46]…”

Section: In Vivo Biodistribution and Uorescence Imagingmentioning

confidence: 99%

A redox-sensitive core-crosslinked nanosystem combined with ultrasound for enhanced deep penetration of nanodiamonds into tumors

Hou

et al. 2020

RSC Adv.

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Crosslinked polymer nanocapsules

Abstract: The synthetic approaches for the preparation of crosslinked polymer nanocapsules are reviewed.

Cited by 29 publications

References 139 publications

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

Crosslinked polymer nanocapsules for therapeutic, diagnostic, and theranostic applications

A redox-sensitive core-crosslinked nanosystem combined with ultrasound for enhanced deep penetration of nanodiamonds into tumors

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