Fabrication of highly porous poly (ε-caprolactone) microfibers via electrospinning

Seo, Yuna; Pant, Hem Raj; Nirmala, R.; Lee, Ji-Hui; Song, Kyung Geun; Kim, Hee Young

doi:10.1007/s10934-011-9463-z

Cited by 34 publications

(22 citation statements)

References 23 publications

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“…These have been employed in several areas of tissue engineering and drug delivery (encapsulation and controlled drug release systems) (65)(66)(67). Various biodegradable (e.g.…”

Section: Porous Polymeric Carriersmentioning

confidence: 99%

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Porous Inorganic Drug Delivery Systems—a Review

et al. 2017

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Innovative methods and materials have been developed to overcome limitations associated with current drug delivery systems. Significant developments have led to the use of a variety of materials (as excipients) such as inorganic and metallic structures; marking a transition from conventional polymers. Inorganic materials, especially those possessing significant porosity, are emerging as good candidates for the delivery of a range of drugs (anti-biotics, anti-cancer and anti-inflammatories), providing several advantages in formulation and engineering (encapsulation of drug in amorphous form, controlled delivery and improved targeting). This review focuses on key selected developments in porous drug delivery systems. The review provides a short broad overview of porous polymeric materials for drug delivery before focusing on porous inorganic materials (e.g. Santa Barbara Amorphous (SBA) and Mobil Composition of Matter (MCM)) and their utilisation in drug dosage form development. Methods for their preparation and drug loading thereafter are detailed. Several examples of porous inorganic materials, drugs used and outcomes are discussed providing the reader with an understanding of advances in the field and realistic opportunities.

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“…These have been employed in several areas of tissue engineering and drug delivery (encapsulation and controlled drug release systems) (65)(66)(67). Various biodegradable (e.g.…”

Section: Porous Polymeric Carriersmentioning

confidence: 99%

“…Various biodegradable (e.g. PCL (65), poly (Llactic acid) (PLLA) (66), PLGA (68)) and non-biodegradable (e.g. polystyrene (69)) polymers has been used.…”

Section: Porous Polymeric Carriersmentioning

confidence: 99%

Porous Inorganic Drug Delivery Systems—a Review

et al. 2017

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“…The electrospinning conditions were 1.5 kV/cm at room temperature and the flow rates of the shell and core solutions were maintained at a ratio of 6:1 as suggested previously by Liao et al 34 Porous PCL fibers were created by electrospinning the fibers directly into a distilled/deionized water bath in a method described by Seo et al 35 After the collection of the core-shell fibers on the surface of the water bath for 15 min, the fibers were removed, washed thrice with PBS and incubated with EGM media at 37 °C. Core-shell fibers without cells were also fabricated under similar conditions and used as controls for this experiment.…”

Section: Coaxial Electrospinning Of Pcl/peo With Cellsmentioning

confidence: 99%

Characterization of a bioactive fiber scaffold with entrapped HUVECs in coaxial electrospun core-shell fiber

et al. 2014

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“…It is worth mentioning that due to the high porosity and outstanding specific surface area of porous structure, it can be used in various applications such as tissue engineering [28,29], drug delivery [30], water treatment applications [31][32][33][34], sensors [35,36], photocatalysis [37,38], lithium-ion batteries [39,40], energy harvesting [6], and so on [41][42][43]. To the best of our knowledge, few studies have investigated the generation of porous fibers using a bath collector [44][45][46]. In this work, the possibility of generating electrospun interconnected macroporous nanofibers from PS/chlorobenzene (CB)/N'N-dimethylformamide (DMF) solution at different solvent ratios (0:1, 1:3, 1:2, 1:1, 2:1, 3:1, and 4:1) and different temperatures of the bath collector (3, 25, and 40°C) were demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Direct generation of electrospun interconnected macroporous nanofibers using a water bath as a collector

Zhu

Zaarour

Jin

2020

Mater. Res. Express

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Porous nanofibers are of great significance to different applications. Herein, interconnected macroporous nanofibers were electrospun from polystyrene (PS)/chlorobenzene (CB)/N'Ndimethylformamide (DMF) using a bath collector. The effects of the solvent ratio and bath collector temperature on the structure of PS fibers are studied. The results showed that the presence of CB is essentials for the formation of porous fibers. Furthermore, the size of the pores on the surface of fibers increases by increasing the ratio of CB as well as decreasing the temperature of the bath collector. The formation mechanism of the interconnected macroporous structure is discovered. The BET test showed that these fibers had an outstanding specific surface area (SSA) of~44.27 m 2 g −1 . We believe our findings can be used as a good reference for the generation of electrospun nanofibers with interconnected macroporous using a water bath as a collector.

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Fabrication of highly porous poly (ε-caprolactone) microfibers via electrospinning

Cited by 34 publications

References 23 publications

Porous Inorganic Drug Delivery Systems—a Review

Porous Inorganic Drug Delivery Systems—a Review

Characterization of a bioactive fiber scaffold with entrapped HUVECs in coaxial electrospun core-shell fiber

Direct generation of electrospun interconnected macroporous nanofibers using a water bath as a collector

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