Fabrication of fillable microparticles and other complex 3D microstructures

McHugh, Kevin J.; Nguyen, Thanh D.; Linehan, Allison R.; Yang, Deng‐Tao; Behrens, Adam M.; Rose, Sviatlana; Tochka, Zachary L.; Tzeng, Stephany Y.; Norman, James J.; Anselmo, Aaron C.; Xu, Xiaojie; Tomasic, Stephanie; Taylor, Matthew; Lu, Jennifer; Guarecuco, Rohiverth; Langer, Robert; Jaklenec, Ana

doi:10.1126/science.aaf7447

Cited by 168 publications

(150 citation statements)

References 30 publications

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“…We used position‐registered conductive microparticles (MPs) to achieve the one‐selector device structure. Research on the arrangement and application of assembled MPs has been conducted over the past three decades, but there has been no report showing the feasibility of MP‐based integrated electronic devices. This is because it is difficult to assemble the MPs in a large area with accurate position registration and the concept of using the MPs in the electronic devices has not been developed yet.…”

Section: Introductionmentioning

confidence: 99%

E‐Skin Tactile Sensor Matrix Pixelated by Position‐Registered Conductive Microparticles Creating Pressure‐Sensitive Selectors

You

Choi

Hwang

et al. 2018

Adv Funct Materials

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Electronic skin (E-skin) imitates human skin by converting external stimuli into electrical signals. E-skin requires high flexibility and a high level of device integration. Unlike conventional E-skin creation methods, a highly sensitive pressure sensor matrix (100 pixels cm −2 ) made of position-registered elastic conductive microparticles (MPs) is created. The MPs form a Schottky junction with the bottom electrode and the current through the junction is sensitive to external pressure, forming a simple one-selector two-terminal device array. The Schottky junction eliminates the electrical cross talks between the sensor pixels consisting of 64 MPs in each. The flexible pressure sensor matrix is used as an artificial fingertip for Braille reading and as an electronic scale based on detailed force distribution. This work opens up the possibility that assembled MPs, which have been a long-standing research topic in academia, can be used to make practical electronic devices.

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Section: Introductionmentioning

confidence: 99%

E‐Skin Tactile Sensor Matrix Pixelated by Position‐Registered Conductive Microparticles Creating Pressure‐Sensitive Selectors

You

Choi

Hwang

et al. 2018

Adv Funct Materials

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“…In terms of engineering the kinetics for vaccines by auto-boosting technologies, the practicality of receiving doses on short time scales is increasingly more reasonable. New technologies such as SEAL [161] are seriously needed and are likely to be highly impactful. Potential complications such as the junction of the seal must be mitigated to the extent possible, however.…”

Section: Discussionmentioning

confidence: 99%

Engineering DNA vaccines against infectious diseases

et al. 2018

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Engineering vaccine-based therapeutics for infectious diseases is highly challenging, as trial formulations are often found to be nonspecific, ineffective, thermally or hydrolytically unstable, and/or toxic. Vaccines have greatly improved the therapeutic landscape for treating infectious diseases and have significantly reduced the threat by therapeutic and preventative approaches. Furthermore, the advent of recombinant technologies has greatly facilitated growth within the vaccine realm by mitigating risks such as virulence reversion despite making the production processes more cumbersome. In addition, seroconversion can also be enhanced by recombinant technology through kinetic and nonkinetic approaches, which are discussed herein. Recombinant technologies have greatly improved both amino acid-based vaccines and DNA-based vaccines. A plateau of interest has been reached between 2001 and 2010 for the scientific community with regard to DNA vaccine endeavors. The decrease in interest may likely be attributed to difficulties in improving immunogenic properties associated with DNA vaccines, although there has been research demonstrating improvement and optimization to this end. Despite improvement, to the extent of our knowledge, there are currently no regulatory body-approved DNA vaccines for human use (four vaccines approved for animal use). This article discusses engineering DNA vaccines against infectious diseases while discussing advantages and disadvantages of each, with an emphasis on applications of these DNA vaccines. STATEMENT OF SIGNIFICANCE: This review paper summarizes the state of the engineered/recombinant DNA vaccine field, with a scope entailing "Engineering DNA vaccines against infectious diseases". We endeavor to emphasize recent advances, recapitulating the current state of the field. In addition to discussing DNA therapeutics that have already been clinically translated, this review also examines current research developments, and the challenges thwarting further progression. Our review covers: recombinant DNA-based subunit vaccines; internalization and processing; enhancing immune protection via adjuvants; manufacturing and engineering DNA; the safety, stability and delivery of DNA vaccines or plasmids; controlling gene expression using plasmid engineering and gene circuits; overcoming immunogenic issues; and commercial successes. We hope that this review will inspire further research in DNA vaccine development.

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“…Unconventional device fabrication processes have garnered strong interests in recent years to pattern structures otherwise difficult to obtain with established techniques, such as complex 3D microstructures, high‐resolution patterning of solution processable materials, and patterns on uneven or nonplanar surfaces . Here, we further demonstrate the versatility of the CPR to fabricate structures in confined spaces, which is technically challenging with existing methods including metal‐pattern transfer and other novel printing techniques.…”

mentioning

confidence: 82%

Density Modulation of Embedded Nanoparticles via Spatial, Temporal, and Chemical Control Elements

et al. 2019

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Nanoparticle polymer composites have enabled material multifunctionalities that are difficult to obtain otherwise. A simple modification to a commercially available resin system enables a universal methodology to embed nanoparticles in resins via spatial, temporal, thermal, concentration, and chemical control parameters. Changes in nanoparticle density distribution are exploited to demonstrate dynamic optical and electronic properties that can be processed on‐demand, without the need for expensive equipment or cleanroom facilities. This strategy provides access to the control of optical (cooperative plasmonic effects), electronic (insulator to a conductor), and chemical parameters (multimetal patterning). Using the same composite resin system, the followings are fabricated: i) diffraction gratings with tuneable diffraction efficiencies (10–78% diffraction efficiencies), ii) organic electrochemical transistors with a low drive voltage, and iii) embedded electrodes in confined spaces for potential diagnostic applications.

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Fabrication of fillable microparticles and other complex 3D microstructures

Cited by 168 publications

References 30 publications

E‐Skin Tactile Sensor Matrix Pixelated by Position‐Registered Conductive Microparticles Creating Pressure‐Sensitive Selectors

E‐Skin Tactile Sensor Matrix Pixelated by Position‐Registered Conductive Microparticles Creating Pressure‐Sensitive Selectors

Engineering DNA vaccines against infectious diseases

Density Modulation of Embedded Nanoparticles via Spatial, Temporal, and Chemical Control Elements

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