Fabrication of Fe3O4-silica core-shell magnetic nano-particles and its characterization for biomedical applications

Chellappa, M.; Vijayalakshmi, U.

doi:10.1016/j.matpr.2019.02.166

Cited by 21 publications

(10 citation statements)

References 12 publications

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“…Moreover, there are several nanoparticle aggregates with dimensions in the range of 200 nm corresponding to the Fe 3 O 4 @SiO 2 _SW sample. By contrast to other studies investigating the formation of Fe 3 O 4 @SiO 2 core–shell nanoparticles which report considerably larger core sizes and shell thicknesses [ 45 , 55 , 56 ], these results demonstrate the formation of nanoscaled core–shell systems with high uniformity and reduced sizes.…”

Section: Resultscontrasting

confidence: 99%

Iron Oxide–Silica Core–Shell Nanoparticles Functionalized with Essential Oils for Antimicrobial Therapies

et al. 2021

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Recent years have witnessed a tremendous interest in the use of essential oils in biomedical applications due to their intrinsic antimicrobial, antioxidant, and anticancer properties. However, their low aqueous solubility and high volatility compromise their maximum potential, thus requiring the development of efficient supports for their delivery. Hence, this manuscript focuses on developing nanostructured systems based on Fe3O4@SiO2 core–shell nanoparticles and three different types of essential oils, i.e., thyme, rosemary, and basil, to overcome these limitations. Specifically, this work represents a comparative study between co-precipitation and microwave-assisted hydrothermal methods for the synthesis of Fe3O4@SiO2 core–shell nanoparticles. All magnetic samples were characterized by X-ray diffraction (XRD), gas chromatography-mass spectrometry (GC-MS), Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), zeta potential, scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetry and differential scanning calorimetry (TG-DSC), and vibrating sample magnetometry (VSM) to study the impact of the synthesis method on the nanoparticle formation and properties, in terms of crystallinity, purity, size, morphology, stability, and magnetization. Moreover, the antimicrobial properties of the synthesized nanocomposites were assessed through in vitro tests on Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. In this manner, this study demonstrated the efficiency of the core–shell nanostructured systems as potential applications in antimicrobial therapies.

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Section: Resultscontrasting

confidence: 99%

Iron Oxide–Silica Core–Shell Nanoparticles Functionalized with Essential Oils for Antimicrobial Therapies

et al. 2021

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“…The silica shell can be synthesized by several methods, the most used being sol-gel and microemulsion [5]. The sol-gel method, first described by Ströber et al, offers the advantage of obtaining materials of high purity and homogeneity at low costs [5,7,8] and allows the control of shell thickness by adjusting the ratio of ammonium hydroxide concentration to tetraethyl orthosilicate (TEOS) [1]. The sol-gel method involves the use of an alkoxy precursor, the most widely used being TEOS as the main agent for the silica shell build-up, in the presence of a basic catalyst (ammonium hydroxide) [4].…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Sol–Gel Preparation of the Nanostructured Magnetic System for Solid-Phase Synthesis

et al. 2021

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This work describes a new synthesis method for core–shell magnetite nanoparticles with a secondary silica shell, functionalized with a linker system (Fe3O4-PABA-SiO2-linker) using a microwave-assisted heating technique. The functionalized solid nanomaterial was used for the nanophase synthesis of peptides (Fmoc route) as a solid support. The co-precipitation method was selected to obtain magnetite nanoparticles and sol–gel technique for silica coating using a microwave-assisted (MW) procedure. The magnetic properties of the nanoparticle core offer the advantage of a quick and easy alternative for the magnetic separation of the product from the reaction mixture, facilitating all the intermediary washing and separation operations. The intermediate and final materials were analyzed by advanced characterization methods. The effectiveness of the nanophase peptide synthesis using this nanostructured material as solid support was demonstrated for a short peptide sequence.

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“…All spectra were obtained in KBr pellet. The spectra obtained for Fe 3 O 4 and Fe 3 O 4 @SiO 2 are comparable with the IR spectra described previously . Fe 3 O 4 @SiO 2 EDTA nanoparticles were brown, the spectrum is of high quality, is not ragged, and the characteristic signals are present in the spectrum (Figure .…”

Section: Resultsmentioning

confidence: 99%

Comparison of Cadmium Cd²⁺ and Lead Pb²⁺ Binding by Fe₂O₃@SiO₂‐EDTA Nanoparticles – Binding Stability and Kinetic Studies

et al. 2019

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This study describes the synthesis and characterization of ethylenediaminetetraacetic acid (EDTA) functionalized magnetic nanoparticles of 20 nm in size – Fe3O4@SiO2‐EDTA – which were used as a novel magnetic adsorbent for Cd(II) and Pb(II) binding in aqueous medium. These nanoparticles were obtained in two‐stage synthesis: covering by tetraethyl orthosilicate and functionalization with EDTA derivatives. Nanoparticles were characterized using TEM, FT‐IR, and XPS methods. Metal ions were detected under optimized experimental conditions using Differential Pulse Anodic Stripping Voltammetry (DPASV) and Hanging Mercury Drop Electrode (HDME) techniques. We compared the ability of Fe3O4@SiO2‐EDTA to bind cadmium and lead in concentration of 553.9 μg L−1 and 647.5 μg L−1, respectively. Obtained results show that the adsorption rate of cadmium binding was very high. The equilibrium for Fe3O4@SiO2‐EDTA‐Cd(II) was reached within 19 min while for the Fe3O4@SiO2‐EDTA‐Pb(II) was reached within 25 minutes. About 2 mg of nanoparticles was enough to bind 87.5 % Cd(II) and 54.1 % Pb(II) content. In the next step the binding capacity of Fe3O4@SiO2‐EDTA nanoparticles was determined. Only 1.265 mg of Fe3O4@SiO2‐EDTA was enough to bind 96.14 % cadmium ions while 5.080 mg of nanoparticles bound 40.83 % lead ions. This phenomenon proves that the studied nanoparticles bind Cd(II) much better than Pb(II). The cadmium ions binding capacity of Fe3O4@SiO2‐EDTA nanoparticles decreased during storage in 0.5 M KCl solution. Two days of Fe3O4@SiO2‐EDTA storage in KCl solution caused the 32 % increase in the amount of nanoparticles required to bind 60 % of cadmium while eight‐days storage caused further increase to 328 %. The performed experiment confirmed that the storage of nanoparticles in solution without any surfactants reduced their binding capacity. The best binding capacity was observed for the nanoparticles prepared directly before the electrochemical measurements.

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Fabrication of Fe3O4-silica core-shell magnetic nano-particles and its characterization for biomedical applications

Cited by 21 publications

References 12 publications

Iron Oxide–Silica Core–Shell Nanoparticles Functionalized with Essential Oils for Antimicrobial Therapies

Iron Oxide–Silica Core–Shell Nanoparticles Functionalized with Essential Oils for Antimicrobial Therapies

Microwave-Assisted Sol–Gel Preparation of the Nanostructured Magnetic System for Solid-Phase Synthesis

Comparison of Cadmium Cd²⁺ and Lead Pb²⁺ Binding by Fe₂O₃@SiO₂‐EDTA Nanoparticles – Binding Stability and Kinetic Studies

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Fabrication of Fe3O4-silica core-shell magnetic nano-particles and its characterization for biomedical applications

Cited by 21 publications

References 12 publications

Iron Oxide–Silica Core–Shell Nanoparticles Functionalized with Essential Oils for Antimicrobial Therapies

Iron Oxide–Silica Core–Shell Nanoparticles Functionalized with Essential Oils for Antimicrobial Therapies

Microwave-Assisted Sol–Gel Preparation of the Nanostructured Magnetic System for Solid-Phase Synthesis

Comparison of Cadmium Cd2+ and Lead Pb2+ Binding by Fe2O3@SiO2‐EDTA Nanoparticles – Binding Stability and Kinetic Studies

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Comparison of Cadmium Cd²⁺ and Lead Pb²⁺ Binding by Fe₂O₃@SiO₂‐EDTA Nanoparticles – Binding Stability and Kinetic Studies