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The aim of this research was to develop advanced lipid nanocarriers based on renewable vegetable resources (rice bran oil and raspberry seed oil) that possess self-antioxidative properties, having advantages in terms of minimal side effects and exhibiting the ability to simultaneously co-encapsulate and co-release two active compounds. The focus has been oriented towards developing safe cosmetic formulations with broad-spectrum photoprotection based on these new lipid nanocarriers that contain large amounts of vegetable oils and low concentrations of synthetic UVA and UVB filters (butyl-methoxydibenzoylmethane - BMDBM and octocrylene - OCT). The lipid nanocarriers have a spherical shape and show good physical stability, with a zeta potential in the range of -25.5 to -32.4 mV. Both vegetable oils play a key role in the preparation of efficient nanocarriers, leading to a less ordered arrangement of the lipid core that offers many spaces for the entrapment of large amounts of BMDBM (79%) and OCT (90%), as wells as improved antioxidant activity and UV absorption properties, particularly for the lipid nanocarriers prepared from rice bran oil. By formulating the lipid nanocarriers into creams containing only 3.5% of the UV filters and 10.5% of the vegetable oils, the resulting sunscreens exhibited improved photoprotection, reflecting up to 91% and 93% of UVA and UVB rays, respectively. A new direction of research achieved by this study is the multiple release strategy of both UV filters from the same lipid nanocarrier. After 24 hours, a slow release of BMDBM (less than 4%) and OCT (17.5%) was obtained through a Fick diffusion process. This study demonstrates a significant advance in the areas of both nanotechnology and cosmetics, developing safer cosmetic formulations that possess broad antioxidant, photoprotective and co-release effectiveness due to the existence of a high content of nanostructured vegetable oils combined with a low amount of synthetic UV filters in the same carrier system.

Due to their unique features, most nanostructured lipid carriers (NLCs) in association with vegetable oils that exhibit UV filtering properties and bioactivity could be used in many cosmetic formulations. Therefore, in this work, a new application of pomegranate seed oil (PSO) in the cosmetic sector was developed, based on the synthesis of bioactive lipid nanocarriers loaded with various UV filters by the hot high pressure homogenization technique. To get broad spectrum photoprotection, different UVA and UVB filters have been used (Avobenzone — AVO, Octocrylen-OCT, Bemotrizinol — BEMT). The influence of the solid lipids combined with PSO on the particle size, physical stability and entrapment efficiency was investigated using 8 nanocarrier systems. An improved physical stability and an appropriate size were obtained for NLCs prepared with Emulgade, carnauba wax and PSO (e.g. −30.9÷-36.9 mV and 160÷185 nm). NLCs showed an entrapment efficiency above 90% and assured slow release rates of UV filters, especially for BEMT (5%). The developed nanocarriers have been formulated into safe and effective sunscreens containing low amounts of synthetic UV filters coupled with a high percent of natural ingredients. The highest SPF of 34.3 was obtained for a cream comprising of 11% PSO and 3.7% BEMT

In this work, new stable and efficiently bio-active lipid nanocarriers (NLCs) with antioxidant properties have been developed for the transport of active ingredients in food. The novel NLCs loaded with β-sitosterol/β-sitosterol and green tea extract (GTE) and prepared by a combination of natural oils (grape seed oil, fish oil and squalene) and biological lipids with food grade surfactants, were physico-chemically examined by DLS, TEM, electrokinetic potential, DSC and HPLC and found to have main diameters less than 200 nm, a spherical morphology, excellent physical stability, an imperfect crystalline lattice and high entrapment efficiency. The novel loaded-NLCs have demonstrated the potential to develop a high blocking action of chain reactions, trapping up to 92% of the free-oxygen radicals, as compared to the native β-sitosterol (AA%=36.5). Another advantage of this study is associated with the quality of bio-active NLCs based on grape seed oil and squalene to manifest a better sitosterol-sustained release behaviour as compared to their related nanoemulsions. By coupling both in vitro results, i.e. the enhanced antioxidant activity and superior release properties, this study emphasizes the sustainability of novel bio-active nanocarriers to gain specific bio-food features for development of functional foods with a high applicability spectrum.

Triglyceride‐based monomers represent a competitive alternative to petrochemical resources in the macromolecular compounds area. In the current study, several types of hydrophilic camelina oil (CO)‐based monomers were synthesized using tunable experimental protocols that involve three different steps: first—conversion of the double bonds into epoxy rings, second—partial opening of the epoxy rings and methacrylic groups grafting and last—opening of the unreacted epoxy rings and hydrophilic units attaching. 1H‐NMR, 13C‐NMR and FTIR spectroscopy demonstrate the success of the CO functionalization with polymerizable and hydrophilic moieties—polyethylene glycol units—with different molecular weights, exhibiting self‐emulsifiable properties. Several bulk and emulsion polymerization tests were performed for the synthesized monomers and their ability to build polymer networks using different photo‐chemical procedures (using visible and UV radiations respectively) was demonstrated, without additional surfactants. FTIR spectroscopy indicates the polymerization success by the disappearance of the specific bands assigned to the double bonds from methacrylic groups and thermogravimetric analysis demonstrates that the emulsion polymerization leads to materials with an improved thermostability.