Fabrication of Electrospun Polylactic Acid/Cinnamaldehyde/β-Cyclodextrin Fibers as an Antimicrobial Wound Dressing

Liu, Yaowen; Liang, Xue; Zhang, Rong; Lan, Wenting; Qin, Wen

doi:10.3390/polym9100464

Cited by 66 publications

(59 citation statements)

References 45 publications

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“…Although, silver (Ag) nanoparticles have been blended into electrospun zein fibers to achieve antibacterial properties, [ 25 ] it is believed that use of natural medicinal extracts such as essential oils can further boost pharmaceutical applications and in vivo patient care due to their low toxicity and broad spectrum antimicrobial activities. [ 26–32 ]…”

Section: Introductionmentioning

confidence: 99%

In Situ Electrospinning Wound Healing Films Composed of Zein and Clove Essential Oil

Qin

Mou

Dong

et al. 2020

Macro Materials & Eng

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Electrospun fibrous membranes have the potential to be effective wound dressings for promoting wound healing. However, the fabrication and application of the common electrospun fibrous wound dressings are usually complicated and separated. Here, electrospun zein/clove essential oil (CEO) fibrous membranes are fabricated and applied as a potential wound dressing through in situ electrospinning process by a portable electrospinning device. The in situ electrospinning process can directly electrospin zein/CEO membranes onto a wound site to cover the wound well and improve the convenience and comfort in use. The as‐spun zein/CEO membranes show a porous structure and exhibit higher gas permeability at 168.2 ± 43.3 mm s−1, with superhydrophilicity to absorb the wound exudate and good biocompatibility as well as antibacterial effects to protect from infection. Moreover, the mice wound model study suggests that in situ electrospun zein/CEO promotes the wound healing process.

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Section: Introductionmentioning

confidence: 99%

In Situ Electrospinning Wound Healing Films Composed of Zein and Clove Essential Oil

Qin

Mou

Dong

et al. 2020

Macro Materials & Eng

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“…33 However, cinnamaldehyde has certain shelf-life problems due to its high volatility, low stability, low solubility, and sensitivity to oxygen, light, and heat. 34,35 Yet, molecular encapsulation of cinnamaldehyde with cyclodextrin inclusion complexation is one of the promising approaches in order to eliminate the abovementioned drawbacks of cinnamaldehyde. For example, it was shown that enhancement of photostability and thermostability of cinnamaldehyde after complexation with γ-CD derivatives was possible.…”

Section: ■ Introductionmentioning

confidence: 99%

“…35,40,41 For instance, cinnamaldehyde/β-CD-ICincorporated polylactic acid (PLA) nanofibrous mat was fabricated as a potential candidate for the use of wound dressing material due to its antibacterial properties and low cytotoxicity. 35 Also, a polyvinyl alcohol/cinnamon essential oil/β-CD-IC nanofibrous film was fabricated by electrospinning for active food packaging by increasing the hightemperature stability of cinnamon essential oil by inclusion complexation and prolonging the shelf life of strawberries by showing effective antimicrobial activity. 40 Also, cinnamon essential oil/β-CD-IC was incorporated into electrospun PLA NFs for antimicrobial packaging application in which the PLA/ cinnamon essential oil/β-CD nanofibrous film has shown better antimicrobial activity compared to PLA/cinnamon essential oil nanofibrous film.…”

Section: ■ Introductionmentioning

confidence: 99%

Molecular Encapsulation of Cinnamaldehyde within Cyclodextrin Inclusion Complex Electrospun Nanofibers: Fast-Dissolution, Enhanced Water Solubility, High Temperature Stability, and Antibacterial Activity of Cinnamaldehyde

Yıldız

Kılıç

Durgun

et al. 2019

J. Agric. Food Chem.

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The electrospinning of nanofibers (NFs) of cinnamaldehyde inclusion complexes (ICs) with two different hydroxypropylated cyclodextrins (CDs), hydroxypropyl-β-cyclodextrin (HP-β-CD) and hydroxypropyl-γ-cyclodextrin (HP-γ-CD), was successfully performed in order to produce cinnamaldehyde/CD-IC NFs without using an additional polymer matrix. The inclusion complexation between cinnamaldehyde and hydroxypropylated CDs was studied by computational molecular modeling, and the results suggested that HP-β-CD and HP-γ-CD can be inclusion complexed with cinnamaldehyde at 1:1 and 2:1 (cinnamaldehyde/CD) molar ratios. Additionally, molecular modeling and phase solubility studies showed that water solubility of cinnamaldehyde dramatically increases with cyclodextrin inclusion complex (CD-IC) formation. The HP-β-CD has shown slightly stronger binding with cinnamaldehyde when compared to HP-γ-CD for cinnamaldehyde/CD-IC. Although cinnamaldehyde is a highly volatile compound, it was effectively preserved with high loading by the cinnamaldehyde/CD-IC NFs. It was also observed that cinnamaldehyde has shown much higher temperature stability in cinnamaldehyde/CD-IC NFs compared to uncomplexed cinnamaldehyde because of the inclusion complexation state of cinnamaldehyde within the hydroxypropylated CD cavity. Moreover, cinnamaldehyde still has kept its antibacterial activity in cinnamaldehyde/CD-IC NF samples when tested against Escherichia coli. In addition, cinnamaldehyde/CD-IC NF mats were fast-dissolving in water, even though pure cinnamaldehyde has a water-insoluble nature. In brief, self-standing nanofibrous mats of electrospun cinnamaldehyde/CD-IC NFs are potentially applicable in food, oral-care, healthcare, and pharmaceutics because of their fast-dissolving character, enhanced water solubility, stability at elevated temperature, and promising antibacterial activity.

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“…Biocompatible materials play a more and more important role in tissue engineering [9], medicine delivery [10], antibacterial application [11], and wound healing [12]. Among them, synthetic polymer materials are very popular in the skin regeneration [13,14]. As one of the synthetic polymers, Poly-l-lactic acid (PLLA) with controlled degradation has been studied in clinic medicine for a long time [15].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Core–Shell Fibrous 2D Scaffold with Biocompatible Poly(Glycerol Sebacate) and Poly-l-Lactic Acid for Wound Healing

Yang

et al. 2020

Adv. Fiber Mater.

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Biomimetic scaffolds made by synthetic materials are usually used to replace the natural tissues aimed at speeding up the skin regeneration. In this study, a flexible and cytocompatible poly(glycerol sebacate)@poly-l-lactic acid (PGS@PLLA) fibrous scaffold with a core-shell structure was fabricated by coaxial electrospinning, where the shell PLLA was used to be a skeleton with pores on the fibrous surface. The fibrous morphology with pores on the surface of the prepared fibers was observed by SEM. The core-shell microstructure of PGS@PLLA fibers was confirmed by TEM and Laser Scanning Confocal Microscopy (LSCM). In addition, the prepared fibers exhibited a strong ability to repair tissues of the skin wound, where the stability of cell security and proliferation, and the lower inflammatory response were all superior to those of pure PLLA scaffold. It's worth noting that the percentage of skin tissue was regenerated by 95% within 14 days, which suggests the potential application for electrospun-based synthetic fibrous scaffolds on wound healing.

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Fabrication of Electrospun Polylactic Acid/Cinnamaldehyde/β-Cyclodextrin Fibers as an Antimicrobial Wound Dressing

Cited by 66 publications

References 45 publications

In Situ Electrospinning Wound Healing Films Composed of Zein and Clove Essential Oil

In Situ Electrospinning Wound Healing Films Composed of Zein and Clove Essential Oil

Molecular Encapsulation of Cinnamaldehyde within Cyclodextrin Inclusion Complex Electrospun Nanofibers: Fast-Dissolution, Enhanced Water Solubility, High Temperature Stability, and Antibacterial Activity of Cinnamaldehyde

Electrospun Core–Shell Fibrous 2D Scaffold with Biocompatible Poly(Glycerol Sebacate) and Poly-l-Lactic Acid for Wound Healing

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