Fabrication of drug-loaded edible carrier substrates from nanosuspensions by flexographic printing

Palo, Mirja; Kolakovic, Ruzica; Laaksonen, Timo; Määttänen, Anni; Genina, Natalja; Salonen, Jarno; Peltonen, Jouko; Sandler, Niklas

doi:10.1016/j.ijpharm.2015.01.027

Cited by 20 publications

(14 citation statements)

References 35 publications

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“…Filmy z hydroksypropylometuloceluozą (HPMC) i glicerolem [13,15] Filmy z HPMC [16] Filmy z HPMC, krospowidonu, glicerolu i wody Papier ksero Nieprzepuszczalna dla wody folia przezroczysta [17] Papier cukrowy Filmy z hydroksypropylocelulozy (HPC) Filmy z politereftalanu etylenu (PET) [18] Filmy octanowe Filmy ze skrobi ziemniaczanej [19] podłoże drukowe cylinder formowy…”

Section: Materiał Nośnikowy Piśmiennictwounclassified

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Printing technologies in pharmaceutical compounding as a new perspective for hospital pharmacy

Pyteraf¹,

Jamróz²,

Jachowicz³

2019

Farm Pol.

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Printing technologies in pharmaceutical compounding as a new perspective for hospital pharmacy • The possibility of preparing drugs based on two-and three-dimensional printing technologies have recently been explored in the pharmaceutical field. Possibility of implementation of printing techniques in the preparation of compounded drugs, especially in a hospital pharmacy, was the object of this review. Printing technologies allow production of complex drug products in a single process. Therefore, this technology can become an innovative method preparation of compounded drugs adapted to patients with special therapeutic needs.

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Section: Materiał Nośnikowy Piśmiennictwounclassified

“…wałek rastrowy zespół farbowy cylinder dociskowy leczniczej należą właściwości nanoszonego materiału takie jak: lepkość, napięcie powierzchniowe oraz szybkość parowania [17]. Utwardzenie lepiszcza może zachodzić poprzez odparowanie rozpuszczalnika lub pod wpływem działania promieniowania UV [9].…”

Section: Materiał Nośnikowy Piśmiennictwounclassified

Printing technologies in pharmaceutical compounding as a new perspective for hospital pharmacy

Pyteraf¹,

Jamróz²,

Jachowicz³

2019

Farm Pol.

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“…While several authors focused on the printing of solutions on the films, the application of micro‐ or nanosuspensions is only limited to a few publications. They especially concentrate on the establishment of the technologies and the analysis of, e.g., the dissolution behavior of the APIs but do not analyze the particles sizes after being released from the films.…”

Section: Introductionmentioning

confidence: 99%

Redispersion of Nanoparticle‐Loaded Orodispersible Films: Preservation of Particle Fineness

Steiner

Finke

Kwade

2017

Chemie Ingenieur Technik

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The application of orodispersible films (ODFs) as carrier for drug nanoparticles was discovered a few years ago. Poorly water-soluble drugs are milled to nanosuspensions to improve their bioavailability. During the manufacturing process they are embedded into a polymer matrix or loaded on the surface of drug-free ODF templates. The particle size of the particles released from the ODF was measured when redispersed in water. A preservation of the drug particle sizes could be achieved for both investigated ODF types when an adequate amount of matrix material is added to prevent agglomeration during the drying process.

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“…Several approaches based on the application of polymeric drug “carrier” particulates have been extensively developed and studied such as polymeric nanoparticles (NPs), nanosuspensions, microemulsions, microspheres, and liposomes . Besides them, molecularly imprinted polymers (MIPs) have shown a great promise as a new class of synthesized polymeric materials that are appropriate candidates for controlling drugs in biomedical applications …”

Section: Introductionmentioning

confidence: 99%

Synthesis of poly(2-hydroxyethyl methacrylate)-based molecularly imprinted polymer nanoparticles containing timolol maleate: morphological, thermal, and drug release along with cell biocompatibility studies

Aeinehvand

Zahedi

Kashani-Rahimi

et al. 2016

Polym. Adv. Technol.

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a This work was aimed to synthesize and characterize poly(2-hydroxyethyl methacrylate) [poly (HEMA)]-based molecularly imprinted polymer nanoparticles (MIP NPs) containing timolol maleate (TM) via precipitation polymerization. The molecular structures of the MIP and non-imprinted polymer (NIP) NPs were compared by means of Fourier transform infrared spectroscopy. The morphological observations by using scanning electron microscopy and transmission electron microscopy confirmed the formation of MIP NPs as small as 128 nm in average diameter with appropriate synthesis conditions. Thermal behaviors of the samples were also studied by the use of thermogravimetric analysis and differential scanning calorimetry. By considering a series of key factors such as monomer : template ratio, cross-linker type, pH, and temperature, the sample with promising characteristics was found to be that of HEMA : TM ratio of 10:1, 40 mmol of ethylene glycol dimethacrylate as cross-linker, and polymerization temperature of 60°C in acetonitrile as porogenic solvent. Furthermore, the ultraviolet-visible (UV-vis) spectrophotometry results proved a controlled release of TM from the MIP NP samples compared with NIP ones at extended periods. Moreover, the cytotoxicity of the MIP and NIP NPs samples was evaluated on mesenchymal stem cells, and the obtained observations showed that they had no adverse side effect on the living cells; especially the surface of the MIP NPs sample depicted highly cellˈs biocompatibility. Finally, the outcomes from designed different experiments conducted us that the HEMA-based MIP NPs have great potential as an ocular nanocarrier for TM delivery.

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Fabrication of drug-loaded edible carrier substrates from nanosuspensions by flexographic printing

Cited by 20 publications

References 35 publications

Printing technologies in pharmaceutical compounding as a new perspective for hospital pharmacy

Printing technologies in pharmaceutical compounding as a new perspective for hospital pharmacy

Redispersion of Nanoparticle‐Loaded Orodispersible Films: Preservation of Particle Fineness

Synthesis of poly(2-hydroxyethyl methacrylate)-based molecularly imprinted polymer nanoparticles containing timolol maleate: morphological, thermal, and drug release along with cell biocompatibility studies

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