Fabrication of dicalcium phosphate dihydrate-coated β-TCP granules and evaluation of their osteoconductivity using experimental rats

Shariff, Khairul Anuar; Tsuru, Kanji; Ishikawa, Kunio

doi:10.1016/j.msec.2017.03.004

Cited by 30 publications

(28 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some researcher reported that larger amounts of DCPD‐forming cements caused a certain degree of tissue inflammation during early phase of in vivo implantation . On the contrary, it was recently reported that 5 wt % DCPD‐coated β‐TCP (DCPD/β‐TCP) granules show higher osteoconductivity than pure β‐TCP granules even though osteoconductivity of 15 wt % DCPD/β‐TCP was lower than 5 wt % DCPD/β‐TCP . Although detailed mechanism of the improved osteoconductivity of DCPD/β‐TCP granules has not been clarified, release of Ca 2+ and PO 4 3– ions are thought to be the key.…”

Section: Discussionmentioning

confidence: 99%

“…17,18 On the contrary, it was recently reported that 5 wt % DCPD-coated b-TCP (DCPD/b-TCP) granules show higher osteoconductivity than pure b-TCP granules even though osteoconductivity of 15 wt % DCPD/b-TCP was lower than 5 wt % DCPD/b-TCP. 19 Although detailed mechanism of the improved osteoconductivity of DCPD/b-TCP granules has not been clarified, release of Ca 21 and PO 4 3ions are thought to be the key. Dissolution of DCPD not only release Ca 21 and PO 4 3ions but also H 1 and decrease the pH.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Fabrication of self‐setting β‐tricalcium phosphate granular cement

et al. 2017

Self Cite

View full text Add to dashboard Cite

Bone defect reconstruction would be greatly improved if β-tricalcium phosphate (β-TCP) granules had the ability to self-set without sacrificing their osteoconductivity potential. This study aimed to identify a method to permit β-TCP self-setting whilst maintaining good osteoconductivity. When mixed with acidic calcium phosphate solution, β-TCP granules were found to readily set, forming a fully interconnected porous structure. On mixing, dicalcium phosphate dihydrate crystals formed on the surface of β-TCP granules, bridging the granules and resulting in the setting reaction. The setting time of the β-TCP granular cement (β-TCP GC) was approximately 1 min and its mechanical strength, in terms of diametral tensile strength, was approximately 0.8 MPa. The β-TCP GC and β-TCP granules both showed the same level of osteoconductivity within rat calvaria bone defects. At 2 and 4 weeks post-implantation, new bone formation was comparable between the two β-TCP based bone substitutes. We conclude that β-TCP GC has excellent potential for use as a cement in bone defect reconstruction. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 800-807, 2018.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fabrication of self‐setting β‐tricalcium phosphate granular cement

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several studies demonstrated greater ability to form new bone after being implanted in the body. 24 − 26 …”

Section: Introductionmentioning

confidence: 99%

Biomaterial Property Effects on Platelets and Macrophages: An in Vitro Study

Fernandes

Zhang

Magri

et al. 2017

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

The purpose of this study was to evaluate the effects of surface properties of bone implants coated with hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) on platelets and macrophages upon implant installation and compare them to grit-blasted Ti and Thermanox used as a control. Surface properties were characterized using scanning electron microscopy, profilometry, crystallography, Fourier transform infrared spectroscopy, and coating stability. For platelets, platelet adherence and morphology were assessed. For macrophages, morphology, proliferation, and polarization were evaluated. Surface characterization showed similar roughness of ∼2.5 μm for grit-blasted Ti discs, both with and without coating. Coating stability assessment showed substantial dissolution of HA and β-TCP coatings. Platelet adherence was significantly higher for grit-blasted Ti, Ti-HA, and Ti-β-TCP coatings compared to that of cell culture control Thermanox. Macrophage cultures revealed a decreased proliferation on both HA and β-TCP coated discs compared to both Thermanox and grit-blasted Ti. In contrast, secretion of pro-inflammatory cytokine TNF-α and anti-inflammatory cytokine TGF-β were marginal for grit-blasted Ti and Thermanox, while a coating-dependent increased secretion of pro- and anti-inflammatory cytokines was observed for HA and β-TCP coatings. The results demonstrated a significantly upregulated pro-inflammatory and anti-inflammatory cytokine secretion and marker gene expression of macrophages on HA and β-TCP coatings. Furthermore, HA induced an earlier M1 macrophage polarization but more M2 phenotype potency than β-TCP. In conclusion, our data showed that material surface affects the behaviors of first cell types attached to implants. Due to the demonstrated crucial roles of platelets and macrophages in bone healing and implant integration, this information will greatly aid the design of metallic implants for a higher rate of success in patients.

show abstract

“…Of course, the immune system of an individual patient is very important for the response to implanting biomaterials [12]. Bioglasses and other bioceramics such as calcium phosphates bond to natural bone and support the proliferation of new cells [2,[13][14][15]. Surface wettability enhances osteoblast adhesion of human cells and also cell proliferation [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Sol-Gel Derived Calcium Hydroxyapatite Coatings Fabricated on Patterned Rough Stainless Steel Surface

et al. 2019

Self Cite

View full text Add to dashboard Cite

Sol-gel derived calcium hydroxyapatite (Ca10(PO4)6(OH)2; CHA) thin films were deposited on stainless steel substrates with transverse and longitudinal patterned roughness employing a spin-coating technique. Each layer in the preparation of CHA multilayers was separately annealed at 850 °C in air. Fabricated CHA coatings were placed in simulated body fluid (SBF) for 2, 3, and 4 weeks and investigated after withdrawal. For the evaluation of obtained and treated with SBF coatings, diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), X-ray diffraction (XRD) analysis, Raman spectroscopy, XPS spectroscopy, scanning electron microscopy (SEM) analysis, and contact angle measurements were used. The tribological properties of the CHA coatings were also investigated in this study.

show abstract

Fabrication of dicalcium phosphate dihydrate-coated β-TCP granules and evaluation of their osteoconductivity using experimental rats

Cited by 30 publications

References 37 publications

Fabrication of self‐setting β‐tricalcium phosphate granular cement

Fabrication of self‐setting β‐tricalcium phosphate granular cement

Biomaterial Property Effects on Platelets and Macrophages: An in Vitro Study

Characterization of Sol-Gel Derived Calcium Hydroxyapatite Coatings Fabricated on Patterned Rough Stainless Steel Surface

Contact Info

Product

Resources

About