Fabrication of dense biocompatible hydroxyapatite ceramics with high hardness using a peroxide-based route: a potential process for scaling up

Randorn, Chamnan; Kanta, Acharapun; Yaemsunthorn, Kasidid; Rujijanakul, Gobwute

doi:10.1016/j.ceramint.2014.12.139

Cited by 18 publications

(9 citation statements)

References 27 publications

(31 reference statements)

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“…This may be due to the complex interaction of the implant surface with the biological environment into which it was inserted. Hydroxyapatite dissolution and reprecipitation can occur along the bone implant interface [25]. The presence of a phosphate peak at 960 cm −1 within the Raman spectrum supports the possibilities (Figure 4) related to the presence of bone formation.…”

Section: Discussionsupporting

confidence: 59%

Mechanical and Spectroscopic Analysis of Retrieved/Failed Dental Implants

Daood

Banday²,

Akram

et al. 2017

Coatings

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Abstract:The purpose of this study was to examine surface alterations and bone formation on the surface of failed dental implants (Straumann [ST] and TiUnite [TiUn]) removed due to any biological reason. In addition, failure analysis was performed to test mechanical properties. Dental implants (n = 38) from two manufacturers were collected and subjected to chemical cleaning. The presence of newly formed hydroxyapatite bone around failed implants was evaluated using micro-Raman spectroscopy. Scanning electron microscopy was used to identify surface defects. Mechanical testing was performed using a Minneapolis servo-hydraulic system (MTS) along with indentation using a universal testing machine and average values were recorded. A statistical analysis of mechanical properties was done using an unpaired t test, and correlation between observed defects was evaluated using Chi-square (p = 0.05). Apatite-formation was evident in both implants, but was found qualitatively more in the ST group. No significant difference was found in indentation between the two groups (p > 0.05). The percentage of "no defects" was significantly lower in the ST group (71%). Crack-like and full-crack defects were observed in 49% and 39% of TiUn. The ST group showed 11,061 cycles to failure as compared with 10,021 cycles in the TiUnite group. Implant failure mechanisms are complex with a combination of mechanical and biological reasons and these factors are variable with different implant systems.

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Section: Discussionsupporting

confidence: 59%

Mechanical and Spectroscopic Analysis of Retrieved/Failed Dental Implants

Daood

Banday²,

Akram

et al. 2017

Coatings

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“…Among a variety of bioceramic scaffold materials that have been investigated, hydroxyapatite (HA) [4][5][6], β-tricalcium phosphate (β-TCP) [7,8] and biphasic calcium phosphate (BCP) [9,10] which is a mixture of HA and β-TCP, have attracted much attention for hard tissue engineering owing to their high chemical and structural similarity with natural bone or dentin tissue materials. According to the previous studies, HA is of great biocompatibility and favorable osteogenic potential because of its most similarity to the mineral part of bone and dentin [11,12], but it is characterized with poor biodegradability [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…The morphological and chemical properties of the raw materials and porous BCP bioceramic scaffolds are investigated, the cytological characteristics of the scaffolds are also measured. 5 6 added into the reaction system to keep the pH value constant at 10.0. The suspension was then stirred for another 4 h, during which the pH value was kept by the continually adding of NH 3 H 2 O.…”

Section: Introductionmentioning

confidence: 99%

Fabrication, characterization and cellular biocompatibility of porous biphasic calcium phosphate bioceramic scaffolds with different pore sizes

Tang

Mao

Liu

et al. 2016

Ceramics International

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“…Recently, many researchers have synthesized the biphasic calcium phosphate by various techniques, such as a mechanical blending of the desired amounts of HA and β-TCP, hydrothermal method, vacuum-assisted foaming as well as several other approaches [12][13][14]. In this work, the investigation of BCP synthesized by hot pressing process with the HA powder prepared using a peroxide-based route (PBR) was conducted [13][14][15]. Biomineralization of apatite layer after immersion in simulated body fluid (SBF) was observed.…”

Section: Introductionmentioning

confidence: 99%

Microstructure-property relations of biphasic calcium phosphate obtained by hot pressing process

Kulpetchdara

Limpichaipanit

Randorn

et al. 2019

PAC

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Biphasic calcium phosphate (BCP) was fabricated through hot pressing process from hydroxyapatite (HA) starting powder synthesized by a peroxide-based precipitation method and dried at 250°C. The synthesized HA powder contained some calcium hydrogen phosphate (CHP) as a minor phase. In this work, the dense BCP ceramics with a mixture of HA and β-TCP phases were successfully obtained by hot pressing at temperature ranging from 700-1100°C. The amount of HA phase in the hot pressed samples decreased with increasing sintering temperature from 700 to 900°C, while the amount of β-TCP exhibited an opposite trend. The relations between the microstructure and mechanical properties of the dense BCP ceramics sintered in the temperature range 700-1100°C were investigated. The sample hot pressed at 800°C has a dense structure with the highest hardness (4.86 ± 0.19 GPa) and the lowest fracture toughness (0.80 ± 0.01 MPa•m 1/2). In addition, biocompatibility of apatite layer formed after immersion in simulated body fluid (SBF) for 14 days can be observed by SEM images. The results revealed that the samples hot-pressed at 800 and 900°C were covered by calcium phosphate (CaP) crystal layer indicating the strong interaction of BCP ceramics and SBF.

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Fabrication of dense biocompatible hydroxyapatite ceramics with high hardness using a peroxide-based route: a potential process for scaling up

Cited by 18 publications

References 27 publications

Mechanical and Spectroscopic Analysis of Retrieved/Failed Dental Implants

Mechanical and Spectroscopic Analysis of Retrieved/Failed Dental Implants

Fabrication, characterization and cellular biocompatibility of porous biphasic calcium phosphate bioceramic scaffolds with different pore sizes

Microstructure-property relations of biphasic calcium phosphate obtained by hot pressing process

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