Fabrication of core-shell structured nanofibers of poly (lactic acid) and poly (vinyl alcohol) by coaxial electrospinning for tissue engineering

Alharbi, Hamad F.; Luqman, Monis; Khalil, Khalil Abdelrazek; Elnakady, Yasser A.; Abd‐Elkader, Omar H.; Rady, Ahmed; Alharthi, Nabeel H.; Karim, Mohammad Rezaul

doi:10.1016/j.eurpolymj.2017.11.052

Cited by 68 publications

(55 citation statements)

References 40 publications

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“…PLA/PVA core-shell composite scaffolds increased cell attachment and improved cell growth of human embryonic kidney cells HEK-293. The new co-axial PLA/PVA scaffolds revealed great potential as candidates for biomedical applications, particularly for kidney regeneration [171].…”

Section: Other Applicationsmentioning

confidence: 99%

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

2019

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Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dimensional organization similar to the extracellular matrix. Various polymers can be electrospun in the form of three-dimensional scaffolds. However, very few are successfully processed using environmentally friendly solvents; poly(vinyl alcohol) (PVA) is one of those. PVA has been investigated for TE scaffolding production due to its excellent biocompatibility, biodegradability, chemo-thermal stability, mechanical performance and, most importantly, because of its ability to be dissolved in aqueous solutions. Here, a complete overview of the applications and recent advances in PVA-based electrospun nanofibrous scaffolds fabrication is provided. The most important achievements in bone, cartilage, skin, vascular, neural and corneal biomedicine, using PVA as a base substrate, are highlighted. Additionally, general concepts concerning the electrospinning technique, the stability of PVA when processed, and crosslinking alternatives to glutaraldehyde are as well reviewed.

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Section: Other Applicationsmentioning

confidence: 99%

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

2019

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“…The detailed optimized electrospinning parameters were summarized in Table 1 . When applying an air‐blowing rate of 30 L min –1 , and a voltage of 28 kV, the total flow rate for electrospinning could reach to 2.5 mL h –1 , which is already much higher than some normal coaxial electrospinning process without air‐blowing‐assistance, such as PLA‐PVA (0.3 mL h –1 ), TPU‐PS (0.84 mL h –1 ), and PVP‐PAN (1.0 mL h –1 ) . With the same air blowing rate of 30 mL min –1 , but increasing the voltage to 38 kV, the total flow rate for PAN‐TPU coaxial electrospinning could be up to 5.0 mL h –1 , which is already higher than the largest value of 4 mL h –1 for normal coaxial electrospinning of PEG‐PBS system .…”

Section: Resultsmentioning

confidence: 97%

Air‐Blowing‐Assisted Coaxial Electrospinning toward High Productivity of Core/Sheath and Hollow Fibers

Duan

Greiner

2019

Macro Materials & Eng

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Coaxial electrospinning is an attractive technology to produce core/sheath and hollow fibers. However, until now, the relatively low productivity has limited its broad applications. In this work, coaxial electrospinning with air‐blowing‐assistance is applied to improve the productivity of core/sheath and hollow fibers. Different core and shell materials are used for this electrospinning. The flow rate and air‐blowing rate during electrospinning are optimized. SEM and TEM are used to confirm the core/sheath and hollow structure of fibers. The results show that air‐blowing‐assisted electrospinning technology can be successfully applied for the large‐scale production of core/sheath and hollow fibers which open the path to new applications of this promising class of materials.

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“…The nanofibers produced so far have applications in many disciplines of engineering and medical sciences. The basics of nanofiber spinning of biopolymers have been described by Jamil et al [7]; Pham et al [8]; Vasita and katti et al [9]; Kriegel et al [10]; Shekh et al [11]; Tuerdimaimaiti et al [12]; Amariei et al [13]; Yoon et al [14]; Alharbi et al [15]; Chen et al [16].…”

Section: Introductionmentioning

confidence: 99%

Electrospinning process parameters optimization for biofunctional curcumin/gelatin nanofibers

Kanu

Gupta

Vates

et al. 2020

Mater. Res. Express

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Electrospinning has received wide attention for the preparation of uniform diameter nanofibers (ranging from 5 nm to several hundred nanometers) in films with random as well as aligned fashions of the fibers of various materials for use in biomedical applications. Electrospinning research has provided an in-depth understanding of the preparation of light weight, ultrathin, porous, biofunctional curcumin/gelatin nanofibers having applications in wound dressing, drug release, tissue engineering, etc. In the first half of this article, prior research on electrospun curcumin/gelatin nanofibers is reviewed in depth with nanofibers being desired due to their low diameters since these would have then large surface area to volume ratio and enough film porosity as well as improved mechanical (tensile) strength so that when prepared as mats these nanofibers (having high biocompatibility) could be used for sustained release of curcumin and oxygen to wounds during healing. The synthesis of ultrathin nanofibers (having minimum average diameter) is not a simple task unless numerical investigation is carefully done in the first half of this research article. The authors research described here examined the effects of critical process parameters (in the second half of the paper) such as distance between the spinneret and collector, flow rate, voltage and solution viscosity, on the preparation of uniform and ultrathin nanofibers using scanning electron microscopy (SEM) for characterization of the nanofibers. A 2 k factorial design of experiment was found to be a suitable and efficient technique to optimize the critical process parameters used in the preparation of the biofunctional nanofibers with the purpose of having applications in the treatment of problematic wounds such as diabetic chronic ulcers. After parametric investigation, the distance, flow rate and voltage when taken together, were found to have the most significant contributions to the preparation of minimum diameter nanofibers. The primary objective of this research was fulfilled with the development of ultrathin curcumin/gelatin nanofibers having a 181 nm (181±66 nm) average diameter using the optimized setting of a solution having 1.5% gelatin, and 1% curcumin in 10 ml of 98% concentrated formic acid, with the electrospining unit having a voltage of 10 KV, distance from the spinneret to collector drum of 15 cm, flow rate of 0.1 ml h −1 , viscosity of 65 cP and drum collector speed of 1000 rpm. However, the lowest average diameter of nanofiber was measured around 147 nm (147±34 nm) which was prepared at a higher voltage, such as 15 KV (at 10 cm distance, 0.15 ml h −1 flow rate and 65 cP viscosity) using the solution. The design of this research paper is based on the view that merely optimization of biofunctional nanofibers may not fully satisfy researchers/ engineers unless they are also provided with sufficient information about (a) the entire electrospinning mechanism (numerical investigations of the mechanism) to have better control over preparation of ultr...

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Fabrication of core-shell structured nanofibers of poly (lactic acid) and poly (vinyl alcohol) by coaxial electrospinning for tissue engineering

Cited by 68 publications

References 40 publications

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

Air‐Blowing‐Assisted Coaxial Electrospinning toward High Productivity of Core/Sheath and Hollow Fibers

Electrospinning process parameters optimization for biofunctional curcumin/gelatin nanofibers

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