Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing

Goyanes, Álvaro; Chang, Hanah; Sedough, Daniel; Hatton, Grace B.; Wang, Jie; Buanz, Asma; Gaisford, Simon; Basit, Abdul W.

doi:10.1016/j.ijpharm.2015.10.039

Cited by 282 publications

(161 citation statements)

References 26 publications

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“…14) There are several early reports of PVA-based tablets, [15][16][17][18][19] but it remains unclear how the printing conditions used with an FDM 3D-type printer affects the formability of the printed tablets. We designed tablets under different conditions using 3D computer-aided-design (CAD) software and set different 3D printing conditions by using slicer software.…”

Section: Abstract Three-dimensional (3d) Printing; Fused Depositionmentioning

confidence: 99%

3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets

Tagami

Fukushige

Ogawa

et al. 2017

Biological & Pharmaceutical Bulletin

114

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Three-dimensional (3D) printers have been applied in many fields, including engineering and the medical sciences. In the pharmaceutical field, approval of the first 3D-printed tablet by the U.S. Food and Drug Administration in 2015 has attracted interest in the manufacture of tablets and drugs by 3D printing techniques as a means of delivering tailor-made drugs in the future. In current study, polyvinylalcohol (PVA)-based tablets were prepared using a fused-deposition-modeling-type 3D printer and the effect of 3D printing conditions on tablet production was investigated. Curcumin, a model drug/fluorescent marker, was loaded into PVA-filament. We found that several printing parameters, such as the rate of extruding PVA (flow rate), can affect the formability of the resulting PVA-tablets. The 3D-printing temperature is controlled by heating the print nozzle and was shown to affect the color of the tablets and their curcumin content. PVA-based infilled tablets with different densities were prepared by changing the fill density as a printing parameter. Tablets with lower fill density floated in an aqueous solution and their curcumin content tended to dissolve faster. These findings will be useful in developing drug-loaded PVA-based 3D objects and other polymerbased articles prepared using fused-deposition-modeling-type 3D printers. Key words three-dimensional (3D) printing; fused deposition modeling; polyvinylalcohol (PVA); tablet; curcuminThe production of various objects by three-dimensional (3D) printers has developed extensively as the printers have evolved.1,2) 3D printers are used by the creator to rapidly design prototype parts and can thus considerably cut production times and costs. 3D printers have been used to manufacture parts for cars, home electronic devices, aircraft engines, buildings, and for other practical uses. It is speculated that 3D printers have potential for many applications and that the 3D printer market will expand.The medical applications of 3D printers have been expanding and bringing innovation to the field.3) For example, the 3D printing of organs and body parts is used to provide blueprints 4) for surgeons and patients to understand disease sites.5-7) In addition, bioprinting, which involves the placement of cells, proteins and genes on a substrate, is also being conducted in the anticipation of future applications in tissue engineering.8,9) Future artificial organs and implantable devices are also being designed. 10,11) In the pharmaceutical industry, a new tablet (SPRITAM ® , a rapid disintegrating tablet containing levetiracetam) prepared by 3D printing was approved by the U.S. Food and Drug Administration (FDA) in 2015.12) The application of 3D printing in medicine, including tablets, holds promise for made-to-order drugs and removes mass product manufacturing from the production line, although the technology in pharmaceutical industry is still in infancy.13) Moreover, it is predicted that the internet of things (IoT) will increase the future use of 3D printers by reinforcing man...

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Section: Abstract Three-dimensional (3d) Printing; Fused Depositionmentioning

confidence: 99%

3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets

Tagami

Fukushige

Ogawa

et al. 2017

Biological & Pharmaceutical Bulletin

114

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“…43 In fact, poly(vinyl) alcohol has been used as a drug carrier for aminosalicylate modified-release tablets, 44 prednisolone extendedrelease tablets, 45 and budesonide modified-release tablets. 46 On the other hand, ethyl vinyl acetate has been used as a novel drug carrier for a 3D printed T-shaped intrauterine drug delivery system for indomethacin. 47 In a similar study, polycaprolactone has also been used to deliver indomethacin in a controlled-release manner in a 3D printed polycaprolactone-based implantable prototype of Tshaped intrauterine system.…”

Section: Limitationsmentioning

confidence: 99%

Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

Lim

Chia

Kang

et al. 2016

Journal of Pharmaceutical Sciences

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“…The potential of FDM 3D printers has been explored in the incorporation of different API molecules through their loading into commercially available PVA filaments (7)(8)(9). These previous attempts, however, displayed several limitations such as the use of non-pharmaceutical grade ingredients and limited drug loading (9,10). Previous reports suggested the need for using high temperatures [220 o C (8), 210 o C (9) and 250 o C (7)] when PVA based dosage forms were fabricated using FDM 3D printers.…”

Section: Introductionmentioning

confidence: 99%

A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets

et al. 2016

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2 ABSTRACTPurpose. The fabrication of a ready-to-use immediate release tablets via 3D printing provides a powerful tool to on-demand individualization of dosage form. This work aims to adapt a widely used pharmaceutical grade polymer, polyvinylpyrrolidone (PVP), for instant on-demand production of immediate release tablets via FDM 3D printing.Methods. Dipyridamole or theophylline loaded filaments were produced via processing a physical mixture of API (10%) and PVP in the presence of plasticizer through hot-melt extrusion (HME). Computer software was utilized to design a capletshaped tablet. The surface morphology of the printed tablet was assessed using scanning electron microscopy (SEM). The physical form of drug and its integrity following an FDM 3D printing were assessed using x-ray powder diffractometry (XRPD), thermal analysis and HPLC. In vitro drug release studies for all 3D printed tablets were conducted in a USP II dissolution apparatus.Results. Bridging 3D printing process with HME in the presence of a thermostable filler, talc, enabled the fabrication immediate release tablets at temperatures as low as 110 o C. The integrity of two models drugs was maintained following HME and FDM 3D printing. XRPD indicated that a portion of the loaded theophylline remained crystalline in the tablet. The fabricated tablets demonstrated excellent mechanical properties, acceptable in-batch variability and an immediate in vitro release pattern. Conclusions.Combining the advantages of PVP as an impeding polymer with FDM 3D printing at low temperatures, this approach holds a potential in expanding the spectrum of drugs that could be used in FDM 3D printing for on demand manufacturing of individualised dosage forms.

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Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing

Cited by 282 publications

References 26 publications

3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets

3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets

Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets

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