Fabrication of Concentrated Palm Olein-Based Diacylglycerol Oil–Soybean Oil Blend Oil-In-Water Emulsion: In-Depth Study of the Rheological Properties and Storage Stability

Ng, Siou Pei; Khor, Yih Phing; Lim, Hong Kwong; Lai, Oi Ming; Wang, Yong; Wang, Yonghua; Cheong, Ling‐Zhi; Nehdi, Imededdine Arbi; Mansour, Lamjed; Tan, Chin Ping

doi:10.3390/foods9070877

Cited by 15 publications

(17 citation statements)

References 36 publications

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“…This could influence the release rate of drug, owing to the time needed for the formulation to recover its viscosity and initial structure, when the imposed shear rate decreases. Thus, active substances incorporated in more thixotropic systems have more time to be released faster in the period of low viscosity caused by the spreading of the emulsion over the skin [ 50 ]. However, and as previously referred, these differences should fade when the FF is produced at an industrial scale.…”

Section: Resultsmentioning

confidence: 99%

Complying with the Guideline for Quality and Equivalence for Topical Semisolid Products: The Case of Clotrimazole Cream

et al. 2021

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Semisolids constitute a significant proportion of topical pharmaceutical dosage forms available on the market, with creams being considered profitable systems for releasing active substances into the skin. This work aimed at the development of a generic Clotrimazole topical cream, based on the assumptions that assist the development of such formulations. First, the critical parameters to obtain a final formulation as similar as possible to the reference product were defined. Then, the percentages of cetyl palmitate and octyldodecanol were identified as critical variables and chosen for optimization in further studies. A “quality by design” approach was then used to identify the effect of process variability on the structural and functional similarity (Q3) of the generic product qualitatively (Q1) and quantitatively (Q2). A two-factor central composite orthogonal design was applied and eleven different formulations were developed and subjected to physicochemical characterization and product performance studies. The results were used to estimate the influence of the two variables in the variation of the responses, and to determine the optimum point of the tested factors, using a design space approach. Finally, an optimized formulation was obtained and analysed in parallel with the reference. The obtained results agreed with the prediction of the chemometric analysis, validating the reliability of the developed multivariate models. The in vitro release and permeation results were similar for the reference and the generic formulations, supporting the importance of interplaying microstructure properties with product performance and stability. Lastly, based on quality targets and response constraints, optimal working conditions were successfully achieved.

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Section: Resultsmentioning

confidence: 99%

Complying with the Guideline for Quality and Equivalence for Topical Semisolid Products: The Case of Clotrimazole Cream

et al. 2021

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“…These color parameters were analyzed and are shown in Table 2 . The lightness value (L) is often determined by the scattering effect, while the redness (a) and yellowness (b) are dependent on absorption [ 36 ]. Unlike the FSEY group, the control group and TBHQ groups showed a significant reduction in their lightness values (L).…”

Section: Resultsmentioning

confidence: 99%

“…Unlike the FSEY group, the control group and TBHQ groups showed a significant reduction in their lightness values (L). The changes from bright white to grey indicate a decrease in the L value, and an increase in the particle size distribution, owing to the reduced light scattering effect [ 36 ]. Here, the decrease in the L values of the control group corresponded to the increase in particle size, which is in good agreement with the particle size analysis and those analyses reported by others [ 36 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…The changes from bright white to grey indicate a decrease in the L value, and an increase in the particle size distribution, owing to the reduced light scattering effect [ 36 ]. Here, the decrease in the L values of the control group corresponded to the increase in particle size, which is in good agreement with the particle size analysis and those analyses reported by others [ 36 , 37 ]. Although the L values in the TBHQ group significantly decreased, we did not find an increase in particle size via the laser particle size analyzer and LSCM.…”

Section: Resultsmentioning

confidence: 99%

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Impact of Tetrapeptide-FSEY on Oxidative and Physical Stability of Hazelnut Oil-In-Water Emulsion

Shi

Liu

et al. 2021

Foods

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This study investigates the antioxidant behaviors of a hazelnut tetrapeptide, FSEY (Phe-Ser-Glu-Tyr), in an oil-in-water emulsion. The emulsion was prepared with stripped hazelnut oil at a ratio of 10%. O/W emulsions, both with and without antioxidants (FSEY and TBHQ), were incubated at 37 °C. The chemical stabilities, including those of free radicals and primary and secondary oxidation productions, along with the physical stabilities, which include particle size, zeta-potential, color, pH, and ΔBS, were analyzed. Consequently, FSEY displayed excellent antioxidant behaviors in the test system by scavenging free lipid radicals. Both primary and secondary oxidation products were significantly lower in the FSEY groups. Furthermore, FSEY assisted in stabilizing the physical structure of the emulsion. This antioxidant could inhibit the increase in particle size, prevent the formation of creaming, and stabilize the original color and pH of the emulsion. Consequently, FSEY may be an effective antioxidant additive to use in emulsion systems.

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“…All tests were carried out in triplicate at 25℃ using a circulating bath and a controlled Peltier system. The collected rheological data were fitted using the Ostwald de Waele and Herschel-Bulkley models (Ng et al, 2020) to characterize the rheological behavior of the SIO emulsions..…”

Section: Rheological Measurementsmentioning

confidence: 99%

Production of Sacha Inchi oil emulsions by high‐shear and high‐intensity ultrasound emulsification: Physical properties and stability

González-Cardozo

Mora-Huertas

Gutiérrez

2021

J. Food Process. Preserv.

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Sacha Inchi (Plukenetia volubilis L.) is a plant of the Euphorbiaceae family with a great economic expansion in Central and South America, as well as in some South-East Asiatic countries (Gutiérrez et al., 2019).This promising crop has potential industrial applications in foods, pharmaceuticals, and cosmetics, since their fruits (shell-covered kernels) are a good source of oil (35%-60%) rich in polyunsaturated fatty acids and tocopherols (Gutiérrez et al., 2017). The main fatty acids of Sacha Inchi oil (SIO) are α-linolenic (47%-51%) and linoleic (34%-37%) (Gutiérrez et al., 2011). The most abundant tocopherols in SIO are γ-and δ-tocopherol, ranging from 50 to 114 and from 30 to 125 mg per 100 g, respectively (Gutiérrez et al., 2017). SIO is generally consumed as dressing for salads or as a food supplement. However, to harness the wide range of health benefits of the essential fatty acids, for example, to avoiding cognitive impairment,

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Fabrication of Concentrated Palm Olein-Based Diacylglycerol Oil–Soybean Oil Blend Oil-In-Water Emulsion: In-Depth Study of the Rheological Properties and Storage Stability

Cited by 15 publications

References 36 publications

Complying with the Guideline for Quality and Equivalence for Topical Semisolid Products: The Case of Clotrimazole Cream

Complying with the Guideline for Quality and Equivalence for Topical Semisolid Products: The Case of Clotrimazole Cream

Impact of Tetrapeptide-FSEY on Oxidative and Physical Stability of Hazelnut Oil-In-Water Emulsion

Production of Sacha Inchi oil emulsions by high‐shear and high‐intensity ultrasound emulsification: Physical properties and stability

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