Fabrication of collagen scaffolds impregnated with sago starch capped silver nanoparticles suitable for biomedical applications and their physicochemical studies

Abstract

The present investigation attempts at fabricating collagen-based scaffolds impregnated with sago starch capped silver nanoparticles (AgNPs), useful for biomedical applications, and aims at studying their physicochemical aspects. AgNPs synthesized through a chemical reduction method, capped using different concentrations of sago starch, are incorporated into collagen derived from fish scales, and lyophilized to form scaffolds. FT-IR spectra confirm and validate the interaction of sago starch capped AgNPs with collagen in the scaffolds. TGA and DSC results indicate enhanced thermal stability of collagen scaffolds impregnated with sago capped AgNPs compared to collagen alone. All the collagen scaffolds containing sago starch capped AgNPs show high tensile strength values for their use as wound dressing materials. Moreover, lower minimum inhibitory concentration values are obtained for the above capped AgNP collagen scaffolds, which indicate higher antibacterial activities compared to uncapped AgNPs tested against both gram positive and negative bacterial strains. The novelty is that the developed scaffolds are biodegradable and in vitro studies reveal them as biocompatible and suitable for tissue regeneration applications.

Investigation of Anti-MRSA and Anticancer Activity of Eco-Friendly Synthesized Silver Nanoparticles from Palm Dates Extract

“…However, Das et al have demonstrated recently to prevent the formation of Ag + ions using nanotechnology combining with silica and proteins, and thereby reduction of toxicity [15]. It also turns out that metals migration from NPs can be easily stopped by coating or packing metallic NPs in organic or inorganic matrix like polymers, polyphenols, ceramics or glasses to be utilized for biomedical applications [16][17][18]. Hence, it is crucial and valuable in the field of nanotechnology to produce and develop greener, consistent, low cost, non-toxic and ecofriendly methods for the synthesis of NPs [19,12].…”

Unique properties of silver and copper silica-based nanocomposites as antimicrobial agents

“…20 Other solutions are based on fabrication of nanocomposite coatings or by packing metallic nanoparticles in organic or inorganic matrix like polymer, ceramics or glasses. [21][22][23] It turned out, that combination of water soluble polymer (PEG) and AgNPs of suitable sizes (<100 nm) prepared in form of coatings; [24][25][26][27] or combination of metal nanoparticles with magnetite (Fe 3 O 4 ) NPs improve antibacterial and biomedical properties. 28 However, the most versatile matrices seems to be composed of chemically modied silica.…”

Upconverting nanocomposites dispersed in urea-containing acrylics

“…Urea-containing polymers appear to be particularly promising for applications using silica and metal coated UCNPs, due to the high levels of hydrogen bonding between urea groups with silica and the well-known urea-metal interaction. [20][21][22][23] The ABA triblock copolymer architecture is a well-recognized sequence for the formation of mechanically ductile films and coatings. This architecture is superior to urea-methacrylate homopolymers, since the central low glass transition temperature (T g ) block will provide critical ductility to the film, thus rendering the film to be durable for optical applications.…”