Fabrication of chitosan-polycaprolactone composite nanofibrous scaffold for simultaneous delivery of ferulic acid and resveratrol

Balan, Poornima; Korrapati, Purna Sai

doi:10.1016/j.carbpol.2016.11.056

Cited by 140 publications

(67 citation statements)

References 23 publications

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“…liver, colon, stomach, breast, prostate, lung and tongue), and also to decrease blood glucose levels (meaning it has promise for the treatment of diabetes) [50,51]. FA is poorly soluble, and its sustained release would be useful to improve its absorption and bioavailability [40,52]. The materials reported here provide zero-order drug release profiles, and the release duration and rate can be tuned through the thickness of the CA coating, which can itself be precisely manipulated through the flow rate of the middle fluid in electrospinning.…”

Section: Introductionmentioning

confidence: 99%

Tunable zero-order drug delivery systems created by modified triaxial electrospinning

Liu

Yang

et al. 2019

Chemical Engineering Journal

137

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ucture, and in turn its functional performance, is of crucial importance for potential applications. In this study, a new modified triaxial electrospinning process was successfully developed to allow us to precisely tune drug release from nanoscale formulations. In this process, we used two un-electrospinnable liquids as the outer and middle working fluids, with only the core solution being individually electrospinnable into fibers. The outer liquid comprised a mixture of solvents, while the middle fluid was a dilute solution of cellulose acetate (CA). The core fluid was an electrospinnable co-dissolving solution of ferulic acid (FA) and gliadin. By processing these in triaxial electrospinning, we were able to create FA-gliadin fibers coated with a thin but even and continuous coating of CA. The thickness of the CA coating could be precisely varied by adjusting the flow rate of the middle working fluid. The resultant nanofibers have linear and cylindrical morphologies with clear core-shell structures. X-ray diffraction and IR spectroscopy data verified that the fibers comprised amorphous solid dispersions, with intermolecular interactions existing between FA and gliadin. The CA coating eliminated the initial burst release seen with uncoated FA-gliadin fibers, and also led to close to zero-order release profiles which could be incrementally adjusted by varying the thickness of the coating. New process-nanostructure-performance relationships are therefore revealed, and the advanced triaxial electrospinning approach reported in this work has great potential for developing new kinds of functional nanomaterials.

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Section: Introductionmentioning

confidence: 99%

Tunable zero-order drug delivery systems created by modified triaxial electrospinning

Liu

Yang

et al. 2019

Chemical Engineering Journal

137

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“…FA protects against ultraviolet (UV) radiation and reduces skin hyperpigmentation [18]. The introduction of FA into chitosan-polycaprolactone coreshell nanofibers has supported their efficacy in proangiogenic and anti-inflammatory activities [19]. The complex of FA/cyclodextrin representing high degree of photostability and high association constant has found application in sunscreen delivery systems [20].…”

Section: Introductionmentioning

confidence: 99%

Retinol derivative as bioinitiator in the synthesis of hydroxyl-functionalized polymethacrylates for micellar delivery systems

Odrobińska¹,

Neugebauer²

2019

Express Polym. Lett.

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Amphiphilic copolymers containing 2-hydroxyethyl methacrylate (HEMA) and methyl methacrylate (MMA) units were synthesized by controlled atom transfer radical polymerization (ATRP) applying bromoester modified retinol (RETBr) as a novel initiator. Analogous series of copolymers with adjustable hydrophilic-hydrophobic balance was obtained with the use of a standard initiator, i.e. ethyl α-bromoisobutyrate (EBriB). The self-assembling particles, prepared by the solvent evaporation, were loaded with vitamin C (VitC) or ferulic acid (FA). The hydrophilic/hydrophobic ratio in the copolymer was indicated as a crucial factor to regulate efficiencies of encapsulation processes in the range of 53-98%. In vitro release of bioactive substance was carried out in phosphate buffer solution (PBS) at pH 7.4 with the maximum amount of VitC after 1h (27-62%) or FA within 2 h (71-97%). The polymeric systems with satisfactory encapsulation characteristics and release profiles are attractive micellar carriers of antioxidants, which, due to their activities could be also delivered using the popular approaches in cosmetology like masks, under-eye patches, or wraps.

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“…Polymer nanofibers have been largely used in applications ranging from biomedical applications such as in tissue engineering, regenerative medicine, and anti‐infective membranes to military and food industries. Moreover, they can be used to encapsulate and deliver natural antimicrobial active substances such as essential oils and phytoconstituents to replace synthetic ones, therefore, being of great interest to pharmaceutical and food products …”

Section: Introductionmentioning

confidence: 99%

Polystyrene bioactive nanofibers using orange oil as an ecofriendly solvent

Miranda

Mattoso

Bresolin

et al. 2018

J of Applied Polymer Sci

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Solution blow spun polystyrene (PS) nanofibers were produced from 20 to 30 wt % PS solutions using toluene (industrial solvent) and orange oil (green solvent). The latter being composed of D-limonene (97.06%) as determined by gas chromatography-mass spectroscopy. The rheological behavior and volatility of the solvents and polymer solutions were correlated with fiber morphology, accessed by scanning electron microscopy. Thermal analysis was used to determine the thermal behavior of fibers. The antimicrobial activity of orange oil was tested for potential applications of the spun mats in active food packaging. Results showed that the nanofibers spun from orange oil solutions had average diameters of 306 AE 74 nm as opposed to 441 AE 110 nm for toluene. Moreover, when compared with fiber spun from toluene solutions, orange oil yielded more flexible fibers with slightly lower contact angles and better antimicrobial properties due to the presence of residual oil confirmed by Fourier-transform infrared spectroscopy.

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Fabrication of chitosan-polycaprolactone composite nanofibrous scaffold for simultaneous delivery of ferulic acid and resveratrol

Cited by 140 publications

References 23 publications

Tunable zero-order drug delivery systems created by modified triaxial electrospinning

Tunable zero-order drug delivery systems created by modified triaxial electrospinning

Retinol derivative as bioinitiator in the synthesis of hydroxyl-functionalized polymethacrylates for micellar delivery systems

Polystyrene bioactive nanofibers using orange oil as an ecofriendly solvent

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