Fabrication of cellulosic composite scaffolds for cartilage tissue engineering

Nandgaonkar, Avinav G.; Krause, Wendy E.; Lucia, L. A.

doi:10.1016/b978-1-78242-452-9.00009-1

Cited by 13 publications

(6 citation statements)

References 77 publications

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“…In recent years, cellulose, in particular the specific type of this polymer, namely bacterial cellulose (BC), has been used for the synthesis of various types of advanced composite materials including hydrogel compositions for biomedical applications (Figueiredo et al, 2013, 2015, Lin, Dufresne, 2014, Nandgaonkar et al, 2016, Ullah et al, 2016. Cellulose is a natural polymer characterized by the high mechanical stiffness and excellent biocompatibility (Sannino et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

High-strength cellulose–polyacrylamide hydrogels: Mechanical behavior and structure depending on the type of cellulose

Buyanov

Gofman

Сапрыкина

2019

Journal of the Mechanical Behavior of Biomedical Materials

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Two types of high-strength composite hydrogels possessing the structure of interpenetrating polymer networks were synthesized via free-radical polymerization of acrylamide carried out straight within the matrix of plant or bacterial cellulose swollen in the reactive solution. The mechanical behavior of synthesized hydrogels subjected to the action of compressive deformations with different amplitude values was studied. The analysis of the stress-strain curves of compression tests of the hydrogels of both types obtained in different test conditions demonstrates the substantial difference in their mechanical behavior. Both the plant cellulose-based and bacterial cellulose-based hydrogels withstand successfully the compression with the amplitude up to 80 %, but the bacterial cellulose-based compositions demonstrate in the multiple compression tests the substantial decrease of the mechanical stiffness caused by the action of compressions. This effect takes place straightly during the multiple cyclic compression tests or in the course of relaxation of previously compressed samples in water in unloaded state during 2-3 days after the first compressive tests. Being subjected to the action of the extremely sever compression (up to 80 %) the bacterial cellulose-based hydrogel varies greatly its mechanical behavior: during the subsequent compressions the stiffness of the material keeps extremely small (as compared to that registered in the first compression) up to the deformations as high as 50-60 % with the dramatic increase of the stiffness during the further loading. This unusual effect can be explained by the deep reorganization of the intermolecular structure of the material with the stress-induced reorientation of cellulose micro-fibrils, fragmentation and disintegration of the interpenetrating networks structure with the breaking of the covalent bonds in the matrix polymer. Submicron-and micron-scale specific features of structures of composite hydrogels of both types were studied by cryo-scanning electron microscopy to explain the peculiarities of observed mechanical effects.

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Section: Introductionmentioning

confidence: 99%

High-strength cellulose–polyacrylamide hydrogels: Mechanical behavior and structure depending on the type of cellulose

Buyanov

Gofman

Сапрыкина

2019

Journal of the Mechanical Behavior of Biomedical Materials

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“…Cellulose is a biopolymer used in numerous industrial applications. This biopolymer has several applications (Abitbol et al, 2016;Choo, Ching, Chuah, Sabariah, Liou, 2016;Nandgaonkar, Krause, & Lucia, 2016) as a novel physical and chemical reinforcement in nanocomposite materials (Cao, Dong, & Li, 2007;De France, Chan, Cranston, & Hoare, 2016; because of its high mechanical strength (El Miri et al, 2016;Li, Cao, Cao, Guo, & Lu, 2016;Siqueira, Bras, & Dufresne, 2008), shear assembly and di-electrophoresis behaviour (Csoka, Hoeger, Peralta, Peszlen, & Rojas, 2011). Cellulose is a linear syndiotactic homopolymer composed of danhydroglucopyranose units which are linked by β-(1→4)-glycosidic bonds (Qiu and Hu, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effect of TEMPO-oxidization and rapid cooling on thermo-structural properties of nanocellulose

Haniffa

Ching

Chuah

et al. 2017

Carbohydrate Polymers

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Recently, surface functionality and thermal property of the green nanomaterials have received wide attention in numerous applications. In this study, microcrystalline cellulose (MCC) was used to prepare the nanocrystalline celluloses (NCCs) using acid hydrolysis method. The NCCs was treated with TEMPO [(2,2,6,6-tetramethylpiperidin-1-yl)oxy radical]-oxidation to prepare TEMPO-oxidized NCCs. Cellulose nanofibrils (CNFs) also prepared from MCC using TEMPO-oxidation. The effects of rapid cooling and chemical treatments on the thermo-structural property studies of the prepared nanocelluloses were investigated through FTIR, thermogravimetric analysis-derivative thermogravimetric (TGA-DTG), and XRD. A posteriori knowledge of the FTIR and TGA-DTG analysis revealed that the rapid cooling treatment enhanced the hydrogen bond energy and thermal stability of the TEMPO-oxidized NCC compared to other nanocelluloses. XRD analysis exhibits the effect of rapid cooling on pseudo 2 helical conformation. This was the first investigation performed on the effect of rapid cooling on structural properties of the nanocellulose.

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“…However, only cellulose II is completely biodegradable and appropriate for tissue repair, as it has no crystalline phase [ 24 ]. The interest in this polymer for cartilage TE is based on its chemical similarity to AC collagen fibres [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Cellulose-Based Scaffolds: A Comparative Study for Potential Application in Articular Cartilage

et al. 2023

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Osteoarthritis is a highly prevalent disease worldwide that leads to cartilage loss. Tissue engineering, involving scaffolds, cells, and stimuli, has shown to be a promising strategy for its repair. Thus, this study aims to manufacture and characterise different scaffolds with poly(ε-caprolactone) (PCL) with commercial cellulose (microcrystalline (McC) and methyl cellulose (MC) or cellulose from agro-industrial residues (corncob (CcC)) and at different percentages, 1%, 2%, and 3%. PCL scaffolds were used as a control. Morphologically, the produced scaffolds presented porosities within the desired for cell incorporation (57% to 65%). When submitted to mechanical tests, the incorporation of cellulose affects the compression resistance of the majority of scaffolds. Regarding tensile strength, McC2% showed the highest values. It was proven that all manufactured scaffolds suffered degradation after 7 days of testing because of enzymatic reactions. This degradation may be due to the dissolution of PCL in the organic solvent. Biological tests revealed that PCL, CcC1%, and McC3% are the best materials to combine with human dental pulp stem/stromal cells. Overall, results suggest that cellulose incorporation in PCL scaffolds promotes cellular adhesion/proliferation. Methyl cellulose scaffolds demonstrated some advantageous compressive properties (closer to native cartilaginous tissue) to proceed to further studies for application in cartilage repair.

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Fabrication of cellulosic composite scaffolds for cartilage tissue engineering

Cited by 13 publications

References 77 publications

High-strength cellulose–polyacrylamide hydrogels: Mechanical behavior and structure depending on the type of cellulose

High-strength cellulose–polyacrylamide hydrogels: Mechanical behavior and structure depending on the type of cellulose

Effect of TEMPO-oxidization and rapid cooling on thermo-structural properties of nanocellulose

Cellulose-Based Scaffolds: A Comparative Study for Potential Application in Articular Cartilage

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