Fabrication of cellulose nanocrystals as potential anticancer drug delivery systems for colorectal cancer treatment

Yusefi, Mostafa; Soon, Michiele Lee-Kiun; Teow, Sin-Yeang; Monchouguy, Elaine Irene; Neerooa, Bibi Noorheen Haleema Mooneerah; Jahangirian, Hossein; Rafiee-Moghaddam, Roshanak; Webster, Thomas J.; Shameli, Kamyar

doi:10.1016/j.ijbiomac.2021.12.189

Cited by 28 publications

(13 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a result of their features, NCs in the bloodstream are passively targeted to organs that are rich in mononuclear phagocytic system (MPS) cells, e.g., liver, spleen, and lung. 302,303 Furthermore, NCs can also serve as carriers for smallmolecular drugs if they are used with protein−drug complexes as stabilizers. Xin et al reported an NC-based nanoplatform with dual loading of paclitaxel and marimastat for efficient treatment of metastatic cancer.…”

Section: Inorganic Nddss In Cancer Therapymentioning

confidence: 99%

See 1 more Smart Citation

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Khan

Hossain

et al. 2022

ACS Appl. Bio Mater.

156

View full text Add to dashboard Cite

Traditional treatment approaches for cancer involve intravenous chemotherapy or other forms of drug delivery. These therapeutic measures suffer from several limitations such as nonspecific targeting, poor biodistribution, and buildup of drug resistances. However, significant technological advancements have been made in terms of superior modes of drug delivery over the last few decades. Technical capability in analyzing the molecular mechanisms of tumor biology, nanotechnologyparticularly the development of biocompatible nanoparticles, surface modification techniques, microelectronics, and material scienceshas increased. As a result, a significant number of nanostructured carriers that can deliver drugs to specific cancerous sites with high efficiency have been developed. This particular maneuver that enables the introduction of a therapeutic nanostructured substance in the body by controlling the rate, time, and place is defined as the nanostructured drug delivery system (NDDS). Because of their versatility and ability to incorporate features such as specific targeting, water solubility, stability, biocompatibility, degradability, and ability to reverse drug resistance, they have attracted the interest of the scientific community, in general, and nanotechnologists as well as biomedical scientists. To keep pace with the rapid advancement of nanotechnology, specific technical aspects of the recent NDDSs and their prospects need to be reported coherently. To address these ongoing issues, this review article provides an overview of different NDDSs such as lipids, polymers, and inorganic nanoparticles. In addition, this review also reports the challenges of current NDDSs and points out the prospective research directions of these nanocarriers. From our focused review, we conclude that still now the most advanced and potent field of application for NDDSs is lipid-based, while other significantly potential fields include polymer-based and inorganic NDDSs. However, despite the promises, challenges remain in practical implementations of such NDDSs in terms of dosage and stability, and caution should be exercised regarding biocompatibility of materials. Considering these aspects objectively, this review on NDDSs will be particularly of interest for small-to-large scale industrial researchers and academicians with expertise in drug delivery, cancer research, and nanotechnology.

show abstract

Section: Inorganic Nddss In Cancer Therapymentioning

confidence: 99%

“…NCs have high drug loading capacity, platform stability, ease of scaling up, and good water solubility. As a result of their features, NCs in the bloodstream are passively targeted to organs that are rich in mononuclear phagocytic system (MPS) cells, e.g., liver, spleen, and lung. , …”

Section: Inorganic Nddss In Cancer Therapymentioning

confidence: 99%

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Khan

Hossain

et al. 2022

ACS Appl. Bio Mater.

156

View full text Add to dashboard Cite

show abstract

“…80 There were signs of aggregation and the formation of strong hydrogen bonds between the hydroxyl groups on the surfaces of cellulose chains during the sample preparation and drying procedures. 81 Furthermore, a slight aggregation could be induced across the CNCs by the freeze drying process. 82 According to Vadim G. Kessler et al ., spherically shaped CNCs can be used for carrying drugs with a long-term drug release and the maintenance of antibacterial properties.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of versatile and sustainable cellulose nanocrystals from lettuce stalks as potential tamoxifen delivery vehicles for breast cancer treatment: biophysical, cellular and theoretical studies

Khashkhashi-Moghadam,

Soleimani,

Bazanjani

et al. 2023

New J. Chem.

View full text Add to dashboard Cite

show abstract

“…The whole assembly was maintained on a magnetic stirrer at 600 rpm for a period of 600 min, and samples were withdrawn at an interval of 1 h for 8 h and replaced with an equal volume of buffer. Samples were appropriately diluted with buffer and analysed for the drug (β-sitosterol) using a UV spectrophotometer at 279 nm [ 37 , 38 ].…”

Section: Methodsmentioning

confidence: 99%

Central Composite Design (CCD) for the Optimisation of Ethosomal Gel Formulation of Punica granatum Extract: In Vitro and In Vivo Evaluations

Alam

Shakeel

Foudah

et al. 2022

Gels

View full text Add to dashboard Cite

This research manuscript’s objective was to develop the Punica granatum extract ethosome gel. The use of nanotechnology can improve transdermal drug delivery permeation of its major bioactive compound β-sitosterol. The optimised and developed formulations were further studied in vitro and in vivo. The assessment of the anti-inflammatory activity of the gel was performed in Albino rats. Methanolic extract was prepared and developed into an ethosome suspension and an ethosome gel. To optimise the formulation’s response in terms of particle size (nm) and entrapment efficiency (%), the central composite design (CCD) was used in 22 levels. The effects of factors such as lecithin (%) and ethanol (mL) in nine formulations were observed. Characterisation of ethosome gel was performed and the results showed the particle size (516.4 nm) and mean zeta potential (−45.4 mV). Evaluations of the gel formulation were performed. The results were good in terms of pH (7.1), viscosity (32,158 cps), spreadability (31.55 g cm/s), and no grittiness. In an in vitro study, the percentages of β-sitosterol release of ethosome gel (91.83%), suspension (82.74%), and extracts (68.15%) at 279 nm were recorded. The effects of the formulated gel on formalin-induced oedema in Albino rats showed good results in terms of anti-inflammatory activity. The comparative anti-inflammatory activity of Punica granatum extract and gel showed that the gel action was good for their topical application.

show abstract

Fabrication of cellulose nanocrystals as potential anticancer drug delivery systems for colorectal cancer treatment

Cited by 28 publications

References 45 publications

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Fabrication of versatile and sustainable cellulose nanocrystals from lettuce stalks as potential tamoxifen delivery vehicles for breast cancer treatment: biophysical, cellular and theoretical studies

Central Composite Design (CCD) for the Optimisation of Ethosomal Gel Formulation of Punica granatum Extract: In Vitro and In Vivo Evaluations

Contact Info

Product

Resources

About