Fabrication of carboxymethyl chitosan/poly(ε-caprolactone)/doxorubicin/nickel ferrite core-shell fibers for controlled release of doxorubicin against breast cancer

Abasalta, Mahdi; Asefnejad, Azadeh; Khorasani, Mohammad Taghi; Ramazani, Ahmad

doi:10.1016/j.carbpol.2021.117631

Cited by 55 publications

(38 citation statements)

References 41 publications

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“…A signal at ~1730 cm −1 distinguishes with the Gp crosslinking and, consequently, with a GO addition that can be attributed to νC=O in amide I. Furthermore, the peaks in the range of 1700–1500 cm −1 are linked to amidic vibrations [ 75 ]. The amide II signal is weaker in GCs (1544 cm −1 ) due to the less chemically stable structure and incidental gelatin dissolution and increases with the control material’s crosslinking and compositing, manifesting a blue shift towards 1547 cm −1 [ 76 ].…”

Section: Resultsmentioning

confidence: 99%

Graphene–Oxide Porous Biopolymer Hybrids Enhance In Vitro Osteogenic Differentiation and Promote Ectopic Osteogenesis In Vivo

Șelaru

Herman

Vlăsceanu

et al. 2022

IJMS

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Over the years, natural-based scaffolds have presented impressive results for bone tissue engineering (BTE) application. Further, outstanding interactions have been observed during the interaction of graphene oxide (GO)-reinforced biomaterials with both specific cell cultures and injured bone during in vivo experimental conditions. This research hereby addresses the potential of fish gelatin/chitosan (GCs) hybrids reinforced with GO to support in vitro osteogenic differentiation and, further, to investigate its behavior when implanted ectopically. Standard GCs formulation was referenced against genipin (Gp) crosslinked blend and 0.5 wt.% additivated GO composite (GCsGp/GO 0.5 wt.%). Pre-osteoblasts were put in contact with these composites and induced to differentiate in vitro towards mature osteoblasts for 28 days. Specific bone makers were investigated by qPCR and immunolabeling. Next, CD1 mice models were used to assess de novo osteogenic potential by ectopic implantation in the subcutaneous dorsum pocket of the animals. After 4 weeks, alkaline phosphate (ALP) and calcium deposits together with collagen synthesis were investigated by biochemical analysis and histology, respectively. Further, ex vivo materials were studied after surgery regarding biomineralization and morphological changes by means of qualitative and quantitative methods. Furthermore, X-ray diffraction and Fourier-transform infrared spectroscopy underlined the newly fashioned material structuration by virtue of mineralized extracellular matrix. Specific bone markers determination stressed the osteogenic phenotype of the cells populating the material in vitro and successfully differentiated towards mature bone cells. In vivo results of specific histological staining assays highlighted collagen formation and calcium deposits, which were further validated by micro-CT. It was observed that the addition of 0.5 wt.% GO had an overall significant positive effect on both in vitro differentiation and in vivo bone cell recruitment in the subcutaneous region. These data support the GO bioactivity in osteogenesis mechanisms as being self-sufficient to elevate osteoblast differentiation and bone formation in ectopic sites while lacking the most common osteoinductive agents.

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Section: Resultsmentioning

confidence: 99%

Graphene–Oxide Porous Biopolymer Hybrids Enhance In Vitro Osteogenic Differentiation and Promote Ectopic Osteogenesis In Vivo

Șelaru

Herman

Vlăsceanu

et al. 2022

IJMS

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“…• Doxorubicin drug loaded on carboxymethyl chitosan/poly(ɛ-caprolactone)/ doxorubicin/nickel ferrite core-shell fibers. Here, the Korsmeyer-Peppas model showed the best pharmacokinetic fit [51].…”

Section: Drug Delivery Of Functionalized Nanoferrites For Cancer Treatmentsmentioning

confidence: 83%

“…2. Doxorubicin and nickel ferrite nanoparticles were incorporate into N-carboxymethyl chitosan/poly(ε-caprolactone) nanofibers for drug delivery applications [51].…”

Section: Drugs Loaded On Functionalized Nanoferrites For Cancer Treatmentsmentioning

confidence: 99%

“…Here, the authors used human cancer cell lines as: MCF-7, A-549 [81], A431 [37], SKOV-3, MDA-MB-231 [61], SK-BR3 [33], MDA-MB-231, MCF-10A [90] in a culture media which is incubate in presence of the nanoferrites. Moreover, cytotoxicity determines the efficiency of the formulation [51]. The cytotoxic effect of the nanoformulation tests the cell viability (MTT) assay.…”

Section: Drug Delivery Of Functionalized Nanoferrites For Cancer Treatmentsmentioning

confidence: 99%

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Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

Osorio¹,

Herrera²,

Londoño³

et al. 2021

Ferrites - Synthesis and Applications

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Cancer is the second cause of death worldwide, whose treatment often involves chemotherapy. In a conventional therapy, drug is transported (and usually absorbed) across biological membranes through diffusion and systemic transport. The pathway that medicine must travel before reaching the desired location, can bring adverse or unwanted effects, which are mainly the result of: low bioavailability, low solubility and toxicity. To avoiding risks, nanoparticles coated with the drug could be used as a therapeutic substance to selectively reach an area of interest to act without affecting non-target cells, organs, or tissues (drug delivery). Here, the goal is to enhance the concentration of the chemotherapeutic drug in the disease parts of the body. Among all nanostructured systems, ferrites attract worldwide attention in drug delivery applications. It is due to their versatile magnetic and physicochemical properties. Here, it is reviewed and analyzed recent advances in synthesis, morphology, size, magnetic properties, functionalization with a focus in drug delivery applications of nanoferrites.

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“…The developed composite CS–PCL scaffolds showed a faster degradation rate, more hydrophilicity, and higher thermostability, which could make them a good candidate for biomedical applications [ 24 , 25 ]. Numerous studies have shown that CS–PCL membranes are suitable and promising candidates as vascular grafts, wound dressing for the controlled release of drugs, and carriers of encapsulated enoxaparin [ 26 , 27 , 28 , 29 ]. Furthermore, recent efforts have contributed to mediating the cellular osteogenic growth peptide gene by combining amphiphilic CS, PCL, and bioglass, and gene transfection efficiency was dramatically enhanced in the experimental conditions [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Thermal Stability and Dynamic Mechanical Properties of Poly(ε-caprolactone)/Chitosan Composite Membranes

Zhang

Yang

et al. 2021

Materials

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Poly (ε-caprolactone) (PCL) and chitosan (CS) are widely used as biodegradable and biocompatible polymers with desirable properties for tissue engineering applications. Composite membranes (CS–PCL) with various blend ratios (CS:PCL, w/w) of 0:100, 5:95, 10:90, 15:85, 20:80, and 100:0 were successfully prepared by lyophilization. The thermal stabilities of the CS–PCL membranes were systematically characterized by thermogravimetric analysis (TG), dynamic thermogravimetry (DTG), and differential scanning calorimetry (DSC). It was shown that the blend ratio of PCL and CS had a significant effect on the thermal stability, hydrophilicity, and dynamic mechanical viscoelasticity of the CS–PCL membranes. All the samples in the experimental range exhibited high elasticity at low temperature and high viscosity at high temperatures by dynamic mechanical thermal analysis (DMTA). The performances of the CS–PCL membranes were at optimum levels when the blend ratio (w/w) was 10:90. The glass transition temperature of the CS–PCL membranes increased from 64.8 °C to 76.6 °C compared to that of the pure PCL, and the initial thermal decomposition temperature reached 86.7 °C. The crystallinity and porosity went up to 29.97% and 85.61%, respectively, while the tensile strength and elongation at the breakage were 20.036 MPa and 198.72%, respectively. Therefore, the 10:90 (w/w) blend ratio of CS/PCL is recommended to prepare CS–PCL membranes for tissue engineering applications.

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Fabrication of carboxymethyl chitosan/poly(ε-caprolactone)/doxorubicin/nickel ferrite core-shell fibers for controlled release of doxorubicin against breast cancer

Cited by 55 publications

References 41 publications

Graphene–Oxide Porous Biopolymer Hybrids Enhance In Vitro Osteogenic Differentiation and Promote Ectopic Osteogenesis In Vivo

Graphene–Oxide Porous Biopolymer Hybrids Enhance In Vitro Osteogenic Differentiation and Promote Ectopic Osteogenesis In Vivo

Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

Thermal Stability and Dynamic Mechanical Properties of Poly(ε-caprolactone)/Chitosan Composite Membranes

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