Fabrication of Carbon@Co Nanocages/Nafion/Poly Tiopronin Composite Film and Its Application for Determination of Acetaminophen

This article presents the novel modifier; polyacrylonitrile nanofibers/Ni 0.5 Zn 0.5 Fe 2 O 4 nanoparticles nanoparticles as a novel modifier, which has been synthesized using an electrospinning method. This nanocomposite has been used to construct an electrochemical sensor for highly sensitive determination of sunitinib (STB) drug in biological samples. The synthesized nanocomposite was fully characterized using methods such as Fourier transform infrared spectroscopy, scanning electron microscopy, cyclic voltammetry, and electrochemical impedance spectroscopy. For the electrochemical determination of STB, the differential pulse voltammetry signal of the drug electrooxidation on carbon paste electrode modified with the newly developed nanocomposite was investigated. Preliminary experiments showed that the nanocomposite had an electrocatalytic effect on the electrooxidation of STB and a significant improvement in the anodic current of the drug was obtained at +0.66 V. Under the optimum conditions, the analytical figures of merit were extracted and the method was fully validated. A relatively wide dynamic linear range of 0.018-18.77 μ mol L −1 with the detection limit of 0.9 n mol L −1 was obtained. Furthermore, the method was applied for the determination of STB in biological fluid samples such as human serum samples with acceptable recoveries (97-102), satisfactory precision (2-4%RSD) and minimal matrix effects.

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confidence: 99%

Electrochemical Determination of Sunitinib in Biological Samples Using Polyacrylonitrile Nanofibers/Nickel-Zinc-Ferrite Nanocomposite/Carbon Paste Electrode

Yarahmadi¹,

Madrakian²,

Afkhami³

et al. 2019

“…However, many researches revealed that it could lead to serious hepatotoxicity and acute liver failure (ALF) with overdose. [4][5][6] For adults, the dosing of acetaminophen by mouth should be no more than 2g every day, and for children, the dosing should be reduced according to weight. Therefore, the assay of acetaminophen with high sensitivity and selectivity is highly required, and simple methodologies is also significant for the study of its metabolism and determination its content in biological fluids.…”

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confidence: 99%

Sensitive Detection of Acetaminophen Based on N, P-Co-Doped Carbon Microspheres Modified Electrode

Li¹,

Li²,

Zeng³

et al. 2019

Heteroatom doped carbon materials have attracted intense attention in constructing electrochemical sensors because of their outstanding electrocatalytic performance. Up to now, most of the researches were focused on the electrochemical application of single heteroatom doped carbon microspheres. In this work, N, P-co-doped carbon microspheres (NP-CMs) modified electrode was developed as highly sensitive electrochemical sensor for acetaminophen. NP-CMs were acquired by the calcination of products from the one-pot reaction of dopamine and 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO). Experimental results revealed that NP-CMs showed better electrocatalytic performance compared with N-doped carbon microspheres. Under the optimal conditions, the response of NP-CMs/GCE showed a linear relationship with acetaminophen concentration from 0.07 μM to 30 μM, the linear equation was Y = 0.01356X+0.7417 and the detection limit was 40 nM (S/N = 3). The recoveries of the NP-CMs modified GCE for the assay of acetaminophen in human serum samples were from 94.0% to 106.0%. It was believed that N, P-co-doped carbon microspheres have a great potential in the design of novel pharmaceutical analysis methods.

“…Thanks to its superiorities of high sensitivity, fast response, rapid detection process and low operating cost as compared with other technologies, 5 electrochemical tool has been regarded as promising. Various materials including functionalized carbon materials, 6,7 nanocarbons-loaded metal nanoparticles, 4,8,9 metal oxide 10 or gold composites 11 have been intensively applied in the analysis of AC. Unfortunately, these modified electrodes 3,7,11 are less sensitive owing to their weak conductivity or poor contact during processing.…”

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confidence: 99%

“…In particular, the as-constructed sensor gives rise to an ultra-high sensitivity (102.05 μA μM −1 cm −2 ) and record-low detection limit (3.0 nM) for AC sensing among previously reported sensors. 2,4,6,7,[9][10][11][30][31][32] And it also manifests higher sensitivity for AC even in the presence of ascorbic acid (AA) and dopamine (DA), indicating its excellent selectivity. Simultaneously, the values determined in pharmaceutical sample with NWNC/GCE are highly coincident with the AC standard curve.…”

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confidence: 99%

Ultrahigh Sensitivity Acetaminophen Sensor Based on Network-Structured Nanocarbons

Wang¹,

Cui²,

Zhong³

et al. 2018

Here, we fabricate an ultrasensitive acetaminophen (AC) sensor by using networked nanocarbons (NWNC) derived from hierarchical porous polypyrrole (PPy) hydrogel precursor. Benefiting from the interconnected porous framework and high electron conductivity of this N, P co-doped NWNC, the as-constructed sensor shows record-high sensitivity (102.05 μA μM −1 cm −2 ) and ultra-low detection limit (3.0 nM), which represents a performance progress in AC sensing. Furthermore, the sensor displays excellent selectivity, reproducibility and stability, exhibiting a great perspective in ultrasensitive monitoring of AC in clinical application.