Electrochemical Determination of Sunitinib in Biological Samples Using Polyacrylonitrile Nanofibers/Nickel-Zinc-Ferrite Nanocomposite/Carbon Paste Electrode

Abstract

This article presents the novel modifier; polyacrylonitrile nanofibers/Ni 0.5 Zn 0.5 Fe 2 O 4 nanoparticles nanoparticles as a novel modifier, which has been synthesized using an electrospinning method. This nanocomposite has been used to construct an electrochemical sensor for highly sensitive determination of sunitinib (STB) drug in biological samples. The synthesized nanocomposite was fully characterized using methods such as Fourier transform infrared spectroscopy, scanning electron microscopy, cyclic voltammetry, and electrochemical impedance spectroscopy. For the electrochemical determination of STB, the differential pulse voltammetry signal of the drug electrooxidation on carbon paste electrode modified with the newly developed nanocomposite was investigated. Preliminary experiments showed that the nanocomposite had an electrocatalytic effect on the electrooxidation of STB and a significant improvement in the anodic current of the drug was obtained at +0.66 V. Under the optimum conditions, the analytical figures of merit were extracted and the method was fully validated. A relatively wide dynamic linear range of 0.018-18.77 μ mol L −1 with the detection limit of 0.9 n mol L −1 was obtained. Furthermore, the method was applied for the determination of STB in biological fluid samples such as human serum samples with acceptable recoveries (97-102), satisfactory precision (2-4%RSD) and minimal matrix effects.

Development of Feasible and Economic Electrochemical Sensor Based on Manganese Ferrite Nanoparticles (Mn0.2Fe2.8O4) for Determination of a Platelet Aggregation Inhibitor Ticagrelor Drug in Formulations and Human Blood

“…28 The addition of another metal to magnetite can enhance its electrochemical and adsorptive properties than pure Fe oxides. 29,30 In recent years, ferrite NPs with the general formula of MFe 2 O 4 (M=Fe, Co, Ni, Mn) have attracted great attention of researchers because of their potential applications in biomedicine and industry. 31 Replacing Fe ions in interstitial sites with different metal ions such as Mn, Zn, Ga, Ni, Co or Cu will improve Fe 3 O 4 unique physical z E-mail: hanaa_eldesoky@Science.tanta.edu.eg; mhmubark@Science.tanta.edu.eg properties which originate from electrons hopping between Fe 2+ and Fe 3+ ions.…”

Pretreatment and analysis techniques development of TKIs in biological samples for pharmacokinetic studies and therapeutic drug monitoring

“…Over the past decades, CPEs have become another widely used electrode materials for the fabrication of electrochemical sensors due to their rapid surface renewal, chemical inertness, and low residual current. To enhance analytical performance, various chemical modifications have been applied to CPEs, including Al 2 W 3 O 12 -NPs/CPE [ 124 ], ZnO-NPs/ionic liquid/CPE [ 125 ], CPE modified with MMWCNTs and polyacrylonitrile nanofibers (PAN-NFs) (MMWCNTs/PAN-NFs/CPE) [ 126 ], CPE modified by PAN-NFs and nickel-zinc-ferrite (Ni 0.5 Zn 0.5 Fe 2 O 4 ) (PAN-NFs/Ni 0.5 Zn 0.5 Fe 2 O 4 /CPE) [ 127 ], etc.. Ghapanvari et al. developed Fe 3 O 4 /MWCNTs/PAN-NFs/CPE via bulk modification approach to detect an important anticancer drug imatinib in urine samples ( Fig.…”

Voltammetric responses at modified electrodes and aggregation effects of two anticancer molecules: irinotecan and sunitinib

“…A reported work by Madrakian et al 17 employs carbon paste electrodes modified with a nanocomposite composed of polyacrilonitrile nanofibers and nickel-zinc ferrite nanoparticles for the electrochemical determination of SUN, here we focused our attention on oxides and carbon-based materials; we did not use metals, such as Pt and Au, because in the potential range of analysis their background signals may lead to wrong interpretation of the anticancer molecule responses. 18 In particular, we employed indium tin oxide (ITO), carbon nanotubes (NTs), NT-Nafion composites (NafionNTs) and the conducting polymer poly(3,4-ethylenedioxithiophene) (PEDOT).…”