Voltammetric responses at modified electrodes and aggregation effects of two anticancer molecules: irinotecan and sunitinib

Vercelli, Barbara; Crotti, Sara; Agostini, Marco

doi:10.1039/d0nj03896b

Cited by 5 publications

(3 citation statements)

References 40 publications

(46 reference statements)

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“…The preliminary study of the Cr 6+ reduction current appeared at +0.84 V (vs. Ag) and Cr 3+ reduction at +0.74 V (vs. Ag) (Figure 1). The reduction peak shifts from its standard potential are affected by many factors, including the use of electrodes, electrolytes, and measurement conditions 32 . The potentials for the electrochemical reactions in which are implicated various Cr(VI) species were proposed by the other 33 as the probable mechanism.…”

Section: Resultsmentioning

confidence: 99%

Microdetection of Chromium Mixed–Valences using CuNi/Ti Electrode and Linear Sweep Voltammetry

Syarif

2022

Mediterr.J.Chem.,

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An electrode of non-precious metal has the potency to be utilized as a working electrode for voltammetry measurements of Cr3+ and Cr6+. The analytical performance of the electrode in determining specific metal species qualitatively and quantitatively was studied. The detection data were recorded and analyzed using cyclic voltammetry (CV) and linear sweep voltammetry (LSV), whereas scanning electron microscope (SEM) and X-ray diffraction (XRD) spectroscopy were used to determine the surface morphology and the presence of crystalline in the electrode. Electroanalytical performance was determined by linear sweep voltammetry. The results show that the reduction of Cr6+ to Cr3+ appeared at +0.84 V (vs Ag/AgCl) and the reduction of Cr3+ to Cr2+ at +0.74 V (vs Ag/Ag). The optimum conditions for measuring Cr3+ were found at pH 6, deposition time of 30 seconds, and a scan rate of 160 mVs-1. The optimum pH for measuring Cr6+ is 4, deposition time of 60 seconds, and a scan rate of 140 mVs-1. The regression curve for the Cr3+ is linear in concentration 1 – 10 gL-1 with a correlation coefficient of 0.9883 and a detection limit of 2.08 gL-1. While the Cr6+ is linear in the range of 1 – 10 gL-1 with a correlation coefficient of 0.99 and a detection limit of 2.18 gL-1. There is a slight difference in the individual measurement current and the mixture of Cr3+ and Cr6+ but with a good agreement for the oxidation-reduction potential. The measurement data analysis shows the feasibility of the electrode and the measurement system developed.

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Section: Resultsmentioning

confidence: 99%

Microdetection of Chromium Mixed–Valences using CuNi/Ti Electrode and Linear Sweep Voltammetry

Syarif

2022

Mediterr.J.Chem.,

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“…Vercelli et al. [ 120 ] investigated the responses of sunitinib at modified electrodes using cyclic voltammetry determinations. The peak current values of sunitinib at NafionNT/GCE electrodes were found to be three times higher than those observed at bare GCE electrodes, which could potentially be attributed to the formation of H-aggregates resulting from sunitinib aggregation.…”

Section: Methodsmentioning

confidence: 99%

Pretreatment and analysis techniques development of TKIs in biological samples for pharmacokinetic studies and therapeutic drug monitoring

Chen,

Zhang,

Zhang

et al. 2024

Journal of Pharmaceutical Analysis

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“…The electrochemical analysis is vastly concerned by most scientists in order for its advantages of being quick, simple and economic, and ability to be utilized to recognize on-site searches [ 12 ]. Therefore, electrochemical techniques have been widely utilized in biological [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ] and environmental analysis [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Potent Acrylamide Determination in Food Products Using Ion-Selective Electrode Technique

2021

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A potent selective acrylamide liquid sensor based on the reaction of acrylamide with 2-(5-Bromo-2-pyridylazo)-5-[N-n-Propyl-N-(3-Sulfopropyl) amino] aniline reagent is successfully designed. The characteristics slope (52.33 mV/decade), linearity usable range from 1.0 × 10−7–1.0 × 10−1 molar, limit of detection (1.6 × 10−8) molar, selectivity attitude to several inorganic cations, amino acids and sugars, time of response (8 s), lifetime (four months), pH effect on the electrode potential and the basic validation parameters were studied. The desirable pH applicable range was 3.0–6.5, and the restraint of the developed sensor is independent on this working pH range. The deployed electrode was effectively applied for rapid inexpensive analysis of acrylamide cations in food products with comparison to high-performance liquid chromatographic method and the results were agreeable with each other. The obtained data by the suggested electrode were treated statistically and compared with the various recently published acrylamide sensors.

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Voltammetric responses at modified electrodes and aggregation effects of two anticancer molecules: irinotecan and sunitinib

Abstract: The voltammetric responses of two anticancer molecules Irinotecan (ITC) and Sunitinib (SUN) were investigated at Glassy Carbon (GC) and Indium Tin Oxide (ITO) electrodes bare or modified with carbon nanotubes...

Cited by 5 publications

References 40 publications

Microdetection of Chromium Mixed–Valences using CuNi/Ti Electrode and Linear Sweep Voltammetry

Microdetection of Chromium Mixed–Valences using CuNi/Ti Electrode and Linear Sweep Voltammetry

Pretreatment and analysis techniques development of TKIs in biological samples for pharmacokinetic studies and therapeutic drug monitoring

Potent Acrylamide Determination in Food Products Using Ion-Selective Electrode Technique

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