Fabrication of biocompatible and stimuli-responsive hybrid microgels with magnetic properties via aqueous precipitation polymerization

Medeiros, Sebastião Freitas de; Filizzola, João O.C.; Oliveira, P. M. S.; Silva, Taline M.; Lara, Bárbara R.; Lopes, Milene V.; Rossi-Bergmann, Bartira; Elaı̈ssari, Abdelhamid; Santos, Amilton M.

doi:10.1016/j.matlet.2016.04.004

Cited by 23 publications

(15 citation statements)

References 12 publications

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“…These studies focused on synthesis, structure characterization, and stimuli-controlled responsivity with or without the consideration of model drug release effectiveness. 113,114 The studies include investigations of temperature-responsive volume phase transition 84,88 and subsequent magnetic heating, 91 pH-sensitivity with or without temperature-induced transition 89 and with static-field guidance, 90,92,115 and magnetization response to an applied static field. 93,95 For example, it has been reported that magnetite ( 85,125 In particular, Sunderland et al 126 130 or by employing other magnetic materials and polymers.…”

Section: Part Ii: Biomedical Applications and Translational Technologiesmentioning

confidence: 99%

Magnetic microgels and nanogels: Physical mechanisms and biomedical applications

Sung

Kim

Abelmann

2020

Bioengineering & Transla Med

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Soft micro-and nanostructures have been extensively developed for biomedical applications. The main focus has been on multifunctional composite materials that combine the advantages of hydrogels and colloidal particles. Magnetic microgels and nanogels can be realized by hybridizing stimuli-sensitive gels and magnetic nanoparticles. They are of particular interest since they can be controlled in a wide range of biological environments by using magnetic fields. In this review, we elucidate physical principles underlying the design of magnetic microgels and nanogels for biomedical applications. Particularly, this article provides a comprehensive and conceptual overview on the correlative structural design and physical functionality of the magnetic gel systems under the concept of colloidal biodevices. To this end, we begin with an overview of physicochemical mechanisms related to stimuli-responsive hydrogels and transport phenomena and summarize the magnetic properties of inorganic nanoparticles. On the basis of the engineering principles, we categorize and summarize recent advances in magnetic hybrid microgels and nanogels, with emphasis on the biomedical applications of these materials. Potential applications of these hybrid microgels and nanogels in anticancer treatment, protein therapeutics, gene therapy, bioseparation, biocatalysis, and regenerative medicine are highlighted. Finally, current challenges and future opportunities in the design of smart colloidal biodevices are discussed.

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Section: Part Ii: Biomedical Applications and Translational Technologiesmentioning

confidence: 99%

Magnetic microgels and nanogels: Physical mechanisms and biomedical applications

Sung

Kim

Abelmann

2020

Bioengineering & Transla Med

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“…%) into poly(di(ethylene glycol)) methyl ether methacrylate- co -oligo(ethylene glycol) methyl ether methacrylate- co -methacrylic acid) microgels, obtaining thermo-, pH-, and magnetic-responsive microgels. For the same purpose, other authors used different polymers for the production of the microgels, such as P(VLC- co -IA) based microgels [144], poly(2-(2-methoxyethoxy) ethyl methacrylate- co -oligo(ethylene glycol) methacrylate- co -AAc) incorporated with attapulgite/Fe 3 O 4 NPs [145,146], among others.…”

Section: Multi-stimuli-responsive Hybrid Microgelsmentioning

confidence: 99%

Functional Stimuli-Responsive Gels: Hydrogels and Microgels

Echeverría

Fernandes

Godinho

et al. 2018

Gels

160

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One strategy that has gained much attention in the last decades is the understanding and further mimicking of structures and behaviours found in nature, as inspiration to develop materials with additional functionalities. This review presents recent advances in stimuli-responsive gels with emphasis on functional hydrogels and microgels. The first part of the review highlights the high impact of stimuli-responsive hydrogels in materials science. From macro to micro scale, the review also collects the most recent studies on the preparation of hybrid polymeric microgels composed of a nanoparticle (able to respond to external stimuli), encapsulated or grown into a stimuli-responsive matrix (microgel). This combination gave rise to interesting multi-responsive functional microgels and paved a new path for the preparation of multi-stimuli “smart” systems. Finally, special attention is focused on a new generation of functional stimuli-responsive polymer hydrogels able to self-shape (shape-memory) and/or self-repair. This last functionality could be considered as the closing loop for smart polymeric gels.

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“…In recent years, increasing attention has been paid to microgels that can be operated remotely by using magnetic field or light stimuli . The magnetic properties of these microgels provide us the possibility to guide them to the specific area by using the external magnetic field resulting into targeted drug delivery with reduced toxicity . In this regard, magnetic nanoparticle–loaded thermoresponsive microgels are of particular interest as the temperature change generated by applying an external alternating current magnetic field can lead to remote controlled drug release without the need of any additional stimuli .…”

Section: Microgels For Drug Delivery Applicationmentioning

confidence: 99%

“…Medeiros et al developed temperature‐, pH‐, and magnetic field–responsive PVCL‐ co ‐itaconic acid microgels containing iron oxide nanoparticles via precipitation polymerization . The system was biocompatible and showed potential to be used as a carrier for different drug ingredients which can be further detected by magnetic resonance imaging.…”

Section: Microgels For Imaging Applicationmentioning

confidence: 99%

Functional Microgels: Recent Advances in Their Biomedical Applications

Agrawal

2018

Small

119

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Here, a spotlight is shown on aqueous microgel particles which exhibit a great potential for various biomedical applications such as drug delivery, cell imaging, and tissue engineering. Herein, different synthetic methods to develop microgels with desirable functionality and properties along with degradable strategies to ensure their renal clearance are briefly presented. A special focus is given on the ability of microgels to respond to various stimuli such as temperature, pH, redox potential, magnetic field, light, etc., which helps not only to adjust their physical and chemical properties, and degradability on demand, but also the release of encapsulated bioactive molecules and thus making them suitable for drug delivery. Furthermore, recent developments in using the functional microgels for cell imaging and tissue regeneration are reviewed. The results reviewed here encourage the development of a new class of microgels which are able to intelligently perform in a complex biological environment. Finally, various challenges and possibilities are discussed in order to achieve their successful clinical use in future.

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Fabrication of biocompatible and stimuli-responsive hybrid microgels with magnetic properties via aqueous precipitation polymerization

Cited by 23 publications

References 12 publications

Magnetic microgels and nanogels: Physical mechanisms and biomedical applications

Magnetic microgels and nanogels: Physical mechanisms and biomedical applications

Functional Stimuli-Responsive Gels: Hydrogels and Microgels

Functional Microgels: Recent Advances in Their Biomedical Applications

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