Fabrication of Bio-friendly Polymer Nanosheets for Biomedical Applications

Abstract

We have developed self-standing bio-friendly nanosheets for biomedical applications. These nanosheets were fabricated by simple processes of spin-coating and a novel peeling technique from the substrate. Centimeter-sized nanosheets have unique properties such as amazingly flexibility and high adhesiveness. They could act as a novel wound dressing instead of conventional suturing in surgery. By contrast, fragmented submillimeter-sized nanosheets could act as aqueous surface modifiers to coat even uneven and irregular surfaces in addition to flat surfaces. In fact, such fragmented nanosheets exhibited a high potential to protect burned skin from bacterial infection and to provide blood compatibility to several surfaces. These nanobiomaterials therefore constitute a promising alternative to conventional therapies and coatings in biomedical fields.

Adhesive and robust multilayered poly(lactic acid) nanosheets for hemostatic dressing in liver injury model

“…Second, Na‐Alg was selected as a sacrificial layer to fabricate multilayered nanosheets. PVA acts as an excellent water‐soluble sacrificial layer to release the PLLA nanosheets from the SiO 2 substrate as reported priviously . Moreover, we have proposed a one‐pot fabrication process that uses multilayering of PVA and PLLA on the substrate to collect a large number of free‐standing PLLA nanosheets .…”

“…PVA acts as an excellent watersoluble sacrificial layer to release the PLLA nanosheets from the SiO 2 substrate as reported priviously. [11][12][13] Moreover, we have proposed a one-pot fabrication process that uses multilayering of PVA and PLLA on the substrate to collect a large number of free-standing PLLA nanosheets. 30,31 This technique seems to be helpful to fabricate multilayered nanosheets, however, the nanosheets fabricated by using only PVA as a sacrificial layer were discretely separated when the PVA was dissolved in water.…”

“…For biomedical applications, we have proposed the use of biocompatible nanosheets composed of polysaccharides, such as sodium alginate and chitosan, generated using a layer‐by‐layer method . Moreover, we have also developed biodegradable nanosheets composed of typical polyester series such as poly( l ‐lactic acid) (PLLA) and their copolymers by using simple fabrication processes consisting of a spin‐coating and a new peeling technique . Such polyesters have been clinically applied as biodegradable sutures and bone screws, and so forth, and they have also been widely investigated as injectable drug carriers .…”

“…[8][9][10] Moreover, we have also developed biodegradable nanosheets composed of typical polyester series such as poly(L-lactic acid) (PLLA) and their copolymers by using simple fabrication processes consisting of a spin-coating and a new peeling technique. [11][12][13] Such polyesters have been clinically applied as biodegradable sutures 14 and bone screws, 15 and so forth, and they have also been widely investigated as injectable drug carriers. 16,17 Therefore, utilization of biodegradable polyesters provides an efficient route to clinical application of nanosheets.…”

Patchwork Coating of Fragmented Ultra-Thin Films and Their Biomedical Applications in Burn Therapy and Antithrombotic Coating

“…( A ) Schematic image of patchwork coating to the PET plates ( obtained from [16] and partially modified, with permission from Trans. Mat.…”