Fabrication of asymmetric nanostarch reinforced Chitosan/PVP membrane and its evaluation as an antibacterial patch for in vivo wound healing application

Poonguzhali, R.; Basha, Sakeenabi; Kumari, V. Sugantha

doi:10.1016/j.ijbiomac.2018.03.092

Cited by 59 publications

(17 citation statements)

References 34 publications

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“…The optimised CS-FeHAp films showed a porosity of 53.6 ± 0.9%. This value is comparable to what reported by Poonguzhali et al [41], although in other studies chitosan-based films showed higher porosity [39]. It has to be highlighted, however, that porosity can be affected by many parameters, including chitosan degree of reticulation as well as possible additives added to the matrix [41].…”

Section: Porositysupporting

confidence: 85%

Films of chitosan and natural modified hydroxyapatite as effective UV-protecting, biocompatible and antibacterial wound dressings

Cunha

Castro

Sousa

et al. 2020

International Journal of Biological Macromolecules

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Chitosan is a natural polysaccharide widely used in biomedicine, for instance for wound dressing. Hydroxyapatite is a very bioactive calcium phosphate which, if modified with an appropriate element (iron Fe), can also have UVabsorbing properties. In this work, we report the study of films of chitosan incorporated with iron-modified hydroxyapatite of natural origin (from cod fish bones); this combination led to an innovative chitosan-based material with excellent and advanced functional properties. The films showed very high UV absorption (Ultraviolet Protection Factor (UPF) value higher than 50). This is the first time that a chitosan-based material has shown such high UV protection properties. The films also showed to be non-cytotoxic, and possessed antimicrobial activity towards both Gram-positive and negative strains. Their mechanical properties, optimised with an experimental design approach, confirmed their potential use as multifunctional wound dressing, capable of reducing bacterial infections and, at the same time, protecting from UV light.

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Section: Porositysupporting

confidence: 85%

Films of chitosan and natural modified hydroxyapatite as effective UV-protecting, biocompatible and antibacterial wound dressings

Cunha

Castro

Sousa

et al. 2020

International Journal of Biological Macromolecules

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“…To improve its flexibility, CO and PVP were added. 32,37,38 The results demonstrated that the elongation of the films was then greatly improved. In particular, the PVB/CO/ST had better tensile strength and elongation at break for the same thickness of film and thus was selected for subsequent experiments.…”

Section: Discussionmentioning

confidence: 92%

Silver triethanolamine-loaded PVB/CO films for a potential liquid bandage application

2019

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Many studies have reported that silver has excellent antibacterial properties. However, silver ions can easily react with oxygen to form Ag2O, thus leading to a color change and a reduction in its anti-microbial characteristics. In this study, silver triethanolamine- (ST) loaded PVB/CO solution was prepared as a potential candidate liquid bandage. PVB/CO/ST retained high transparency after exposure to light for 12 months, which allowed convenient inspection of the wound bed without removal of the dressing. The PVB/CO/ST film exhibited favorable properties, such as speed of drying, excellent tensile strength and elongation characteristics and water vapor transmission rate (WVTR). It was comfortable and waterproof, and therefore effective at preventing bacterial invasion, providing effective biosafety. PVB/CO/ST solution-treated wounds exhibited accelerated healing and reduced inflammation in a nude mouse mode. Our data suggested that PVB/CO/ST solution could serve as a promising liquid bandage for treatment of minor trauma.

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“…The injured area was photographed, and its dimension was measured using a digital caliper and Image J software (National Institute of Health, Bethesda, MD) at 0, 2, 5, 7, 10, and 14 days of treatment [ 25 ]. Results were expressed as percentage wound closure relative to the original wound size [ 26 ] using Equation (3), % wound closure = wound area day 0 − wound area day n/wound area day 0 where wound area at day 0 was the original wound area after the surgery and wound area at day n was the wound area on n days of post wounding (day 2, 5, 7, 10, and 14).…”

Section: Methodsmentioning

confidence: 99%

Chitosan Film Containing Mansoa hirsuta Fraction for Wound Healing

et al. 2020

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Chitosan films entrapped with the Mansoa hirsuta fraction (CMHF) was developed as a new dressing for wound care. The chromatographic profile of the M. hirsuta fraction (MHF) was evaluated by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, and the results showed that MHF is rich in acid triterpenes. Physicochemical characterization of the films prepared using the solvent casting method was performed by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetry (TGA), differential scanning calorimetry (DCS), scanning electron microscopy (SEM), atomic force microscopy (AFM), and mechanical properties. CMHF exhibited characteristic bands of both chitosan and MHF, revealing a physical mixture of both. CMHF presented an amorphous nature, thermostability, and dispersion of MHF in the chitosan matrix, resulting in a rough structure. Incorporation of M. hirsuta fraction into chitosan matrix favorably enhanced the mechanical performance and films thickness. The in vivo wound treatment with CMHF for seven days showed a characteristic area of advanced healing, re-epithelization, cell proliferation, and collagen formation. Furthermore, wound closure reached 100% contraction after 10 days of treatment with modulation of interleukins. The incorporation of M. hirsuta fraction into chitosan films was advantageous and showed great potential for stimulating wound repair and regeneration.

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Fabrication of asymmetric nanostarch reinforced Chitosan/PVP membrane and its evaluation as an antibacterial patch for in vivo wound healing application

Cited by 59 publications

References 34 publications

Films of chitosan and natural modified hydroxyapatite as effective UV-protecting, biocompatible and antibacterial wound dressings

Films of chitosan and natural modified hydroxyapatite as effective UV-protecting, biocompatible and antibacterial wound dressings

Silver triethanolamine-loaded PVB/CO films for a potential liquid bandage application

Chitosan Film Containing Mansoa hirsuta Fraction for Wound Healing

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