Fabrication of amphotericin B-loaded electrospun core–shell nanofibers as a novel dressing for superficial mycoses and cutaneous leishmaniasis

Asgari, Qasem; Alishahi, M; Davani, Farideh; Caravan, Dorsa; Khorram, Mohammad; Enjavi, Yasaman; Barzegar, Sajjad; Esfandiari, Farideh; Zomorodian, Kamiar

doi:10.1016/j.ijpharm.2021.120911

Cited by 13 publications

(7 citation statements)

References 54 publications

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“…In this regard, the peaks at around 1615 and 1425 cm –1 were attributed to the stretching vibration of COO – and the carbonyl group of NHCOO – , respectively, in the structure of Fe 3 O 4 @SiO 2 -L NPs after CO 2 absorption. Further, a peak at around 2318 cm –1 shows the chemical reaction of amino acid salt and CO 2 and formation of carbamate on the structure of functionalized NPs. − …”

Section: Resultsmentioning

confidence: 99%

Highly Selective Physical/Chemical CO₂ Separation by Functionalized Fe₃O₄ Nanoparticles in Hollow Fiber Membrane Contactors: Experimental and Modeling Approaches

et al. 2022

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Herein, different water-based modified magnetite nanodispersions of Fe3O4-proline (Fe3O4-P), Fe3O4-lysine (Fe3O4-L), Fe3O4@SiO2-proline (Fe3O4@SiO2-P), and Fe3O4@SiO2-lysine (Fe3O4@SiO2-L) were prepared to improve the stability and absorption capacity of bare Fe3O4 nanodispersion for selective physical/chemical carbon dioxide (CO2) separation in a polypropylene hollow fiber membrane contactor (PP HFMC). The liquid was passed through the tube side and CO2 gas was passed through the shell side concurrently. Subsequently, the impacts of varying nanoparticle (NP) loadings, gas/liquid flow rates (Q l/Q g), and NP stability on CO2 separation were elucidated. Considering the achieved results, all modified NPs revealed higher selective CO2 separation performances compared to bare Fe3O4 NPs because of functionalization with chemical reactants of CO2. Also, for the first time, to evaluate the influence of the CO2 inlet concentration and wetting parameter, a new and simple model was proposed in which the behavior of functional NPs was considered. Ultimately, the CO2 removal enhancements of 27.5, 57.14, 64.28, 72.8, and 96.42% were achieved for Fe3O4, Fe3O4-P, Fe3O4-L, Fe3O4@SiO2-P, and Fe3O4@SiO2-L at optimal NP loadings and in the best operational conditions (i.e., Q l = 10 mL·min–1 and Q g = 100 mL·min–1).

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Section: Resultsmentioning

confidence: 99%

Highly Selective Physical/Chemical CO₂ Separation by Functionalized Fe₃O₄ Nanoparticles in Hollow Fiber Membrane Contactors: Experimental and Modeling Approaches

et al. 2022

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“…Even two different synthetic or natural polymers can be blended together for the preparation of nanofibers. Amphotericin B-loaded coaxial nanofibers were fabricated using PVA, chitosan, poly(ethylene oxide), and gelatin to make a new dressing for cutaneous leishmaniasis and superficial mycoses . As a result, polymers are crucial in the development of nanofibers that serve the intended applications.…”

Section: Fabrication Of Nanofibersmentioning

confidence: 99%

Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

Tomar,

Pandit,

Priya

et al. 2023

ACS Omega

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Nanotechnology has yielded nanostructure-based drug delivery approaches, among which nanofibers have been explored and researched for the potential topical delivery of therapeutics. Nanofibers are filaments or thread-like structures in the nanometer size range that are fabricated using various polymers, such as natural or synthetic polymers or their combination. The size or diameter of the nanofibers depends upon the polymers, the techniques of preparation, and the design specification. The four major processing techniques, phase separation, self-assembly, template synthesis, and electrospinning, are most commonly used for the fabrication of nanofibers. Nanofibers have a unique structure that needs a multimethod approach to study their morphology and characterization parameters. They are gaining attention as drug delivery carriers, and the substantially vast surface area of the skin makes it a potentially promising strategy for topical drug products for various skin disorders such as psoriasis, skin cancers, skin wounds, bacterial and fungal infections, etc. However, the large-scale production of nanofibers with desired properties remains challenging, as the widely used electrospinning processes have certain limitations, such as poor yield, use of high voltage, and difficulty in achieving in situ nanofiber deposition on various substrates. This review highlights the insights into fabrication strategies, applications, recent clinical trials, and patents of nanofibers for different skin disorders in detail. Additionally, it discusses case studies of its effective utilization in the treatment of various skin disorders for a better understanding for readers.

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“…Semnani et al, 49 investigated the possibility of using fluconazole locally and as a carrier with the help of polymeric nano and micro fibers in the treatment of infections caused by Candida albicans. Asgari et al, 51 produced AmB-loaded core-shell nanofibers using PVA, chitosan, AmB as cores and PEO and gelatin as shell-forming components to minimize AmB side effects. After the solutions were prepared, they were transferred to syringes and placed in pumps.…”

Section: Liposomesmentioning

confidence: 99%

Innovative Drug Delivery Systems for Infectious Diseases of the Skin

Esentürk-Güzel

Kara²

2022

Univ J Pharm Res

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Introduction: Skin is the organ of the body that is exposed mostly to the microorganisms. Bacteria, fungi, and viruses are usually responsible for the infection of the skin. Due to lack of penetration through the stratum corneum of conventional systems used in infectious diseases of the skin leads to a decrease in bioavailability. For this reason, nanoscale drug delivery systems that could be used in infectious diseases of the skin are currently being investigated. Areas covered: In this review, innovative studies conducted over the years are presented. New topical formulations such as nanoparticles, microemulsions, liposomes, nanofibers and micelles etc are widely used and topic of research for many researchers. Conclusion:Studies have shown that the smaller size and control of these delivery systems provide more effective treatment by increasing drug penetration into the skin. It has been found that drug delivery systems provide a better antimicrobial effect, especially in resistant infections caused by MRSA.

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Fabrication of amphotericin B-loaded electrospun core–shell nanofibers as a novel dressing for superficial mycoses and cutaneous leishmaniasis

Cited by 13 publications

References 54 publications

Highly Selective Physical/Chemical CO₂ Separation by Functionalized Fe₃O₄ Nanoparticles in Hollow Fiber Membrane Contactors: Experimental and Modeling Approaches

Highly Selective Physical/Chemical CO₂ Separation by Functionalized Fe₃O₄ Nanoparticles in Hollow Fiber Membrane Contactors: Experimental and Modeling Approaches

Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

Innovative Drug Delivery Systems for Infectious Diseases of the Skin

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Fabrication of amphotericin B-loaded electrospun core–shell nanofibers as a novel dressing for superficial mycoses and cutaneous leishmaniasis

Cited by 13 publications

References 54 publications

Highly Selective Physical/Chemical CO2 Separation by Functionalized Fe3O4 Nanoparticles in Hollow Fiber Membrane Contactors: Experimental and Modeling Approaches

Highly Selective Physical/Chemical CO2 Separation by Functionalized Fe3O4 Nanoparticles in Hollow Fiber Membrane Contactors: Experimental and Modeling Approaches

Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

Innovative Drug Delivery Systems for Infectious Diseases of the Skin

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Product

Resources

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Highly Selective Physical/Chemical CO₂ Separation by Functionalized Fe₃O₄ Nanoparticles in Hollow Fiber Membrane Contactors: Experimental and Modeling Approaches

Highly Selective Physical/Chemical CO₂ Separation by Functionalized Fe₃O₄ Nanoparticles in Hollow Fiber Membrane Contactors: Experimental and Modeling Approaches