Fabrication of All Glass Bifurcation Microfluidic Chip for Blood Plasma Separation

Jang, Hyungjun; Haq, Muhammad Refatul; Ju, Jonghyun; Kim, Youngkyu; Kim, Seok-Min; Lim, Jiseok

doi:10.3390/mi8030067

Cited by 15 publications

(15 citation statements)

References 40 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pinto et al [ 4 ] used equipment for printed circuit board (PCB) industries instead of a cleanroom facility to create well-defined SU-8 microstructures with a minimum resolution of 10 μm and an aspect ratio of 20. Jang et al [ 5 ] reported a method to fabricate glass microfluidic device for blood plasma separation, in which they used multiple replication processes to create glass microfluidic chips. Compared to other methods used for fabricating glass microfluidic chips, this method is relatively low-cost.…”

Section: Introductionmentioning

confidence: 99%

Micromachining Microchannels on Cyclic Olefin Copolymer (COC) Substrates with the Taguchi Method

et al. 2017

View full text Add to dashboard Cite

Micromilling is a straightforward approach to the manufacture of polymer microfluidic devices for applications in chemistry and biology. This fabrication process reduces costs, provides a relatively simple user interface, and enables the fabrication of complex structures, which makes it ideal for the development of prototypes. In this study, we investigated the influence of micromilling parameters on the surface roughness of a cyclic olefin copolymer (COC) substrate. We then employed factor analysis to determine the optimal cutting conditions. The parameters used in all experiments were the spindle speed, the feed rate, and the depth of cut. Roughness was measured using a stylus profilometer. The lowest roughness was 0.173 μm at a spindle speed of 20,000 rpm, feed rate of 300 mm/min, and cut depth of 20 μm. Factor analysis revealed that the feed rate has the greatest impact on surface quality, whereas the depth of cut has the least impact.

show abstract

Section: Introductionmentioning

confidence: 99%

Micromachining Microchannels on Cyclic Olefin Copolymer (COC) Substrates with the Taguchi Method

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Examples of micro/nano glass molding using GC molds are summarized in Table S5 of the Supplementary Material [ 23 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 116 , 117 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 ]. There are approaches available to fabricate GC molds.…”

Section: Mold Materials For Precision Glass Moldingmentioning

confidence: 99%

A Comprehensive Review of Micro/Nano Precision Glass Molding Molds and Their Fabrication Methods

et al. 2021

Self Cite

View full text Add to dashboard Cite

Micro/nano-precision glass molding (MNPGM) is an efficient approach for manufacturing micro/nanostructured glass components with intricate geometry and a high-quality optical finish. In MNPGM, the mold, which directly imprints the desired pattern on the glass substrate, is a key component. To date, a wide variety of mold inserts have been utilized in MNPGM. The aim of this article is to review the latest advances in molds for MNPGM and their fabrication methods. Surface finishing is specifically addressed because molded glass is usually intended for optical applications in which the surface roughness should be lower than the wavelength of incident light to avoid scattering loss. The use of molds for a wide range of molding temperatures is also discussed in detail. Finally, a series of tables summarizing the mold fabrication methods, mold patterns and their dimensions, anti-adhesion coatings, molding conditions, molding methods, surface roughness values, glass substrates and their glass transition temperatures, and associated applications are presented. This review is intended as a roadmap for those interested in the glass molding field.

show abstract

“…However, these methods are expensive when large-area VC stamps or multiple VC stamps are required. Given that the VC material is obtained by the carbonization of a high carbon yield polymer, a fabrication method for VC micro stamps was proposed based on the carbonization of a micropatterned high carbon yield polymer [16,17].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Cross-Sinusoidal Anti-Reflection Nanostructure on a Glass Substrate Using Imperfect Glass Imprinting with a Nano-Pin Array Vitreous Carbon Stamp

et al. 2020

Self Cite

View full text Add to dashboard Cite

Although polymer nanoimprinting on glass substrates has been widely employed for the fabrication of functional anti-reflective (AR) nanostructures, several drawbacks exist with respect to durability and delamination. The direct patterning of glass material is a potential solution for outdoor applications that require AR functional nanostructured glass plates. In this study, a glass imprinting technique was employed for the fabrication of an AR nanostructure on a soda-lime glass substrate using a vitreous carbon (VC) stamp. The VC stamp, which had a high aspect ratio nanopost array with a pitch of 325 nm, diameter of 110 nm, and height of ~220 nm, was fabricated by the carbonization of a replicated Furan precursor from an Si master. During the glass imprinting process using the nanopost array VC stamp, the softened glass material gradually protruded into the spaces between the nanopins owing to viscoelastic behavior, and one can achieve a cross-sinusoidal surface relief under specific imprinting condition, which can be used as an AR nanostructure with a gradually increasing refractive index. The effects of the processing temperature on the surface profile of the glass imprinted parts and the measured transmission spectra were analyzed, and a glass imprinting temperature of 700 °C and pressure of 1 MPa were found to be the optimum condition. The height of the fabricated cross-sinusoidal nanostructure was 80 nm, and the light transmission was increased by ~2% over the entire visible-light range. Furthermore, the measured transmission spectrum observed to be in good agreement with the simulation results.

show abstract

Fabrication of All Glass Bifurcation Microfluidic Chip for Blood Plasma Separation

Cited by 15 publications

References 40 publications

Micromachining Microchannels on Cyclic Olefin Copolymer (COC) Substrates with the Taguchi Method

Micromachining Microchannels on Cyclic Olefin Copolymer (COC) Substrates with the Taguchi Method

A Comprehensive Review of Micro/Nano Precision Glass Molding Molds and Their Fabrication Methods

Fabrication of Cross-Sinusoidal Anti-Reflection Nanostructure on a Glass Substrate Using Imperfect Glass Imprinting with a Nano-Pin Array Vitreous Carbon Stamp

Contact Info

Product

Resources

About